The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study

The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study

Litong Yao,1,2,* Xinyu Wang,2,* Yifan Zhong,3,* Yan Wang,4,* Jingyang Wu,3 Jin Geng,3 Yun Zhou,3 Jun Chen,3 Peng Guan,5 Yingying Xu,1 Lei Chen,3 Lei Liu,3 Yuedong Hu3 1Department of Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic o...

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Autores principales: Yao L, Wang X, Zhong Y, Wang Y, Wu J, Geng J, Zhou Y, Chen J, Guan P, Xu Y, Chen L, Liu L, Hu Y
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
diabetic retinopathy
triglyceride-glucose index
type 2 diabetes
hospital based nested case-control study
Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/b002aad27f8e4b8186f689f68b60222b
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spelling oai:doaj.org-article:b002aad27f8e4b8186f689f68b60222b2021-12-02T14:37:16ZThe Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study1178-7007https://doaj.org/article/b002aad27f8e4b8186f689f68b60222b2021-04-01T00:00:00Zhttps://www.dovepress.com/the-triglyceridendashglucose-index-is-associated-with-diabetic-retinop-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Litong Yao,1,2,* Xinyu Wang,2,* Yifan Zhong,3,* Yan Wang,4,* Jingyang Wu,3 Jin Geng,3 Yun Zhou,3 Jun Chen,3 Peng Guan,5 Yingying Xu,1 Lei Chen,3 Lei Liu,3 Yuedong Hu3 1Department of Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2China Medical University, Shenyang, 110001, People’s Republic of China; 3Department of Ophthalmology, First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 4Department of Radiology, General Hospital of Liaohe Oil Field, Panjin, 124010, People’s Republic of China; 5Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Liu; Yuedong HuDepartment of Ophthalmology, First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, Liaoning Province, People’s Republic of ChinaTel/Fax +86-24-8328-2277Email liuleijiao@163.com; laser2005sy@126.comBackground: This study aimed to investigate the association between the triglyceride–glucose (TyG) index and diabetic retinopathy (DR) in Chinese patients with type 2 diabetes.Methods: In this nested case–control study, all diabetic participants were registered hospitalizations during 2012– 2018, including 596 with DR as cases and three matching controls per case. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. The TyG index was calculated: Ln (fasting blood glucose [mg/dL] × fasting triglycerides [mg/dL] ÷ 2). Multivariate logistic regression, a receiver-operating characteristic (ROC) curve, linear regression models, and mediation analysis were used to explore associations.Results: The TyG index was lower in DR and decreased as its severity advanced among 2,112 subjects (P=0.005). After confounders (sex, duration of diabetes, use of antidiabetic agents, heart rate, systolic blood pressure, pulse pressure, height, weight, body-mass index, and glycated hemoglobin) had been accounted for, there were significant associations between the TyG index and any-severity DR (OR 0.83, 95% CI 0.73– 0.95; P=0.006), as well as vision-threatening DR (VTDR; OR 0.53, 95% CI 0.36– 0.76; P=0.001). ROC analysis indicated that the TyG index showed significant discriminatory ability in any-severity DR (area under curve [AUC] 0.534, P=0.015) and VTDR (AUC 0.624, P=0.001).Conclusion: The TyG index was associated with the presence and severity of DR. Our findings suggest that the TyG index may become a useful biomarker in evaluating and following the presence of DR and VTDR.Keywords: diabetic retinopathy, triglyceride–glucose index, type 2 diabetes, hospital-based nested case–control studyYao LWang XZhong YWang YWu JGeng JZhou YChen JGuan PXu YChen LLiu LHu YDove Medical Pressarticlediabetic retinopathytriglyceride-glucose indextype 2 diabeteshospital based nested case-control studySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1547-1555 (2021)
institution DOAJ
collection DOAJ
language EN
topic diabetic retinopathy
triglyceride-glucose index
type 2 diabetes
hospital based nested case-control study
Specialties of internal medicine
RC581-951
spellingShingle diabetic retinopathy
triglyceride-glucose index
type 2 diabetes
hospital based nested case-control study
Specialties of internal medicine
RC581-951
Yao L
Wang X
Zhong Y
Wang Y
Wu J
Geng J
Zhou Y
Chen J
Guan P
Xu Y
Chen L
Liu L
Hu Y
The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study
description Litong Yao,1,2,* Xinyu Wang,2,* Yifan Zhong,3,* Yan Wang,4,* Jingyang Wu,3 Jin Geng,3 Yun Zhou,3 Jun Chen,3 Peng Guan,5 Yingying Xu,1 Lei Chen,3 Lei Liu,3 Yuedong Hu3 1Department of Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2China Medical University, Shenyang, 110001, People’s Republic of China; 3Department of Ophthalmology, First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 4Department of Radiology, General Hospital of Liaohe Oil Field, Panjin, 124010, People’s Republic of China; 5Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Liu; Yuedong HuDepartment of Ophthalmology, First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, Liaoning Province, People’s Republic of ChinaTel/Fax +86-24-8328-2277Email liuleijiao@163.com; laser2005sy@126.comBackground: This study aimed to investigate the association between the triglyceride–glucose (TyG) index and diabetic retinopathy (DR) in Chinese patients with type 2 diabetes.Methods: In this nested case–control study, all diabetic participants were registered hospitalizations during 2012– 2018, including 596 with DR as cases and three matching controls per case. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. The TyG index was calculated: Ln (fasting blood glucose [mg/dL] × fasting triglycerides [mg/dL] ÷ 2). Multivariate logistic regression, a receiver-operating characteristic (ROC) curve, linear regression models, and mediation analysis were used to explore associations.Results: The TyG index was lower in DR and decreased as its severity advanced among 2,112 subjects (P=0.005). After confounders (sex, duration of diabetes, use of antidiabetic agents, heart rate, systolic blood pressure, pulse pressure, height, weight, body-mass index, and glycated hemoglobin) had been accounted for, there were significant associations between the TyG index and any-severity DR (OR 0.83, 95% CI 0.73– 0.95; P=0.006), as well as vision-threatening DR (VTDR; OR 0.53, 95% CI 0.36– 0.76; P=0.001). ROC analysis indicated that the TyG index showed significant discriminatory ability in any-severity DR (area under curve [AUC] 0.534, P=0.015) and VTDR (AUC 0.624, P=0.001).Conclusion: The TyG index was associated with the presence and severity of DR. Our findings suggest that the TyG index may become a useful biomarker in evaluating and following the presence of DR and VTDR.Keywords: diabetic retinopathy, triglyceride–glucose index, type 2 diabetes, hospital-based nested case–control study
format article
author Yao L
Wang X
Zhong Y
Wang Y
Wu J
Geng J
Zhou Y
Chen J
Guan P
Xu Y
Chen L
Liu L
Hu Y
author_facet Yao L
Wang X
Zhong Y
Wang Y
Wu J
Geng J
Zhou Y
Chen J
Guan P
Xu Y
Chen L
Liu L
Hu Y
author_sort Yao L
title The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study
title_short The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study
title_full The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study
title_fullStr The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study
title_full_unstemmed The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study
title_sort triglyceride–glucose index is associated with diabetic retinopathy in chinese patients with type 2 diabetes: a hospital-based, nested, case–control study
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/b002aad27f8e4b8186f689f68b60222b
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