Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

Nootkatone is one of the major active ingredients of <i>Alpiniae oxyphyllae</i>, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression...

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Autores principales:	Chang-Mu Chen, Chen-Yu Lin, Yao-Pang Chung, Chia-Hung Liu, Kuo-Tong Huang, Siao-Syun Guan, Cheng-Tien Wu, Shing-Hwa Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronic kidney disease nootkatone inflammation apoptosis renal fibrosis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b01338e07a1a4d99a261c3b9ea2c464c
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spelling	oai:doaj.org-article:b01338e07a1a4d99a261c3b9ea2c464c2021-11-25T18:35:19ZProtective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model10.3390/nu131139212072-6643https://doaj.org/article/b01338e07a1a4d99a261c3b9ea2c464c2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3921https://doaj.org/toc/2072-6643Nootkatone is one of the major active ingredients of <i>Alpiniae oxyphyllae</i>, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention.Chang-Mu ChenChen-Yu LinYao-Pang ChungChia-Hung LiuKuo-Tong HuangSiao-Syun GuanCheng-Tien WuShing-Hwa LiuMDPI AGarticlechronic kidney diseasenootkatoneinflammationapoptosisrenal fibrosisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3921, p 3921 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease nootkatone inflammation apoptosis renal fibrosis Nutrition. Foods and food supply TX341-641
spellingShingle	chronic kidney disease nootkatone inflammation apoptosis renal fibrosis Nutrition. Foods and food supply TX341-641 Chang-Mu Chen Chen-Yu Lin Yao-Pang Chung Chia-Hung Liu Kuo-Tong Huang Siao-Syun Guan Cheng-Tien Wu Shing-Hwa Liu Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
description	Nootkatone is one of the major active ingredients of <i>Alpiniae oxyphyllae</i>, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention.
format	article
author	Chang-Mu Chen Chen-Yu Lin Yao-Pang Chung Chia-Hung Liu Kuo-Tong Huang Siao-Syun Guan Cheng-Tien Wu Shing-Hwa Liu
author_facet	Chang-Mu Chen Chen-Yu Lin Yao-Pang Chung Chia-Hung Liu Kuo-Tong Huang Siao-Syun Guan Cheng-Tien Wu Shing-Hwa Liu
author_sort	Chang-Mu Chen
title	Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
title_short	Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
title_full	Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
title_fullStr	Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
title_full_unstemmed	Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
title_sort	protective effects of nootkatone on renal inflammation, apoptosis, and fibrosis in a unilateral ureteral obstructive mouse model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b01338e07a1a4d99a261c3b9ea2c464c
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Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

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