Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules

Kinesin-14s, such as Ncd, interact with microtubules with their non-processive motor domains and their diffusive tail domains, but the influence of the tail domains on motor performance is not known. Here the authors show that tail domain slippage limits the velocities and forces generated by Ncd, s...

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Autores principales:	Annemarie Lüdecke, Anja-Maria Seidel, Marcus Braun, Zdenek Lansky, Stefan Diez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b025a17c0c624b77839a6abd8efb96b0
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spelling	oai:doaj.org-article:b025a17c0c624b77839a6abd8efb96b02021-12-02T17:32:14ZDiffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules10.1038/s41467-018-04656-02041-1723https://doaj.org/article/b025a17c0c624b77839a6abd8efb96b02018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04656-0https://doaj.org/toc/2041-1723Kinesin-14s, such as Ncd, interact with microtubules with their non-processive motor domains and their diffusive tail domains, but the influence of the tail domains on motor performance is not known. Here the authors show that tail domain slippage limits the velocities and forces generated by Ncd, suggesting it acts as a slippery crosslinker.Annemarie LüdeckeAnja-Maria SeidelMarcus BraunZdenek LanskyStefan DiezNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annemarie Lüdecke Anja-Maria Seidel Marcus Braun Zdenek Lansky Stefan Diez Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
description	Kinesin-14s, such as Ncd, interact with microtubules with their non-processive motor domains and their diffusive tail domains, but the influence of the tail domains on motor performance is not known. Here the authors show that tail domain slippage limits the velocities and forces generated by Ncd, suggesting it acts as a slippery crosslinker.
format	article
author	Annemarie Lüdecke Anja-Maria Seidel Marcus Braun Zdenek Lansky Stefan Diez
author_facet	Annemarie Lüdecke Anja-Maria Seidel Marcus Braun Zdenek Lansky Stefan Diez
author_sort	Annemarie Lüdecke
title	Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_short	Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_full	Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_fullStr	Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_full_unstemmed	Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
title_sort	diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b025a17c0c624b77839a6abd8efb96b0
work_keys_str_mv	AT annemarieludecke diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules AT anjamariaseidel diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules AT marcusbraun diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules AT zdeneklansky diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules AT stefandiez diffusivetailanchoragedeterminesvelocityandforceproducedbykinesin14betweencrosslinkedmicrotubules
_version_	1718380389879250944

Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules

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