Clinical analysis of 11 cases of nocardiosis

Nocardiosis is a rare, life-threatening, opportunistic, and suppurative infection. Its clinical manifestation lacks specificity, which makes early diagnosis difficult. A retrospective analysis of the clinical records of 11 patients with nocardiosis admitted to our hospital from January 2013 to Novem...

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Autores principales:	Li Yiqing, Tang Ting, Xiao Jie, Wang Jieyu, Li Boqi, Ma Liping, Xie Shuangfeng, Nie Danian
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	nocardia infections immunosuppressive agents diagnosis therapeutics Medicine R
Acceso en línea:	https://doaj.org/article/b00f1a9676ae4287ade3485f3e476846
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spelling	oai:doaj.org-article:b00f1a9676ae4287ade3485f3e4768462021-12-05T14:10:53ZClinical analysis of 11 cases of nocardiosis2391-546310.1515/med-2020-0196https://doaj.org/article/b00f1a9676ae4287ade3485f3e4768462021-04-01T00:00:00Zhttps://doi.org/10.1515/med-2020-0196https://doaj.org/toc/2391-5463Nocardiosis is a rare, life-threatening, opportunistic, and suppurative infection. Its clinical manifestation lacks specificity, which makes early diagnosis difficult. A retrospective analysis of the clinical records of 11 patients with nocardiosis admitted to our hospital from January 2013 to November 2018 was conducted. All patients had at least one underlying disorder, such as an autoimmune disease (6/11), a blood malignancy (2/11), avascular necrosis of the femoral head (1/11), bronchiectasis (1/11), or pneumonia (1/11). The first-line treatment was trimethoprim–sulfamethoxazole (TMP–SMX); one or two additional antibiotics were given according to the drug-sensitive test. The median time from onset to treatment was 3 weeks (ranging from 1 to 9 weeks). The median duration of treatment after diagnosis was 20.5 weeks (ranging from 7 to 47 weeks). Eight patients were discharged and survived, and three patients died. This indicates that early use of TMP–SMX combined with sensitive antibiotics could improve the condition of patients and improve the cure rate (8/11). Clinically, it is necessary to consider the possibility of nocardiosis in patients with long-term use of immunosuppressants and poor response to treatment of common bacterial infections. Early diagnosis, timely treatment, and combination drug therapy are keys to improving the outcomes of patients with nocardiosis.Li YiqingTang TingXiao JieWang JieyuLi BoqiMa LipingXie ShuangfengNie DanianDe Gruyterarticlenocardia infectionsimmunosuppressive agentsdiagnosistherapeuticsMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 610-617 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nocardia infections immunosuppressive agents diagnosis therapeutics Medicine R
spellingShingle	nocardia infections immunosuppressive agents diagnosis therapeutics Medicine R Li Yiqing Tang Ting Xiao Jie Wang Jieyu Li Boqi Ma Liping Xie Shuangfeng Nie Danian Clinical analysis of 11 cases of nocardiosis
description	Nocardiosis is a rare, life-threatening, opportunistic, and suppurative infection. Its clinical manifestation lacks specificity, which makes early diagnosis difficult. A retrospective analysis of the clinical records of 11 patients with nocardiosis admitted to our hospital from January 2013 to November 2018 was conducted. All patients had at least one underlying disorder, such as an autoimmune disease (6/11), a blood malignancy (2/11), avascular necrosis of the femoral head (1/11), bronchiectasis (1/11), or pneumonia (1/11). The first-line treatment was trimethoprim–sulfamethoxazole (TMP–SMX); one or two additional antibiotics were given according to the drug-sensitive test. The median time from onset to treatment was 3 weeks (ranging from 1 to 9 weeks). The median duration of treatment after diagnosis was 20.5 weeks (ranging from 7 to 47 weeks). Eight patients were discharged and survived, and three patients died. This indicates that early use of TMP–SMX combined with sensitive antibiotics could improve the condition of patients and improve the cure rate (8/11). Clinically, it is necessary to consider the possibility of nocardiosis in patients with long-term use of immunosuppressants and poor response to treatment of common bacterial infections. Early diagnosis, timely treatment, and combination drug therapy are keys to improving the outcomes of patients with nocardiosis.
format	article
author	Li Yiqing Tang Ting Xiao Jie Wang Jieyu Li Boqi Ma Liping Xie Shuangfeng Nie Danian
author_facet	Li Yiqing Tang Ting Xiao Jie Wang Jieyu Li Boqi Ma Liping Xie Shuangfeng Nie Danian
author_sort	Li Yiqing
title	Clinical analysis of 11 cases of nocardiosis
title_short	Clinical analysis of 11 cases of nocardiosis
title_full	Clinical analysis of 11 cases of nocardiosis
title_fullStr	Clinical analysis of 11 cases of nocardiosis
title_full_unstemmed	Clinical analysis of 11 cases of nocardiosis
title_sort	clinical analysis of 11 cases of nocardiosis
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/b00f1a9676ae4287ade3485f3e476846
work_keys_str_mv	AT liyiqing clinicalanalysisof11casesofnocardiosis AT tangting clinicalanalysisof11casesofnocardiosis AT xiaojie clinicalanalysisof11casesofnocardiosis AT wangjieyu clinicalanalysisof11casesofnocardiosis AT liboqi clinicalanalysisof11casesofnocardiosis AT maliping clinicalanalysisof11casesofnocardiosis AT xieshuangfeng clinicalanalysisof11casesofnocardiosis AT niedanian clinicalanalysisof11casesofnocardiosis
_version_	1718371622921961472

Clinical analysis of 11 cases of nocardiosis

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