Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site

Abstract In a fishing community Thyborøn-Harboøre on the Danish West coast, a chemical factory polluted air, sea, and ground with > 100 xenobiotic compounds. We investigated cancer incidence in the community. A historical cohort was identified from the Central Population Register and followed for...

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Autores principales:	Elsebeth Lynge, Hans Asger Holmsgaard, Therese L. F. Holmager, Søren Lophaven
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b023ebd9597645179c246451aba99539
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spelling	oai:doaj.org-article:b023ebd9597645179c246451aba995392021-12-02T17:14:30ZCancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site10.1038/s41598-021-92446-y2045-2322https://doaj.org/article/b023ebd9597645179c246451aba995392021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92446-yhttps://doaj.org/toc/2045-2322Abstract In a fishing community Thyborøn-Harboøre on the Danish West coast, a chemical factory polluted air, sea, and ground with > 100 xenobiotic compounds. We investigated cancer incidence in the community. A historical cohort was identified from the Central Population Register and followed for cancer incidence in the Danish Cancer Register including inhabitants from 1968–1970 at height of pollution, and newcomers in 1990–2006 after pollution control. Two fishing communities without pollution, Holmsland and Hanstholm, were referent cohorts. We calculated rate ratios (RR) and 95% confidence intervals (CI). In 1968–1970, 4914 persons lived in Thyborøn-Harboøre, and 9537 persons in Holmsland-Hanstholm. Thyborøn-Harboøre had a statistically significant excess cancer incidence compared with Holmsland-Hanstholm; RR 1.20 (95% CI 1.11–1.29) deriving from kidney and bladder cancer; stomach and lung cancer in men, and colorectal cancer in women. In 1990–2006, 2933 persons came to live in Thyborøn-Harboøre. Their cancer incidence was the same as for newcomers to Holmsland-Hanstholm; RR 1.07 (95% CI 0.88–1.30). Persons in Thyborøn-Harboøre at height of chemical pollution had a cancer risk 20% above persons living in non-polluted fishing communities with a pattern unlikely to be attributable to life style. The study suggested that chemical pollution may have affected cancer risk.Elsebeth LyngeHans Asger HolmsgaardTherese L. F. HolmagerSøren LophavenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elsebeth Lynge Hans Asger Holmsgaard Therese L. F. Holmager Søren Lophaven Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site
description	Abstract In a fishing community Thyborøn-Harboøre on the Danish West coast, a chemical factory polluted air, sea, and ground with > 100 xenobiotic compounds. We investigated cancer incidence in the community. A historical cohort was identified from the Central Population Register and followed for cancer incidence in the Danish Cancer Register including inhabitants from 1968–1970 at height of pollution, and newcomers in 1990–2006 after pollution control. Two fishing communities without pollution, Holmsland and Hanstholm, were referent cohorts. We calculated rate ratios (RR) and 95% confidence intervals (CI). In 1968–1970, 4914 persons lived in Thyborøn-Harboøre, and 9537 persons in Holmsland-Hanstholm. Thyborøn-Harboøre had a statistically significant excess cancer incidence compared with Holmsland-Hanstholm; RR 1.20 (95% CI 1.11–1.29) deriving from kidney and bladder cancer; stomach and lung cancer in men, and colorectal cancer in women. In 1990–2006, 2933 persons came to live in Thyborøn-Harboøre. Their cancer incidence was the same as for newcomers to Holmsland-Hanstholm; RR 1.07 (95% CI 0.88–1.30). Persons in Thyborøn-Harboøre at height of chemical pollution had a cancer risk 20% above persons living in non-polluted fishing communities with a pattern unlikely to be attributable to life style. The study suggested that chemical pollution may have affected cancer risk.
format	article
author	Elsebeth Lynge Hans Asger Holmsgaard Therese L. F. Holmager Søren Lophaven
author_facet	Elsebeth Lynge Hans Asger Holmsgaard Therese L. F. Holmager Søren Lophaven
author_sort	Elsebeth Lynge
title	Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site
title_short	Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site
title_full	Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site
title_fullStr	Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site
title_full_unstemmed	Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site
title_sort	cancer incidence in thyborøn-harboøre, denmark: a cohort study from an industrially contaminated site
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b023ebd9597645179c246451aba99539
work_keys_str_mv	AT elsebethlynge cancerincidenceinthyborønharboøredenmarkacohortstudyfromanindustriallycontaminatedsite AT hansasgerholmsgaard cancerincidenceinthyborønharboøredenmarkacohortstudyfromanindustriallycontaminatedsite AT thereselfholmager cancerincidenceinthyborønharboøredenmarkacohortstudyfromanindustriallycontaminatedsite AT sørenlophaven cancerincidenceinthyborønharboøredenmarkacohortstudyfromanindustriallycontaminatedsite
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Cancer incidence in Thyborøn-Harboøre, Denmark: a cohort study from an industrially contaminated site

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