The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis

Abstract Substantial evidence has shown that epithelial-mesenchymal transition (EMT) plays critical roles in colorectal cancer (CRC) development and prognosis. To uncover the pivotal regulators that function in the cooperative interactions between cancer cells and their microenvironment and conseque...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hui Li, Anjing Zhong, Si Li, Xianwen Meng, Xue Wang, Fangying Xu, Maode Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b03084c2fcf64c00abeb63ca9d6184ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b03084c2fcf64c00abeb63ca9d6184ca
record_format	dspace
spelling	oai:doaj.org-article:b03084c2fcf64c00abeb63ca9d6184ca2021-12-02T11:52:27ZThe integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis10.1038/s41598-017-05280-62045-2322https://doaj.org/article/b03084c2fcf64c00abeb63ca9d6184ca2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05280-6https://doaj.org/toc/2045-2322Abstract Substantial evidence has shown that epithelial-mesenchymal transition (EMT) plays critical roles in colorectal cancer (CRC) development and prognosis. To uncover the pivotal regulators that function in the cooperative interactions between cancer cells and their microenvironment and consequently affect the EMT process, we carried out a systematic analysis and evaluated prognosis in CRC specimens. Tumor buds and their surrounding stroma were captured using laser microdissection. We used gene expression profiling, bioinformatics analysis and regulatory network construction for molecular selection. The clinical significance of potential biomarkers was investigated. We identified potential EMT biomarkers, including BGN, MMP1, LGALS1, SERPINB5, and TM4SF4, all of which participated in the integrated pathway of TGFβ/Snail with TNFα/NFκB. We also found that BGN, MMP1, LGALS1, SERPINB5 and TM4SF4 were related to CRC patient prognosis. Patients with higher expression of these individual potential biomarkers had poorer prognosis. Among the identified biomarkers, BGN and TM4SF4 are reported, for the first time, to probably be involved in the EMT process and to predict CRC prognosis. Our results strongly suggest that the integrated pathway of TGFβ/Snail with TNFα/NFκB may be the principal axis that links cancer cells to their microenvironment during the EMT process and results in poor prognosis in CRC patients.Hui LiAnjing ZhongSi LiXianwen MengXue WangFangying XuMaode LaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui Li Anjing Zhong Si Li Xianwen Meng Xue Wang Fangying Xu Maode Lai The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis
description	Abstract Substantial evidence has shown that epithelial-mesenchymal transition (EMT) plays critical roles in colorectal cancer (CRC) development and prognosis. To uncover the pivotal regulators that function in the cooperative interactions between cancer cells and their microenvironment and consequently affect the EMT process, we carried out a systematic analysis and evaluated prognosis in CRC specimens. Tumor buds and their surrounding stroma were captured using laser microdissection. We used gene expression profiling, bioinformatics analysis and regulatory network construction for molecular selection. The clinical significance of potential biomarkers was investigated. We identified potential EMT biomarkers, including BGN, MMP1, LGALS1, SERPINB5, and TM4SF4, all of which participated in the integrated pathway of TGFβ/Snail with TNFα/NFκB. We also found that BGN, MMP1, LGALS1, SERPINB5 and TM4SF4 were related to CRC patient prognosis. Patients with higher expression of these individual potential biomarkers had poorer prognosis. Among the identified biomarkers, BGN and TM4SF4 are reported, for the first time, to probably be involved in the EMT process and to predict CRC prognosis. Our results strongly suggest that the integrated pathway of TGFβ/Snail with TNFα/NFκB may be the principal axis that links cancer cells to their microenvironment during the EMT process and results in poor prognosis in CRC patients.
format	article
author	Hui Li Anjing Zhong Si Li Xianwen Meng Xue Wang Fangying Xu Maode Lai
author_facet	Hui Li Anjing Zhong Si Li Xianwen Meng Xue Wang Fangying Xu Maode Lai
author_sort	Hui Li
title	The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis
title_short	The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis
title_full	The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis
title_fullStr	The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis
title_full_unstemmed	The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis
title_sort	integrated pathway of tgfβ/snail with tnfα/nfκb may facilitate the tumor-stroma interaction in the emt process and colorectal cancer prognosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b03084c2fcf64c00abeb63ca9d6184ca
work_keys_str_mv	AT huili theintegratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT anjingzhong theintegratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT sili theintegratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT xianwenmeng theintegratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT xuewang theintegratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT fangyingxu theintegratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT maodelai theintegratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT huili integratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT anjingzhong integratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT sili integratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT xianwenmeng integratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT xuewang integratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT fangyingxu integratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis AT maodelai integratedpathwayoftgfbsnailwithtnfanfkbmayfacilitatethetumorstromainteractionintheemtprocessandcolorectalcancerprognosis
_version_	1718395062920937472

The integrated pathway of TGFβ/Snail with TNFα/NFκB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis

Ejemplares similares