Ecological networking of cystic fibrosis lung infections

Cystic fibrosis: the role of microbial ecology Studying the varying ecology of complex microbial infections in the lungs may help guide treatment options in cystic fibrosis. The disease is complicated due to infection with a diverse community of pathogenic microorganisms. The success of treatments b...

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Autores principales:	Robert A Quinn, Katrine Whiteson, Yan Wei Lim, Jiangchao Zhao, Douglas Conrad, John J LiPuma, Forest Rohwer, Stefanie Widder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/b03f289b0e434179b021942ff357763a
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spelling	oai:doaj.org-article:b03f289b0e434179b021942ff357763a2021-12-02T11:42:16ZEcological networking of cystic fibrosis lung infections10.1038/s41522-016-0002-12055-5008https://doaj.org/article/b03f289b0e434179b021942ff357763a2016-12-01T00:00:00Zhttps://doi.org/10.1038/s41522-016-0002-1https://doaj.org/toc/2055-5008Cystic fibrosis: the role of microbial ecology Studying the varying ecology of complex microbial infections in the lungs may help guide treatment options in cystic fibrosis. The disease is complicated due to infection with a diverse community of pathogenic microorganisms. The success of treatments based on identifying and targeting specific microbes can be unpredictable due to the effects of interactions within the mixed microbial ecosystem. Stefanie Widder at the University of Vienna together with Robert Quinn and co-workers in the USA, studied these interactions in six specific cases of cystic fibrosis using lung infection samples gathered over 10 years. They identified three main groups of bacteria involved and developed several hypotheses about inter-relationships that can affect the success of antibiotic treatments. The researchers argue that their new hypotheses and overall ‘ecological theory’ will lead to more-reliable predictions of the likely benefits of specific treatment regimes.Robert A QuinnKatrine WhitesonYan Wei LimJiangchao ZhaoDouglas ConradJohn J LiPumaForest RohwerStefanie WidderNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 2, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Robert A Quinn Katrine Whiteson Yan Wei Lim Jiangchao Zhao Douglas Conrad John J LiPuma Forest Rohwer Stefanie Widder Ecological networking of cystic fibrosis lung infections
description	Cystic fibrosis: the role of microbial ecology Studying the varying ecology of complex microbial infections in the lungs may help guide treatment options in cystic fibrosis. The disease is complicated due to infection with a diverse community of pathogenic microorganisms. The success of treatments based on identifying and targeting specific microbes can be unpredictable due to the effects of interactions within the mixed microbial ecosystem. Stefanie Widder at the University of Vienna together with Robert Quinn and co-workers in the USA, studied these interactions in six specific cases of cystic fibrosis using lung infection samples gathered over 10 years. They identified three main groups of bacteria involved and developed several hypotheses about inter-relationships that can affect the success of antibiotic treatments. The researchers argue that their new hypotheses and overall ‘ecological theory’ will lead to more-reliable predictions of the likely benefits of specific treatment regimes.
format	article
author	Robert A Quinn Katrine Whiteson Yan Wei Lim Jiangchao Zhao Douglas Conrad John J LiPuma Forest Rohwer Stefanie Widder
author_facet	Robert A Quinn Katrine Whiteson Yan Wei Lim Jiangchao Zhao Douglas Conrad John J LiPuma Forest Rohwer Stefanie Widder
author_sort	Robert A Quinn
title	Ecological networking of cystic fibrosis lung infections
title_short	Ecological networking of cystic fibrosis lung infections
title_full	Ecological networking of cystic fibrosis lung infections
title_fullStr	Ecological networking of cystic fibrosis lung infections
title_full_unstemmed	Ecological networking of cystic fibrosis lung infections
title_sort	ecological networking of cystic fibrosis lung infections
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b03f289b0e434179b021942ff357763a
work_keys_str_mv	AT robertaquinn ecologicalnetworkingofcysticfibrosislunginfections AT katrinewhiteson ecologicalnetworkingofcysticfibrosislunginfections AT yanweilim ecologicalnetworkingofcysticfibrosislunginfections AT jiangchaozhao ecologicalnetworkingofcysticfibrosislunginfections AT douglasconrad ecologicalnetworkingofcysticfibrosislunginfections AT johnjlipuma ecologicalnetworkingofcysticfibrosislunginfections AT forestrohwer ecologicalnetworkingofcysticfibrosislunginfections AT stefaniewidder ecologicalnetworkingofcysticfibrosislunginfections
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Ecological networking of cystic fibrosis lung infections

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