Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles

Extracellular vesicles (EV) are known to be released from the primary cilium, but the role ciliary proteins play in EV biogenesis remains unexplored. Here, the authors demonstrate increased secretion of small EVs with altered cargo composition from cells with known ciliarelated mutations. Wnt relate...

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Autores principales:	Ann-Kathrin Volz, Alina Frei, Viola Kretschmer, António M. de Jesus Domingues, Rene F. Ketting, Marius Ueffing, Karsten Boldt, Eva-Maria Krämer-Albers, Helen L. May-Simera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b005eb92f5e343fd9d632f94442efafa
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spelling	oai:doaj.org-article:b005eb92f5e343fd9d632f94442efafa2021-12-02T17:18:32ZBardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles10.1038/s41467-021-25929-12041-1723https://doaj.org/article/b005eb92f5e343fd9d632f94442efafa2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25929-1https://doaj.org/toc/2041-1723Extracellular vesicles (EV) are known to be released from the primary cilium, but the role ciliary proteins play in EV biogenesis remains unexplored. Here, the authors demonstrate increased secretion of small EVs with altered cargo composition from cells with known ciliarelated mutations. Wnt related molecules made up a majority of altered cargoAnn-Kathrin VolzAlina FreiViola KretschmerAntónio M. de Jesus DominguesRene F. KettingMarius UeffingKarsten BoldtEva-Maria Krämer-AlbersHelen L. May-SimeraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ann-Kathrin Volz Alina Frei Viola Kretschmer António M. de Jesus Domingues Rene F. Ketting Marius Ueffing Karsten Boldt Eva-Maria Krämer-Albers Helen L. May-Simera Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
description	Extracellular vesicles (EV) are known to be released from the primary cilium, but the role ciliary proteins play in EV biogenesis remains unexplored. Here, the authors demonstrate increased secretion of small EVs with altered cargo composition from cells with known ciliarelated mutations. Wnt related molecules made up a majority of altered cargo
format	article
author	Ann-Kathrin Volz Alina Frei Viola Kretschmer António M. de Jesus Domingues Rene F. Ketting Marius Ueffing Karsten Boldt Eva-Maria Krämer-Albers Helen L. May-Simera
author_facet	Ann-Kathrin Volz Alina Frei Viola Kretschmer António M. de Jesus Domingues Rene F. Ketting Marius Ueffing Karsten Boldt Eva-Maria Krämer-Albers Helen L. May-Simera
author_sort	Ann-Kathrin Volz
title	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
title_short	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
title_full	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
title_fullStr	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
title_full_unstemmed	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
title_sort	bardet-biedl syndrome proteins modulate the release of bioactive extracellular vesicles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b005eb92f5e343fd9d632f94442efafa
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Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles

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