Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes

Purpose. Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characterist...

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Autores principales:	Lin Fu, Qi Dai, Pengzhi Zhu, Xu Jia, Fangjun Bao, Xiaoyu Chen, Yana Fu, Hengli Lian, Weihua Yang, Yufeng Ye
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b02fb62c7e984c7ba27482d54fc08d53
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spelling	oai:doaj.org-article:b02fb62c7e984c7ba27482d54fc08d532021-11-29T00:56:00ZAssociation between Iris Biological Features and Corneal Biomechanics in Myopic Eyes1875-863010.1155/2021/5866267https://doaj.org/article/b02fb62c7e984c7ba27482d54fc08d532021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5866267https://doaj.org/toc/1875-8630Purpose. Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characteristics. This cross-sectional study evaluated the association between iris surface biological features and corneal biomechanics in young adults with myopia. Methods. We recruited 152 patients with myopia aged ≥18 years, from the Eye Hospital of Wenzhou Medical University, who had complete Corneal Visualization Scheimpflug Technology (Corvis ST) data and graded iris surface features. Iris surface features included crypts, furrows, and color measured from digital slit lamp images. The biomechanical properties of the cornea were assessed using Corvis ST. Only 1 eye of each participant was randomly selected for analysis. Associations between the iris surface features and corneal biomechanics were analyzed using linear regression models. The grade of iris crypts, furrows, and color and corneal biomechanical parameters measured with Corvis ST was the main outcome measures. Results. The iris crypts were significantly associated with deflection amplitude at the first applanation (A1 DLA, β=0.001, P=0.013), A1 delta arc length (A1 dArcL) (β=−0.001, P=0.01), maximum delta arc length (dArcLM) (β=−0.004, P=0.03), and stiffness at the first applanation (SP-A1) (β=−2.092, P=0.016). The iris furrows were only associated with integrated radius (β=−0.212, P=0.025). Iris color was found not related with corneal biomechanical parameters measured via Corvis ST. Conclusions. Iris surface features were associated with corneal biomechanical properties in myopic eyes; more iris crypts were associated with lower corneal stiffness while more extensive furrows were related with higher corneal stiffness. Iris crypts and furrows may provide useful information on corneal biomechanical properties in myopic eyes.Lin FuQi DaiPengzhi ZhuXu JiaFangjun BaoXiaoyu ChenYana FuHengli LianWeihua YangYufeng YeHindawi LimitedarticleMedicine (General)R5-920ENDisease Markers, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lin Fu Qi Dai Pengzhi Zhu Xu Jia Fangjun Bao Xiaoyu Chen Yana Fu Hengli Lian Weihua Yang Yufeng Ye Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
description	Purpose. Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characteristics. This cross-sectional study evaluated the association between iris surface biological features and corneal biomechanics in young adults with myopia. Methods. We recruited 152 patients with myopia aged ≥18 years, from the Eye Hospital of Wenzhou Medical University, who had complete Corneal Visualization Scheimpflug Technology (Corvis ST) data and graded iris surface features. Iris surface features included crypts, furrows, and color measured from digital slit lamp images. The biomechanical properties of the cornea were assessed using Corvis ST. Only 1 eye of each participant was randomly selected for analysis. Associations between the iris surface features and corneal biomechanics were analyzed using linear regression models. The grade of iris crypts, furrows, and color and corneal biomechanical parameters measured with Corvis ST was the main outcome measures. Results. The iris crypts were significantly associated with deflection amplitude at the first applanation (A1 DLA, β=0.001, P=0.013), A1 delta arc length (A1 dArcL) (β=−0.001, P=0.01), maximum delta arc length (dArcLM) (β=−0.004, P=0.03), and stiffness at the first applanation (SP-A1) (β=−2.092, P=0.016). The iris furrows were only associated with integrated radius (β=−0.212, P=0.025). Iris color was found not related with corneal biomechanical parameters measured via Corvis ST. Conclusions. Iris surface features were associated with corneal biomechanical properties in myopic eyes; more iris crypts were associated with lower corneal stiffness while more extensive furrows were related with higher corneal stiffness. Iris crypts and furrows may provide useful information on corneal biomechanical properties in myopic eyes.
format	article
author	Lin Fu Qi Dai Pengzhi Zhu Xu Jia Fangjun Bao Xiaoyu Chen Yana Fu Hengli Lian Weihua Yang Yufeng Ye
author_facet	Lin Fu Qi Dai Pengzhi Zhu Xu Jia Fangjun Bao Xiaoyu Chen Yana Fu Hengli Lian Weihua Yang Yufeng Ye
author_sort	Lin Fu
title	Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_short	Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_full	Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_fullStr	Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_full_unstemmed	Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_sort	association between iris biological features and corneal biomechanics in myopic eyes
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/b02fb62c7e984c7ba27482d54fc08d53
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Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes

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