Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Biological activity can be photoswitched by light-regulated drugs, but so far only diffusible ligands have been shown to work on endogenous receptors. Here the authors develop targeted covalent photoswitches that couple to a protein target by ligand affinity, and demonstrate photocontrol of GluK1-ex...

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Main Authors: Mercè Izquierdo-Serra, Antoni Bautista-Barrufet, Ana Trapero, Aida Garrido-Charles, Ariadna Díaz-Tahoces, Nuria Camarero, Silvia Pittolo, Sergio Valbuena, Ariadna Pérez-Jiménez, Marina Gay, Alejandro García-Moll, Carles Rodríguez-Escrich, Juan Lerma, Pedro de la Villa, Eduardo Fernández, Miquel À Pericàs, Amadeu Llebaria, Pau Gorostiza
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/b0268ba0adfb40789719ddb649b48d0f
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https://doaj.org/article/b0268ba0adfb40789719ddb649b48d0f

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