The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling

Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN’s importance in physiological Wnt signaling.

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Autores principales:	Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0213d02bb5e42d487d2f5912805e034
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spelling	oai:doaj.org-article:b0213d02bb5e42d487d2f5912805e0342021-12-02T19:12:27ZThe E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling10.1038/s41467-021-25634-z2041-1723https://doaj.org/article/b0213d02bb5e42d487d2f5912805e0342021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25634-zhttps://doaj.org/toc/2041-1723Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN’s importance in physiological Wnt signaling.Chen ShenAnmada NayakLeif R. NeitzelAmber A. AdamsMaya Silver-IsenstadtLeah M. SawyerHassina BenchabaneHuilan WangNawat BunnagBin LiDaniel T. WynnFan YangMarta Garcia-ContrerasCharles H. WilliamsSivanesan DakshanamurthyCharles C. HongNagi G. AyadAnthony J. CapobiancoYashi AhmedEthan LeeDavid J. RobbinsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Shen Anmada Nayak Leif R. Neitzel Amber A. Adams Maya Silver-Isenstadt Leah M. Sawyer Hassina Benchabane Huilan Wang Nawat Bunnag Bin Li Daniel T. Wynn Fan Yang Marta Garcia-Contreras Charles H. Williams Sivanesan Dakshanamurthy Charles C. Hong Nagi G. Ayad Anthony J. Capobianco Yashi Ahmed Ethan Lee David J. Robbins The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
description	Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN’s importance in physiological Wnt signaling.
format	article
author	Chen Shen Anmada Nayak Leif R. Neitzel Amber A. Adams Maya Silver-Isenstadt Leah M. Sawyer Hassina Benchabane Huilan Wang Nawat Bunnag Bin Li Daniel T. Wynn Fan Yang Marta Garcia-Contreras Charles H. Williams Sivanesan Dakshanamurthy Charles C. Hong Nagi G. Ayad Anthony J. Capobianco Yashi Ahmed Ethan Lee David J. Robbins
author_facet	Chen Shen Anmada Nayak Leif R. Neitzel Amber A. Adams Maya Silver-Isenstadt Leah M. Sawyer Hassina Benchabane Huilan Wang Nawat Bunnag Bin Li Daniel T. Wynn Fan Yang Marta Garcia-Contreras Charles H. Williams Sivanesan Dakshanamurthy Charles C. Hong Nagi G. Ayad Anthony J. Capobianco Yashi Ahmed Ethan Lee David J. Robbins
author_sort	Chen Shen
title	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
title_short	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
title_full	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
title_fullStr	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
title_full_unstemmed	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
title_sort	e3 ubiquitin ligase component, cereblon, is an evolutionarily conserved regulator of wnt signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b0213d02bb5e42d487d2f5912805e034
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The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling

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