The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.

<h4>Background</h4>Few clinical data are available on the relationship between genospecies and outcome of Acinetobacter bacteremia, and the results are inconsistent. We performed this study to evaluate the relationship between genospecies and the outcome of Acinetobacter bacteremia.<h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kyung-Hwa Park, Jong-Hee Shin, Seung Yeop Lee, Soo Hyun Kim, Mi Ok Jang, Seung-Ji Kang, Sook-In Jung, Eun-Kyung Chung, Kwan Soo Ko, Hee-Chang Jang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b0294a4656754b33bf4dfe9061ead2f2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b0294a4656754b33bf4dfe9061ead2f2
record_format	dspace
spelling	oai:doaj.org-article:b0294a4656754b33bf4dfe9061ead2f22021-11-18T07:43:15ZThe clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.1932-620310.1371/journal.pone.0065026https://doaj.org/article/b0294a4656754b33bf4dfe9061ead2f22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23755171/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Few clinical data are available on the relationship between genospecies and outcome of Acinetobacter bacteremia, and the results are inconsistent. We performed this study to evaluate the relationship between genospecies and the outcome of Acinetobacter bacteremia.<h4>Methods</h4>Clinical data from 180 patients who had Acinetobacter bacteremia from 2003 to 2010 were reviewed retrospectively. The genospecies were identified by rpoB gene sequence analysis. The clinical features and outcomes of 90 patients with A. baumannii bacteremia were compared to those of 90 patients with non-baumannii Acinetobacter bacteremia (60 with A. nosocomialis, 17 with Acinetobacter species "close to 13 TU", 11 with A. pittii, and two with A. calcoaceticus).<h4>Results</h4>A. baumannii bacteremia was associated with intensive care unit-onset, mechanical ventilation, pneumonia, carbapenem resistance, and higher APACHE II scores, compared to non-baumannii Acinetobacter bacteremia (P<0.05). In univariate analyses, age, pneumonia, multidrug resistance, carbapenem resistance, inappropriate empirical antibiotics, higher APACHE II scores, and A. baumannii genospecies were risk factors for mortality (P<0.05). Multivariate analysis revealed A. baumannii genospecies (OR, 3.60; 95% CI, 1.56-8.33), age, pneumonia, and higher APACHE II scores to be independent risk factors for mortality (P<0.05).<h4>Conclusion</h4>A. baumannii genospecies was an independent risk factor for mortality in patients with Acinetobacter bacteremia. Our results emphasize the importance of correct species identification of Acinetobacter blood isolates.Kyung-Hwa ParkJong-Hee ShinSeung Yeop LeeSoo Hyun KimMi Ok JangSeung-Ji KangSook-In JungEun-Kyung ChungKwan Soo KoHee-Chang JangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65026 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyung-Hwa Park Jong-Hee Shin Seung Yeop Lee Soo Hyun Kim Mi Ok Jang Seung-Ji Kang Sook-In Jung Eun-Kyung Chung Kwan Soo Ko Hee-Chang Jang The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.
description	<h4>Background</h4>Few clinical data are available on the relationship between genospecies and outcome of Acinetobacter bacteremia, and the results are inconsistent. We performed this study to evaluate the relationship between genospecies and the outcome of Acinetobacter bacteremia.<h4>Methods</h4>Clinical data from 180 patients who had Acinetobacter bacteremia from 2003 to 2010 were reviewed retrospectively. The genospecies were identified by rpoB gene sequence analysis. The clinical features and outcomes of 90 patients with A. baumannii bacteremia were compared to those of 90 patients with non-baumannii Acinetobacter bacteremia (60 with A. nosocomialis, 17 with Acinetobacter species "close to 13 TU", 11 with A. pittii, and two with A. calcoaceticus).<h4>Results</h4>A. baumannii bacteremia was associated with intensive care unit-onset, mechanical ventilation, pneumonia, carbapenem resistance, and higher APACHE II scores, compared to non-baumannii Acinetobacter bacteremia (P<0.05). In univariate analyses, age, pneumonia, multidrug resistance, carbapenem resistance, inappropriate empirical antibiotics, higher APACHE II scores, and A. baumannii genospecies were risk factors for mortality (P<0.05). Multivariate analysis revealed A. baumannii genospecies (OR, 3.60; 95% CI, 1.56-8.33), age, pneumonia, and higher APACHE II scores to be independent risk factors for mortality (P<0.05).<h4>Conclusion</h4>A. baumannii genospecies was an independent risk factor for mortality in patients with Acinetobacter bacteremia. Our results emphasize the importance of correct species identification of Acinetobacter blood isolates.
format	article
author	Kyung-Hwa Park Jong-Hee Shin Seung Yeop Lee Soo Hyun Kim Mi Ok Jang Seung-Ji Kang Sook-In Jung Eun-Kyung Chung Kwan Soo Ko Hee-Chang Jang
author_facet	Kyung-Hwa Park Jong-Hee Shin Seung Yeop Lee Soo Hyun Kim Mi Ok Jang Seung-Ji Kang Sook-In Jung Eun-Kyung Chung Kwan Soo Ko Hee-Chang Jang
author_sort	Kyung-Hwa Park
title	The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.
title_short	The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.
title_full	The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.
title_fullStr	The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.
title_full_unstemmed	The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.
title_sort	clinical characteristics, carbapenem resistance, and outcome of acinetobacter bacteremia according to genospecies.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b0294a4656754b33bf4dfe9061ead2f2
work_keys_str_mv	AT kyunghwapark theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT jongheeshin theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT seungyeoplee theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT soohyunkim theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT miokjang theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT seungjikang theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT sookinjung theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT eunkyungchung theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT kwansooko theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT heechangjang theclinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT kyunghwapark clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT jongheeshin clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT seungyeoplee clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT soohyunkim clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT miokjang clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT seungjikang clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT sookinjung clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT eunkyungchung clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT kwansooko clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies AT heechangjang clinicalcharacteristicscarbapenemresistanceandoutcomeofacinetobacterbacteremiaaccordingtogenospecies
_version_	1718423056597123072

The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies.

Ejemplares similares