Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Heng Zhou, Xinghu Zhang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China Aim: Our aim was to study the clinical features of postoperative meningitis after neurosurgery and identify the factors affecting the duration of tr...

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Autores principales: Zhou H, Zhang XH
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/b03eaf24b6a84a538c181c3251f07f75
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spelling oai:doaj.org-article:b03eaf24b6a84a538c181c3251f07f752021-12-02T04:59:05ZIntracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection1178-2021https://doaj.org/article/b03eaf24b6a84a538c181c3251f07f752014-11-01T00:00:00Zhttp://www.dovepress.com/intracranial-malignant-lesions-correlate-with-the-requirement-for-a-lo-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Heng Zhou, Xinghu Zhang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China Aim: Our aim was to study the clinical features of postoperative meningitis after neurosurgery and identify the factors affecting the duration of treatment.Methods: This retrospective study assessed 283 patients with postoperative bacterial meningitis in the Neurosurgery Department of Beijing Tiantan Hospital, Beijing, People’s Republic of China, between January and December 2012. Patients’ clinical data were reviewed, and multivariate logistic regression analysis was used to identify the factors associated with a prolonged treatment course.Results: The mortality rate was 0.4% in these patients, of whom 12.4% were found with pathogens in the cerebrospinal fluid. Among the three most common pathogens detected were methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, and Pseudomonas aeruginosa. The mean treatment course was 13.5±2.1 days. Interestingly, the treatment duration for postoperative meningitis was significantly longer in patients with intracranial malignant tumors than in those with benign lesions. Single-factor analysis showed that male sex (P=0.042) and malignant (rather than benign) lesions (P<0.001) were significantly associated with prolonged treatment duration. Multivariate analysis further confirmed that malignant intracranial lesions represented an independent risk factor for prolonged treatment duration (odds ratio: 2.5962; 95% confidence interval: 1.1092–6.6134).Conclusion: The nature of the intracranial lesion is an independent risk factor for the duration of treatment in postoperative meningitis after neurosurgery. Keywords: Acinetobacter baumannii, cerebrospinal fluid, intracranial malignant tumors, methicillin-resistant Staphylococcus aureus, postoperative meningitis, Pseudomonas aeruginosaZhou HZhang XHDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 2071-2077 (2014)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Zhou H
Zhang XH
Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection
description Heng Zhou, Xinghu Zhang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China Aim: Our aim was to study the clinical features of postoperative meningitis after neurosurgery and identify the factors affecting the duration of treatment.Methods: This retrospective study assessed 283 patients with postoperative bacterial meningitis in the Neurosurgery Department of Beijing Tiantan Hospital, Beijing, People’s Republic of China, between January and December 2012. Patients’ clinical data were reviewed, and multivariate logistic regression analysis was used to identify the factors associated with a prolonged treatment course.Results: The mortality rate was 0.4% in these patients, of whom 12.4% were found with pathogens in the cerebrospinal fluid. Among the three most common pathogens detected were methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, and Pseudomonas aeruginosa. The mean treatment course was 13.5±2.1 days. Interestingly, the treatment duration for postoperative meningitis was significantly longer in patients with intracranial malignant tumors than in those with benign lesions. Single-factor analysis showed that male sex (P=0.042) and malignant (rather than benign) lesions (P<0.001) were significantly associated with prolonged treatment duration. Multivariate analysis further confirmed that malignant intracranial lesions represented an independent risk factor for prolonged treatment duration (odds ratio: 2.5962; 95% confidence interval: 1.1092–6.6134).Conclusion: The nature of the intracranial lesion is an independent risk factor for the duration of treatment in postoperative meningitis after neurosurgery. Keywords: Acinetobacter baumannii, cerebrospinal fluid, intracranial malignant tumors, methicillin-resistant Staphylococcus aureus, postoperative meningitis, Pseudomonas aeruginosa
format article
author Zhou H
Zhang XH
author_facet Zhou H
Zhang XH
author_sort Zhou H
title Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection
title_short Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection
title_full Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection
title_fullStr Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection
title_full_unstemmed Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection
title_sort intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/b03eaf24b6a84a538c181c3251f07f75
work_keys_str_mv AT zhouh intracranialmalignantlesionscorrelatewiththerequirementforalongtreatmentcourseinnbsppostoperativecentralnervoussysteminfection
AT zhangxh intracranialmalignantlesionscorrelatewiththerequirementforalongtreatmentcourseinnbsppostoperativecentralnervoussysteminfection
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