Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans

The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.

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Autores principales:	Laura K. Case, Jaquette Liljencrantz, Nicholas Madian, Aaron Necaise, Justin Tubbs, Micaela McCall, Megan L. Bradson, Marcin Szczot, Mark H. Pitcher, Nima Ghitani, Eleni Frangos, Jonathan Cole, Diana Bharucha-Goebel, Dimah Saade, Tracy Ogata, Sandra Donkervoort, A. Reghan Foley, Carsten G. Bönnemann, Håkan Olausson, M. Catherine Bushnell, Alexander T. Chesler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b005162b0b26483ea9700b4ecfd44b19
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spelling	oai:doaj.org-article:b005162b0b26483ea9700b4ecfd44b192021-12-02T10:48:27ZInnocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans10.1038/s41467-021-20939-52041-1723https://doaj.org/article/b005162b0b26483ea9700b4ecfd44b192021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20939-5https://doaj.org/toc/2041-1723The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.Laura K. CaseJaquette LiljencrantzNicholas MadianAaron NecaiseJustin TubbsMicaela McCallMegan L. BradsonMarcin SzczotMark H. PitcherNima GhitaniEleni FrangosJonathan ColeDiana Bharucha-GoebelDimah SaadeTracy OgataSandra DonkervoortA. Reghan FoleyCarsten G. BönnemannHåkan OlaussonM. Catherine BushnellAlexander T. CheslerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura K. Case Jaquette Liljencrantz Nicholas Madian Aaron Necaise Justin Tubbs Micaela McCall Megan L. Bradson Marcin Szczot Mark H. Pitcher Nima Ghitani Eleni Frangos Jonathan Cole Diana Bharucha-Goebel Dimah Saade Tracy Ogata Sandra Donkervoort A. Reghan Foley Carsten G. Bönnemann Håkan Olausson M. Catherine Bushnell Alexander T. Chesler Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
description	The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.
format	article
author	Laura K. Case Jaquette Liljencrantz Nicholas Madian Aaron Necaise Justin Tubbs Micaela McCall Megan L. Bradson Marcin Szczot Mark H. Pitcher Nima Ghitani Eleni Frangos Jonathan Cole Diana Bharucha-Goebel Dimah Saade Tracy Ogata Sandra Donkervoort A. Reghan Foley Carsten G. Bönnemann Håkan Olausson M. Catherine Bushnell Alexander T. Chesler
author_facet	Laura K. Case Jaquette Liljencrantz Nicholas Madian Aaron Necaise Justin Tubbs Micaela McCall Megan L. Bradson Marcin Szczot Mark H. Pitcher Nima Ghitani Eleni Frangos Jonathan Cole Diana Bharucha-Goebel Dimah Saade Tracy Ogata Sandra Donkervoort A. Reghan Foley Carsten G. Bönnemann Håkan Olausson M. Catherine Bushnell Alexander T. Chesler
author_sort	Laura K. Case
title	Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
title_short	Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
title_full	Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
title_fullStr	Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
title_full_unstemmed	Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
title_sort	innocuous pressure sensation requires a-type afferents but not functional ριεζο2 channels in humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b005162b0b26483ea9700b4ecfd44b19
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Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans

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