Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Biological activity can be photoswitched by light-regulated drugs, but so far only diffusible ligands have been shown to work on endogenous receptors. Here the authors develop targeted covalent photoswitches that couple to a protein target by ligand affinity, and demonstrate photocontrol of GluK1-ex...

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Autores principales:	Mercè Izquierdo-Serra, Antoni Bautista-Barrufet, Ana Trapero, Aida Garrido-Charles, Ariadna Díaz-Tahoces, Nuria Camarero, Silvia Pittolo, Sergio Valbuena, Ariadna Pérez-Jiménez, Marina Gay, Alejandro García-Moll, Carles Rodríguez-Escrich, Juan Lerma, Pedro de la Villa, Eduardo Fernández, Miquel À Pericàs, Amadeu Llebaria, Pau Gorostiza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0268ba0adfb40789719ddb649b48d0f
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spelling	oai:doaj.org-article:b0268ba0adfb40789719ddb649b48d0f2021-12-02T17:32:21ZOptical control of endogenous receptors and cellular excitability using targeted covalent photoswitches10.1038/ncomms122212041-1723https://doaj.org/article/b0268ba0adfb40789719ddb649b48d0f2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12221https://doaj.org/toc/2041-1723Biological activity can be photoswitched by light-regulated drugs, but so far only diffusible ligands have been shown to work on endogenous receptors. Here the authors develop targeted covalent photoswitches that couple to a protein target by ligand affinity, and demonstrate photocontrol of GluK1-expressing neurons.Mercè Izquierdo-SerraAntoni Bautista-BarrufetAna TraperoAida Garrido-CharlesAriadna Díaz-TahocesNuria CamareroSilvia PittoloSergio ValbuenaAriadna Pérez-JiménezMarina GayAlejandro García-MollCarles Rodríguez-EscrichJuan LermaPedro de la VillaEduardo FernándezMiquel À PericàsAmadeu LlebariaPau GorostizaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mercè Izquierdo-Serra Antoni Bautista-Barrufet Ana Trapero Aida Garrido-Charles Ariadna Díaz-Tahoces Nuria Camarero Silvia Pittolo Sergio Valbuena Ariadna Pérez-Jiménez Marina Gay Alejandro García-Moll Carles Rodríguez-Escrich Juan Lerma Pedro de la Villa Eduardo Fernández Miquel À Pericàs Amadeu Llebaria Pau Gorostiza Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
description	Biological activity can be photoswitched by light-regulated drugs, but so far only diffusible ligands have been shown to work on endogenous receptors. Here the authors develop targeted covalent photoswitches that couple to a protein target by ligand affinity, and demonstrate photocontrol of GluK1-expressing neurons.
format	article
author	Mercè Izquierdo-Serra Antoni Bautista-Barrufet Ana Trapero Aida Garrido-Charles Ariadna Díaz-Tahoces Nuria Camarero Silvia Pittolo Sergio Valbuena Ariadna Pérez-Jiménez Marina Gay Alejandro García-Moll Carles Rodríguez-Escrich Juan Lerma Pedro de la Villa Eduardo Fernández Miquel À Pericàs Amadeu Llebaria Pau Gorostiza
author_facet	Mercè Izquierdo-Serra Antoni Bautista-Barrufet Ana Trapero Aida Garrido-Charles Ariadna Díaz-Tahoces Nuria Camarero Silvia Pittolo Sergio Valbuena Ariadna Pérez-Jiménez Marina Gay Alejandro García-Moll Carles Rodríguez-Escrich Juan Lerma Pedro de la Villa Eduardo Fernández Miquel À Pericàs Amadeu Llebaria Pau Gorostiza
author_sort	Mercè Izquierdo-Serra
title	Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
title_short	Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
title_full	Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
title_fullStr	Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
title_full_unstemmed	Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
title_sort	optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b0268ba0adfb40789719ddb649b48d0f
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Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

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