Neuroimmune endocrine effects of antidepressants

Marco Antonioli, Joanna Rybka, LA CarvalhoPsychoimmunology Translational Laboratory, Health Science Research Centre, Roehampton University, London, UKAbstract: Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its the...

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Autores principales:	Antonioli M, Rybka J, Carvalho LA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b0131f61dba64a15ba84f94212b1c836
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spelling	oai:doaj.org-article:b0131f61dba64a15ba84f94212b1c8362021-12-02T01:46:09ZNeuroimmune endocrine effects of antidepressants1176-63281178-2021https://doaj.org/article/b0131f61dba64a15ba84f94212b1c8362012-02-01T00:00:00Zhttp://www.dovepress.com/neuroimmune-endocrine-effects-of-antidepressants-a9209https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Marco Antonioli, Joanna Rybka, LA CarvalhoPsychoimmunology Translational Laboratory, Health Science Research Centre, Roehampton University, London, UKAbstract: Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its therapeutic effect is still unclear. Many theories have been put forward to account for depression, as well as antidepressant activity, but none of them is exhaustive. Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating corticosteroids along with hyperactivation of the immune system, high levels of proinflammatory cytokines, low levels of melatonin in plasma and urine, and disentrainment of circadian rhythms have been demonstrated. Moreover, antidepressant treatment seems to correct or at least to interfere with these alterations. In this review, we summarize the complex neuroimmune endocrine and chronobiological alterations found in patients with depression and how these systems interact with each other. We also explain how antidepressant therapy can modify these systems, along with some possible mechanisms of action shown in animal and human models.Keywords: antidepressant agents, biological markers, human, cytokines, neuroinflammation, psychoneuroimmunology, endophenotypeAntonioli MRybka JCarvalho LADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 65-83 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Antonioli M Rybka J Carvalho LA Neuroimmune endocrine effects of antidepressants
description	Marco Antonioli, Joanna Rybka, LA CarvalhoPsychoimmunology Translational Laboratory, Health Science Research Centre, Roehampton University, London, UKAbstract: Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its therapeutic effect is still unclear. Many theories have been put forward to account for depression, as well as antidepressant activity, but none of them is exhaustive. Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating corticosteroids along with hyperactivation of the immune system, high levels of proinflammatory cytokines, low levels of melatonin in plasma and urine, and disentrainment of circadian rhythms have been demonstrated. Moreover, antidepressant treatment seems to correct or at least to interfere with these alterations. In this review, we summarize the complex neuroimmune endocrine and chronobiological alterations found in patients with depression and how these systems interact with each other. We also explain how antidepressant therapy can modify these systems, along with some possible mechanisms of action shown in animal and human models.Keywords: antidepressant agents, biological markers, human, cytokines, neuroinflammation, psychoneuroimmunology, endophenotype
format	article
author	Antonioli M Rybka J Carvalho LA
author_facet	Antonioli M Rybka J Carvalho LA
author_sort	Antonioli M
title	Neuroimmune endocrine effects of antidepressants
title_short	Neuroimmune endocrine effects of antidepressants
title_full	Neuroimmune endocrine effects of antidepressants
title_fullStr	Neuroimmune endocrine effects of antidepressants
title_full_unstemmed	Neuroimmune endocrine effects of antidepressants
title_sort	neuroimmune endocrine effects of antidepressants
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/b0131f61dba64a15ba84f94212b1c836
work_keys_str_mv	AT antoniolim neuroimmuneendocrineeffectsofantidepressants AT rybkaj neuroimmuneendocrineeffectsofantidepressants AT carvalhola neuroimmuneendocrineeffectsofantidepressants
_version_	1718402917673730048

Neuroimmune endocrine effects of antidepressants

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