Discovery of novel therapeutic properties of drugs from transcriptional responses based on multi-label classification

Abstract Drug repositioning strategies have improved substantially in recent years. At present, two advances are poised to facilitate new strategies. First, the LINCS project can provide rich transcriptome data that reflect the responses of cells upon exposure to various drugs. Second, machine learn...

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Autores principales: Lingwei Xie, Song He, Yuqi Wen, Xiaochen Bo, Zhongnan Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b013c36805df4c8d9dc018e1d5349f5c
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