The association between telomere length and ischemic stroke risk and phenotype

Abstract The chronological age of a person is a key determinant of etiology and prognosis in the setting of ischemic stroke. Telomere length, an indicator of biological aging, progressively shortens with every cell cycle. Herein, we determined telomere length from peripheral blood leukocytes by Sout...

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Autores principales:	Ezgi Yetim, Mehmet Akif Topcuoglu, Nuket Yurur Kutlay, Ajlan Tukun, Kader K. Oguz, Ethem Murat Arsava
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b0086a489b114a77aed8fd4f5b83afa4
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spelling	oai:doaj.org-article:b0086a489b114a77aed8fd4f5b83afa42021-12-02T15:49:28ZThe association between telomere length and ischemic stroke risk and phenotype10.1038/s41598-021-90435-92045-2322https://doaj.org/article/b0086a489b114a77aed8fd4f5b83afa42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90435-9https://doaj.org/toc/2045-2322Abstract The chronological age of a person is a key determinant of etiology and prognosis in the setting of ischemic stroke. Telomere length, an indicator of biological aging, progressively shortens with every cell cycle. Herein, we determined telomere length from peripheral blood leukocytes by Southern blot analyses in a prospective cohort of ischemic stroke patients (n = 163) and equal number of non-stroke controls and evaluated its association with various ischemic stroke features including etiology, severity, and outcome. A shorter telomere length (i.e. lowest quartile; ≤ 5.5 kb) was significantly associated with ischemic stroke (OR 2.95, 95% CI 1.70–5.13). This significant relationship persisted for all stroke etiologies, except for other rare causes of stroke. No significant association was present between admission lesion volume and telomere length; however, patients with shorter telomeres had higher admission National Institutes of Health Stroke Scale scores when adjusted for chronological age, risk factors, etiology, and infarct volume (p = 0.046). On the other hand, chronological age, but not telomere length, was associated with unfavorable outcome (modified Rankin scale > 2) and mortality at 90 days follow-up. The association between shorter telomere length and more severe clinical phenotype at the time of admission, might reflect reduced resilience of cerebral tissue to ischemia as part of biological aging.Ezgi YetimMehmet Akif TopcuogluNuket Yurur KutlayAjlan TukunKader K. OguzEthem Murat ArsavaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ezgi Yetim Mehmet Akif Topcuoglu Nuket Yurur Kutlay Ajlan Tukun Kader K. Oguz Ethem Murat Arsava The association between telomere length and ischemic stroke risk and phenotype
description	Abstract The chronological age of a person is a key determinant of etiology and prognosis in the setting of ischemic stroke. Telomere length, an indicator of biological aging, progressively shortens with every cell cycle. Herein, we determined telomere length from peripheral blood leukocytes by Southern blot analyses in a prospective cohort of ischemic stroke patients (n = 163) and equal number of non-stroke controls and evaluated its association with various ischemic stroke features including etiology, severity, and outcome. A shorter telomere length (i.e. lowest quartile; ≤ 5.5 kb) was significantly associated with ischemic stroke (OR 2.95, 95% CI 1.70–5.13). This significant relationship persisted for all stroke etiologies, except for other rare causes of stroke. No significant association was present between admission lesion volume and telomere length; however, patients with shorter telomeres had higher admission National Institutes of Health Stroke Scale scores when adjusted for chronological age, risk factors, etiology, and infarct volume (p = 0.046). On the other hand, chronological age, but not telomere length, was associated with unfavorable outcome (modified Rankin scale > 2) and mortality at 90 days follow-up. The association between shorter telomere length and more severe clinical phenotype at the time of admission, might reflect reduced resilience of cerebral tissue to ischemia as part of biological aging.
format	article
author	Ezgi Yetim Mehmet Akif Topcuoglu Nuket Yurur Kutlay Ajlan Tukun Kader K. Oguz Ethem Murat Arsava
author_facet	Ezgi Yetim Mehmet Akif Topcuoglu Nuket Yurur Kutlay Ajlan Tukun Kader K. Oguz Ethem Murat Arsava
author_sort	Ezgi Yetim
title	The association between telomere length and ischemic stroke risk and phenotype
title_short	The association between telomere length and ischemic stroke risk and phenotype
title_full	The association between telomere length and ischemic stroke risk and phenotype
title_fullStr	The association between telomere length and ischemic stroke risk and phenotype
title_full_unstemmed	The association between telomere length and ischemic stroke risk and phenotype
title_sort	association between telomere length and ischemic stroke risk and phenotype
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b0086a489b114a77aed8fd4f5b83afa4
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The association between telomere length and ischemic stroke risk and phenotype

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