Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database
Primary Sjögren’s syndrome (pSS) is an autoimmune disease, associated with a high risk of lymphoma. Mounting evidence suggests that cardiovascular morbidity and mortality are higher in patients with pSS, although data are heterogeneous. The aim of this study was to assess whether pSS patients are at...
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MDPI AG
2021
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oai:doaj.org-article:b040b161a75f4953a5fbea28d0e8ea042021-11-11T17:44:10ZCardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database10.3390/jcm102151152077-0383https://doaj.org/article/b040b161a75f4953a5fbea28d0e8ea042021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5115https://doaj.org/toc/2077-0383Primary Sjögren’s syndrome (pSS) is an autoimmune disease, associated with a high risk of lymphoma. Mounting evidence suggests that cardiovascular morbidity and mortality are higher in patients with pSS, although data are heterogeneous. The aim of this study was to assess whether pSS patients are at higher risk of hospitalisation for cardiovascular events (CVEs), venous thromboembolic events (VTEs), pulmonary hypertension (PH), and sleep apnoea syndrome (SAS). Through a nationwide population-based retrospective study using the French health insurance database, we selected new-onset pSS in-patients hospitalised between 2011 and 2018. We compared the incidence of CVEs (ischemic heart diseases (IHDs), strokes, and heart failure), SAS, VTEs, and PH with an age- and sex-matched (1:10) hospitalised control group. The calculations of adjusted hazard ratios (aHR) included available confounding factors. We studied 25,661 patients hospitalised for pSS compared with 252,543 matched patients. The incidence of hospitalisation for IHD, SAS, and PH was significantly higher in pSS patients (aHR: 1.20 (1.06–1.34); <i>p</i> = 0.003, aHR: 1.97 (1.70–2.28); <i>p</i> < 0.001, and aHR: 3.32 (2.10–5.25); <i>p</i> < 0.001, respectively), whereas the incidence of stroke, heart failure, and VTE was the same between groups. Further prospective studies are needed to confirm these results and to explore the pathophysiological mechanisms involved.Radjiv GoulabchandCamille RoubilleDavid MontaniPierre FeslerArnaud BourdinNicolas MalafayeJacques MorelErik ArnaudBenoit LattucaLucie BarateauPhilippe GuilpainThibault MuraMDPI AGarticleSjögren’s syndromecardiovascular diseasesischemic heart diseasessleep apnoea syndromevenous thromboembolic eventspulmonary hypertensionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5115, p 5115 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Sjögren’s syndrome cardiovascular diseases ischemic heart diseases sleep apnoea syndrome venous thromboembolic events pulmonary hypertension Medicine R |
| spellingShingle |
Sjögren’s syndrome cardiovascular diseases ischemic heart diseases sleep apnoea syndrome venous thromboembolic events pulmonary hypertension Medicine R Radjiv Goulabchand Camille Roubille David Montani Pierre Fesler Arnaud Bourdin Nicolas Malafaye Jacques Morel Erik Arnaud Benoit Lattuca Lucie Barateau Philippe Guilpain Thibault Mura Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database |
| description |
Primary Sjögren’s syndrome (pSS) is an autoimmune disease, associated with a high risk of lymphoma. Mounting evidence suggests that cardiovascular morbidity and mortality are higher in patients with pSS, although data are heterogeneous. The aim of this study was to assess whether pSS patients are at higher risk of hospitalisation for cardiovascular events (CVEs), venous thromboembolic events (VTEs), pulmonary hypertension (PH), and sleep apnoea syndrome (SAS). Through a nationwide population-based retrospective study using the French health insurance database, we selected new-onset pSS in-patients hospitalised between 2011 and 2018. We compared the incidence of CVEs (ischemic heart diseases (IHDs), strokes, and heart failure), SAS, VTEs, and PH with an age- and sex-matched (1:10) hospitalised control group. The calculations of adjusted hazard ratios (aHR) included available confounding factors. We studied 25,661 patients hospitalised for pSS compared with 252,543 matched patients. The incidence of hospitalisation for IHD, SAS, and PH was significantly higher in pSS patients (aHR: 1.20 (1.06–1.34); <i>p</i> = 0.003, aHR: 1.97 (1.70–2.28); <i>p</i> < 0.001, and aHR: 3.32 (2.10–5.25); <i>p</i> < 0.001, respectively), whereas the incidence of stroke, heart failure, and VTE was the same between groups. Further prospective studies are needed to confirm these results and to explore the pathophysiological mechanisms involved. |
| format |
article |
| author |
Radjiv Goulabchand Camille Roubille David Montani Pierre Fesler Arnaud Bourdin Nicolas Malafaye Jacques Morel Erik Arnaud Benoit Lattuca Lucie Barateau Philippe Guilpain Thibault Mura |
| author_facet |
Radjiv Goulabchand Camille Roubille David Montani Pierre Fesler Arnaud Bourdin Nicolas Malafaye Jacques Morel Erik Arnaud Benoit Lattuca Lucie Barateau Philippe Guilpain Thibault Mura |
| author_sort |
Radjiv Goulabchand |
| title |
Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database |
| title_short |
Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database |
| title_full |
Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database |
| title_fullStr |
Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database |
| title_full_unstemmed |
Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database |
| title_sort |
cardiovascular events, sleep apnoea, and pulmonary hypertension in primary sjögren’s syndrome: data from the french health insurance database |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/b040b161a75f4953a5fbea28d0e8ea04 |
| work_keys_str_mv |
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