Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis

Thiazole, triazole, thio and semicarbazones are privileged motifs that act as pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB). Tuberculosis (TB) is an infectious disease caused mainly by Mycobacterium tuberculosis and was responsible for 4,000 deaths a day in 20...

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Autores principales:	Cauê Benito Scarim, Fernando Rogério Pavan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Thiazole Triazole Thio and semicarbazones Mycobacterium tuberculosis New compounds Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/b027c5d317da4736bcf8498204e7bf7f
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spelling	oai:doaj.org-article:b027c5d317da4736bcf8498204e7bf7f2021-12-03T04:01:34ZThiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis2772-417410.1016/j.ejmcr.2021.100002https://doaj.org/article/b027c5d317da4736bcf8498204e7bf7f2021-07-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2772417421000029https://doaj.org/toc/2772-4174Thiazole, triazole, thio and semicarbazones are privileged motifs that act as pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB). Tuberculosis (TB) is an infectious disease caused mainly by Mycobacterium tuberculosis and was responsible for 4,000 deaths a day in 2019 worldwide. The resistance and the gap of new drugs is the main cause of the slow drop in TB infections. In this review article, we analyse recent contributions of thiazole, triazole, thio and semicarbazone scaffolds to anti-TB drugs. Beyond these recent trends, we demonstrate the potential of the thiazole, triazole, thio and semicarbazone approach in the medicinal chemistry field of anti-M. tuberculosis drug discovery.Cauê Benito ScarimFernando Rogério PavanElsevierarticleThiazoleTriazoleThio and semicarbazonesMycobacterium tuberculosisNew compoundsPharmacy and materia medicaRS1-441Other systems of medicineRZ201-999ENEuropean Journal of Medicinal Chemistry Reports, Vol 1, Iss , Pp 100002- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Thiazole Triazole Thio and semicarbazones Mycobacterium tuberculosis New compounds Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
spellingShingle	Thiazole Triazole Thio and semicarbazones Mycobacterium tuberculosis New compounds Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999 Cauê Benito Scarim Fernando Rogério Pavan Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis
description	Thiazole, triazole, thio and semicarbazones are privileged motifs that act as pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB). Tuberculosis (TB) is an infectious disease caused mainly by Mycobacterium tuberculosis and was responsible for 4,000 deaths a day in 2019 worldwide. The resistance and the gap of new drugs is the main cause of the slow drop in TB infections. In this review article, we analyse recent contributions of thiazole, triazole, thio and semicarbazone scaffolds to anti-TB drugs. Beyond these recent trends, we demonstrate the potential of the thiazole, triazole, thio and semicarbazone approach in the medicinal chemistry field of anti-M. tuberculosis drug discovery.
format	article
author	Cauê Benito Scarim Fernando Rogério Pavan
author_facet	Cauê Benito Scarim Fernando Rogério Pavan
author_sort	Cauê Benito Scarim
title	Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis
title_short	Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis
title_full	Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis
title_fullStr	Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis
title_full_unstemmed	Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis
title_sort	thiazole, triazole, thio- and semicarbazone derivatives - promising moieties for drug development for the treatment of tuberculosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b027c5d317da4736bcf8498204e7bf7f
work_keys_str_mv	AT cauebenitoscarim thiazoletriazolethioandsemicarbazonederivativespromisingmoietiesfordrugdevelopmentforthetreatmentoftuberculosis AT fernandorogeriopavan thiazoletriazolethioandsemicarbazonederivativespromisingmoietiesfordrugdevelopmentforthetreatmentoftuberculosis
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Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis

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