Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and properdin to discover new PTMs on properdin and der...

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Autores principales:	Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b02ee70614ff4f99a5c217410f8e376c
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spelling	oai:doaj.org-article:b02ee70614ff4f99a5c217410f8e376c2021-12-02T15:35:41ZHybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity10.1038/ncomms133972041-1723https://doaj.org/article/b02ee70614ff4f99a5c217410f8e376c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13397https://doaj.org/toc/2041-1723Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and properdin to discover new PTMs on properdin and derive a biosimilarity score for various sources of EPO.Yang YangFan LiuVojtech FrancLiem Andhyk HalimHuub SchellekensAlbert J. R. HeckNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Yang Fan Liu Vojtech Franc Liem Andhyk Halim Huub Schellekens Albert J. R. Heck Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
description	Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and properdin to discover new PTMs on properdin and derive a biosimilarity score for various sources of EPO.
format	article
author	Yang Yang Fan Liu Vojtech Franc Liem Andhyk Halim Huub Schellekens Albert J. R. Heck
author_facet	Yang Yang Fan Liu Vojtech Franc Liem Andhyk Halim Huub Schellekens Albert J. R. Heck
author_sort	Yang Yang
title	Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
title_short	Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
title_full	Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
title_fullStr	Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
title_full_unstemmed	Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
title_sort	hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b02ee70614ff4f99a5c217410f8e376c
work_keys_str_mv	AT yangyang hybridmassspectrometryapproachesinglycoproteinanalysisandtheirusageinscoringbiosimilarity AT fanliu hybridmassspectrometryapproachesinglycoproteinanalysisandtheirusageinscoringbiosimilarity AT vojtechfranc hybridmassspectrometryapproachesinglycoproteinanalysisandtheirusageinscoringbiosimilarity AT liemandhykhalim hybridmassspectrometryapproachesinglycoproteinanalysisandtheirusageinscoringbiosimilarity AT huubschellekens hybridmassspectrometryapproachesinglycoproteinanalysisandtheirusageinscoringbiosimilarity AT albertjrheck hybridmassspectrometryapproachesinglycoproteinanalysisandtheirusageinscoringbiosimilarity
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Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

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