Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches

Abstract The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight...

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Autores principales:	Giorgia Gioacchini, Giacomo Rossi, Oliana Carnevali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b0308e12f1e648e4a6b976a9a309754e
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spelling	oai:doaj.org-article:b0308e12f1e648e4a6b976a9a309754e2021-12-02T15:06:20ZHost-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches10.1038/s41598-017-01322-12045-2322https://doaj.org/article/b0308e12f1e648e4a6b976a9a309754e2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01322-1https://doaj.org/toc/2045-2322Abstract The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight the potential of this probiotic mixture to regulate immune cell function, by inducing gene expression of toll-like receptors and other immune related molecules. Furthermore, TUNEL assay showed a decrease in the number of apoptotic cells, and this finding was supported by a reduction in pro-apoptotic factors and an increase in anti-apoptotic molecules. The results presented here strengthen the molecular mechanisms activated by probiotic mix controlling immune response and inflammation.Giorgia GioacchiniGiacomo RossiOliana CarnevaliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giorgia Gioacchini Giacomo Rossi Oliana Carnevali Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
description	Abstract The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight the potential of this probiotic mixture to regulate immune cell function, by inducing gene expression of toll-like receptors and other immune related molecules. Furthermore, TUNEL assay showed a decrease in the number of apoptotic cells, and this finding was supported by a reduction in pro-apoptotic factors and an increase in anti-apoptotic molecules. The results presented here strengthen the molecular mechanisms activated by probiotic mix controlling immune response and inflammation.
format	article
author	Giorgia Gioacchini Giacomo Rossi Oliana Carnevali
author_facet	Giorgia Gioacchini Giacomo Rossi Oliana Carnevali
author_sort	Giorgia Gioacchini
title	Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
title_short	Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
title_full	Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
title_fullStr	Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
title_full_unstemmed	Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
title_sort	host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b0308e12f1e648e4a6b976a9a309754e
work_keys_str_mv	AT giorgiagioacchini hostprobioticinteractionnewinsightintotheroleoftheendocannabinoidsystembyinvivoandexvivoapproaches AT giacomorossi hostprobioticinteractionnewinsightintotheroleoftheendocannabinoidsystembyinvivoandexvivoapproaches AT olianacarnevali hostprobioticinteractionnewinsightintotheroleoftheendocannabinoidsystembyinvivoandexvivoapproaches
_version_	1718388537221447680

Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches

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