Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.

Understanding the interaction between the nervous system and cerebral vasculature is fundamental to forming a complete picture of the neurophysiology of sleep and its role in maintaining physiological homeostasis. However, the intrinsic hemodynamics of slow-wave sleep (SWS) are still poorly known. W...

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Autores principales:	Tiina Näsi, Jaakko Virtanen, Tommi Noponen, Jussi Toppila, Tapani Salmi, Risto J Ilmoniemi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b0355a3411ea45308a11d2b8a5c6ce1c
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spelling	oai:doaj.org-article:b0355a3411ea45308a11d2b8a5c6ce1c2021-11-18T07:36:25ZSpontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.1932-620310.1371/journal.pone.0025415https://doaj.org/article/b0355a3411ea45308a11d2b8a5c6ce1c2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22043284/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Understanding the interaction between the nervous system and cerebral vasculature is fundamental to forming a complete picture of the neurophysiology of sleep and its role in maintaining physiological homeostasis. However, the intrinsic hemodynamics of slow-wave sleep (SWS) are still poorly known. We carried out 30 all-night sleep measurements with combined near-infrared spectroscopy (NIRS) and polysomnography to investigate spontaneous hemodynamic behavior in SWS compared to light (LS) and rapid-eye-movement sleep (REM). In particular, we concentrated on slow oscillations (3-150 mHz) in oxy- and deoxyhemoglobin concentrations, heart rate, arterial oxygen saturation, and the pulsation amplitude of the photoplethysmographic signal. We also analyzed the behavior of these variables during sleep stage transitions. The results indicate that slow spontaneous cortical and systemic hemodynamic activity is reduced in SWS compared to LS, REM, and wakefulness. This behavior may be explained by neuronal synchronization observed in electrophysiological studies of SWS and a reduction in autonomic nervous system activity. Also, sleep stage transitions are asymmetric, so that the SWS-to-LS and LS-to-REM transitions, which are associated with an increase in the complexity of cortical electrophysiological activity, are characterized by more dramatic hemodynamic changes than the opposite transitions. Thus, it appears that while the onset of SWS and termination of REM occur only as gradual processes over time, the termination of SWS and onset of REM may be triggered more abruptly by a particular physiological event or condition. The results suggest that scalp hemodynamic changes should be considered alongside cortical hemodynamic changes in NIRS sleep studies to assess the interaction between the autonomic and central nervous systems.Tiina NäsiJaakko VirtanenTommi NoponenJussi ToppilaTapani SalmiRisto J IlmoniemiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e25415 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiina Näsi Jaakko Virtanen Tommi Noponen Jussi Toppila Tapani Salmi Risto J Ilmoniemi Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.
description	Understanding the interaction between the nervous system and cerebral vasculature is fundamental to forming a complete picture of the neurophysiology of sleep and its role in maintaining physiological homeostasis. However, the intrinsic hemodynamics of slow-wave sleep (SWS) are still poorly known. We carried out 30 all-night sleep measurements with combined near-infrared spectroscopy (NIRS) and polysomnography to investigate spontaneous hemodynamic behavior in SWS compared to light (LS) and rapid-eye-movement sleep (REM). In particular, we concentrated on slow oscillations (3-150 mHz) in oxy- and deoxyhemoglobin concentrations, heart rate, arterial oxygen saturation, and the pulsation amplitude of the photoplethysmographic signal. We also analyzed the behavior of these variables during sleep stage transitions. The results indicate that slow spontaneous cortical and systemic hemodynamic activity is reduced in SWS compared to LS, REM, and wakefulness. This behavior may be explained by neuronal synchronization observed in electrophysiological studies of SWS and a reduction in autonomic nervous system activity. Also, sleep stage transitions are asymmetric, so that the SWS-to-LS and LS-to-REM transitions, which are associated with an increase in the complexity of cortical electrophysiological activity, are characterized by more dramatic hemodynamic changes than the opposite transitions. Thus, it appears that while the onset of SWS and termination of REM occur only as gradual processes over time, the termination of SWS and onset of REM may be triggered more abruptly by a particular physiological event or condition. The results suggest that scalp hemodynamic changes should be considered alongside cortical hemodynamic changes in NIRS sleep studies to assess the interaction between the autonomic and central nervous systems.
format	article
author	Tiina Näsi Jaakko Virtanen Tommi Noponen Jussi Toppila Tapani Salmi Risto J Ilmoniemi
author_facet	Tiina Näsi Jaakko Virtanen Tommi Noponen Jussi Toppila Tapani Salmi Risto J Ilmoniemi
author_sort	Tiina Näsi
title	Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.
title_short	Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.
title_full	Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.
title_fullStr	Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.
title_full_unstemmed	Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.
title_sort	spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/b0355a3411ea45308a11d2b8a5c6ce1c
work_keys_str_mv	AT tiinanasi spontaneoushemodynamicoscillationsduringhumansleepandsleepstagetransitionscharacterizedwithnearinfraredspectroscopy AT jaakkovirtanen spontaneoushemodynamicoscillationsduringhumansleepandsleepstagetransitionscharacterizedwithnearinfraredspectroscopy AT tomminoponen spontaneoushemodynamicoscillationsduringhumansleepandsleepstagetransitionscharacterizedwithnearinfraredspectroscopy AT jussitoppila spontaneoushemodynamicoscillationsduringhumansleepandsleepstagetransitionscharacterizedwithnearinfraredspectroscopy AT tapanisalmi spontaneoushemodynamicoscillationsduringhumansleepandsleepstagetransitionscharacterizedwithnearinfraredspectroscopy AT ristojilmoniemi spontaneoushemodynamicoscillationsduringhumansleepandsleepstagetransitionscharacterizedwithnearinfraredspectroscopy
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Spontaneous hemodynamic oscillations during human sleep and sleep stage transitions characterized with near-infrared spectroscopy.

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