Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population

Background: Recent data have shown an inverse association between serum 25-hydroxyvitamin D concentration and incidence of several cancers, including cutaneous malignant melanoma (CMM). In addition, lower serum 25-hydroxyvitamin D levels have been associated with thicker or higher stage melanomas a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Angeliki Befon, Alexander C. Katoulis, Sofia Georgala, Andreas Katsampas, Vasiliki Chardalia, Aggeliki Melpidou, Vasiliki Tzanetakou, Vasiliki Chasapi, Dorothea Polydorou, Clio Desinioti, Micaela Plaka, Dimitris Rigopoulos, Alexandros J. Stratigos
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2019
Materias:	malignant melanoma vitamin D Breslow thickness ulceration risk factors prognosis Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/b00975b27f6a4666ac688eefc7aac231
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b00975b27f6a4666ac688eefc7aac231
record_format	dspace
spelling	oai:doaj.org-article:b00975b27f6a4666ac688eefc7aac2312021-11-17T08:29:00ZSerum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population10.5826/dpc.1001a102160-9381https://doaj.org/article/b00975b27f6a4666ac688eefc7aac2312019-12-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1025https://doaj.org/toc/2160-9381 Background: Recent data have shown an inverse association between serum 25-hydroxyvitamin D concentration and incidence of several cancers, including cutaneous malignant melanoma (CMM). In addition, lower serum 25-hydroxyvitamin D levels have been associated with thicker or higher stage melanomas and worse survival in observational studies. Materials and Methods: Ninety-nine patients diagnosed with primary CMM and 97 matched healthy controls entered the study. Demographic characteristics, risk factors for CMM, and clinical and histological characteristics were recorded for patients with primary CMM. Total serum 25-hydroxyvitamin D levels of melanoma patients measured by fully automated chemiluminescent vitamin D total immunoassay (Elecsys vitamin D total, Roche) at the time of diagnosis were compared with those of healthy controls. In addition, we tested the association of serum total 25-hydroxyvitamin D levels at melanoma diagnosis with known risk and prognostic factors for CMM. Results: Of the melanoma patients, 49 (49.49%) had deficient serum total 25-hydroxyvitamin D levels (<20 ng/mL), 23 (23.23%) had insufficient levels (21-29 ng/mL), and 27 (27.27%) had adequate levels (>30 ng/mL). The median serum total 25-hydroxyvitamin D levels were significantly lower in melanoma patients (20.62 ng/mL) compared with healthy controls (24.71 ng/mL), but statistical significance was not reached (chi-square test, P = 0.051) No statistically significant association was found between serum total 25-hydroxyvitamin D levels and demographic characteristics; risk factors for CMM; prognostic factors, such as Breslow thickness and ulceration; as well as clinical characteristics, such as melanoma stage, clinical type, and location. Conclusions: Lower serum 25-hydroxyvitamin D levels were found in our Greek cohort of melanoma patients compared with healthy controls, without reaching, however, statistical significance; these levels were not statistically associated with established risk and prognostic factors for CMM. Angeliki BefonAlexander C. KatoulisSofia GeorgalaAndreas KatsampasVasiliki ChardaliaAggeliki MelpidouVasiliki TzanetakouVasiliki ChasapiDorothea PolydorouClio DesiniotiMicaela PlakaDimitris RigopoulosAlexandros J. StratigosMattioli1885articlemalignant melanomavitamin DBreslow thicknessulcerationrisk factorsprognosisDermatologyRL1-803ENDermatology Practical & Conceptual (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant melanoma vitamin D Breslow thickness ulceration risk factors prognosis Dermatology RL1-803
spellingShingle	malignant melanoma vitamin D Breslow thickness ulceration risk factors prognosis Dermatology RL1-803 Angeliki Befon Alexander C. Katoulis Sofia Georgala Andreas Katsampas Vasiliki Chardalia Aggeliki Melpidou Vasiliki Tzanetakou Vasiliki Chasapi Dorothea Polydorou Clio Desinioti Micaela Plaka Dimitris Rigopoulos Alexandros J. Stratigos Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population
description	Background: Recent data have shown an inverse association between serum 25-hydroxyvitamin D concentration and incidence of several cancers, including cutaneous malignant melanoma (CMM). In addition, lower serum 25-hydroxyvitamin D levels have been associated with thicker or higher stage melanomas and worse survival in observational studies. Materials and Methods: Ninety-nine patients diagnosed with primary CMM and 97 matched healthy controls entered the study. Demographic characteristics, risk factors for CMM, and clinical and histological characteristics were recorded for patients with primary CMM. Total serum 25-hydroxyvitamin D levels of melanoma patients measured by fully automated chemiluminescent vitamin D total immunoassay (Elecsys vitamin D total, Roche) at the time of diagnosis were compared with those of healthy controls. In addition, we tested the association of serum total 25-hydroxyvitamin D levels at melanoma diagnosis with known risk and prognostic factors for CMM. Results: Of the melanoma patients, 49 (49.49%) had deficient serum total 25-hydroxyvitamin D levels (<20 ng/mL), 23 (23.23%) had insufficient levels (21-29 ng/mL), and 27 (27.27%) had adequate levels (>30 ng/mL). The median serum total 25-hydroxyvitamin D levels were significantly lower in melanoma patients (20.62 ng/mL) compared with healthy controls (24.71 ng/mL), but statistical significance was not reached (chi-square test, P = 0.051) No statistically significant association was found between serum total 25-hydroxyvitamin D levels and demographic characteristics; risk factors for CMM; prognostic factors, such as Breslow thickness and ulceration; as well as clinical characteristics, such as melanoma stage, clinical type, and location. Conclusions: Lower serum 25-hydroxyvitamin D levels were found in our Greek cohort of melanoma patients compared with healthy controls, without reaching, however, statistical significance; these levels were not statistically associated with established risk and prognostic factors for CMM.
format	article
author	Angeliki Befon Alexander C. Katoulis Sofia Georgala Andreas Katsampas Vasiliki Chardalia Aggeliki Melpidou Vasiliki Tzanetakou Vasiliki Chasapi Dorothea Polydorou Clio Desinioti Micaela Plaka Dimitris Rigopoulos Alexandros J. Stratigos
author_facet	Angeliki Befon Alexander C. Katoulis Sofia Georgala Andreas Katsampas Vasiliki Chardalia Aggeliki Melpidou Vasiliki Tzanetakou Vasiliki Chasapi Dorothea Polydorou Clio Desinioti Micaela Plaka Dimitris Rigopoulos Alexandros J. Stratigos
author_sort	Angeliki Befon
title	Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population
title_short	Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population
title_full	Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population
title_fullStr	Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population
title_full_unstemmed	Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population
title_sort	serum total 25-hydroxyvitamin d levels in patients with cutaneous malignant melanoma: a case-control study in a low-risk southern european population
publisher	Mattioli1885
publishDate	2019
url	https://doaj.org/article/b00975b27f6a4666ac688eefc7aac231
work_keys_str_mv	AT angelikibefon serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT alexanderckatoulis serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT sofiageorgala serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT andreaskatsampas serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT vasilikichardalia serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT aggelikimelpidou serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT vasilikitzanetakou serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT vasilikichasapi serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT dorotheapolydorou serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT cliodesinioti serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT micaelaplaka serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT dimitrisrigopoulos serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation AT alexandrosjstratigos serumtotal25hydroxyvitamindlevelsinpatientswithcutaneousmalignantmelanomaacasecontrolstudyinalowrisksoutherneuropeanpopulation
_version_	1718425819710226432

Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population

Ejemplares similares