Ultrasonic predictors of macrosomia in gestational diabetes mellitus

BACKGROUND: The basis of early ultrasound (US) diagnosis of diabetic fetopathy (DF) in pregnant with gestational diabetes mellitus (GDM) is the forehanded detection of macrosomia, especially its asymmetric forms. In pregnant with GDM on a diet therapy, the detection of macrosomia may be an indicatio...

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Autores principales: Sergey N. Lysenko, Marina A. Chechneva, Fatima F. Burumkulova, Vasily A. Petrukhin, Anton E. Panov, Margarita A. Plechanova, Victoria I. Ulyatovskaya, Natalia A. Zubkova, Anatoliy N. Tyulpakov
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Publicado: Endocrinology Research Centre 2019
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spelling oai:doaj.org-article:b0478a24092941008369ed5de1b04b8f2021-11-14T09:00:22ZUltrasonic predictors of macrosomia in gestational diabetes mellitus2072-03512072-037810.14341/DM10109https://doaj.org/article/b0478a24092941008369ed5de1b04b8f2019-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10109https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: The basis of early ultrasound (US) diagnosis of diabetic fetopathy (DF) in pregnant with gestational diabetes mellitus (GDM) is the forehanded detection of macrosomia, especially its asymmetric forms. In pregnant with GDM on a diet therapy, the detection of macrosomia may be an indication for starting the insulin therapy. In pregnant with hyperglycemia due to mutation in the glucokinase gene (GCK), US fetal growth dynamics helps to assume the fetal genotype, as well as to stratify the risks of insulin therapy. AIM: To determine the prognostic significance of asymmetric form of macrosomia and the value of the coefficients of proportionality for the diagnosis of DF in pregnant with GDM, including hyperglycemia due to mutation in the GCK gene. MATERIALS AND METHODS: US fetometry was performed in 95 pregnant with GDM (including 22 pregnant with hyperglycemia caused by mutation in the GCK gene) (main group) and 427 healthy pregnant women (control group). Estimated fetal weight, standard fetometric indicators and coefficients of proportionality were evaluated. Retrospective analysis of US predictors of macrosomia was carried out after evaluating the weight of the newborn and clarifying the signs of DF. RESULTS: In the group with GDM, 51 (53.7%) pregnant had children with phenotypic symptoms of DF, including macrosomia – 66,7% (34 children). We found statistically significant differences in fetal weight between the control group and the main group who gave birth to children with DF starting from 32 weeks. The coefficients of proportionality (femur length/abdominal circumference and the head circumference/abdominal circumference), characterizing the formation of the asymmetric macrosomia were significantly from 34 weeks (Р<0,05). CONCLUSION: The most effective predictive fetometric indicators for the diagnosis of fetal macrosomia are the dimensions of fetal abdomen and fetal weight > 90 percentile for gestational age. A specific sign of DF in pregnant with GDM is the asymmetric macrosomia. In pregnant with a mutation in the GCK gene, the tendency to macrosomia was revealed only in the absence of a mutation in the fetus, but insulin therapy in the presence of a similar mutation in fetus did not lead to a significant decrease in its percentile ranges.Sergey N. LysenkoMarina A. ChechnevaFatima F. BurumkulovaVasily A. PetrukhinAnton E. PanovMargarita A. PlechanovaVictoria I. UlyatovskayaNatalia A. ZubkovaAnatoliy N. TyulpakovEndocrinology Research Centrearticlegestational diabetes mellitusdiabetic fetopathymacrosomiamonogenic diabetesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 4, Pp 358-366 (2019)
institution DOAJ
collection DOAJ
language EN
RU
topic gestational diabetes mellitus
diabetic fetopathy
macrosomia
monogenic diabetes
Nutritional diseases. Deficiency diseases
RC620-627
spellingShingle gestational diabetes mellitus
diabetic fetopathy
macrosomia
monogenic diabetes
Nutritional diseases. Deficiency diseases
RC620-627
Sergey N. Lysenko
Marina A. Chechneva
Fatima F. Burumkulova
Vasily A. Petrukhin
Anton E. Panov
Margarita A. Plechanova
Victoria I. Ulyatovskaya
Natalia A. Zubkova
Anatoliy N. Tyulpakov
Ultrasonic predictors of macrosomia in gestational diabetes mellitus
description BACKGROUND: The basis of early ultrasound (US) diagnosis of diabetic fetopathy (DF) in pregnant with gestational diabetes mellitus (GDM) is the forehanded detection of macrosomia, especially its asymmetric forms. In pregnant with GDM on a diet therapy, the detection of macrosomia may be an indication for starting the insulin therapy. In pregnant with hyperglycemia due to mutation in the glucokinase gene (GCK), US fetal growth dynamics helps to assume the fetal genotype, as well as to stratify the risks of insulin therapy. AIM: To determine the prognostic significance of asymmetric form of macrosomia and the value of the coefficients of proportionality for the diagnosis of DF in pregnant with GDM, including hyperglycemia due to mutation in the GCK gene. MATERIALS AND METHODS: US fetometry was performed in 95 pregnant with GDM (including 22 pregnant with hyperglycemia caused by mutation in the GCK gene) (main group) and 427 healthy pregnant women (control group). Estimated fetal weight, standard fetometric indicators and coefficients of proportionality were evaluated. Retrospective analysis of US predictors of macrosomia was carried out after evaluating the weight of the newborn and clarifying the signs of DF. RESULTS: In the group with GDM, 51 (53.7%) pregnant had children with phenotypic symptoms of DF, including macrosomia – 66,7% (34 children). We found statistically significant differences in fetal weight between the control group and the main group who gave birth to children with DF starting from 32 weeks. The coefficients of proportionality (femur length/abdominal circumference and the head circumference/abdominal circumference), characterizing the formation of the asymmetric macrosomia were significantly from 34 weeks (Р<0,05). CONCLUSION: The most effective predictive fetometric indicators for the diagnosis of fetal macrosomia are the dimensions of fetal abdomen and fetal weight > 90 percentile for gestational age. A specific sign of DF in pregnant with GDM is the asymmetric macrosomia. In pregnant with a mutation in the GCK gene, the tendency to macrosomia was revealed only in the absence of a mutation in the fetus, but insulin therapy in the presence of a similar mutation in fetus did not lead to a significant decrease in its percentile ranges.
format article
author Sergey N. Lysenko
Marina A. Chechneva
Fatima F. Burumkulova
Vasily A. Petrukhin
Anton E. Panov
Margarita A. Plechanova
Victoria I. Ulyatovskaya
Natalia A. Zubkova
Anatoliy N. Tyulpakov
author_facet Sergey N. Lysenko
Marina A. Chechneva
Fatima F. Burumkulova
Vasily A. Petrukhin
Anton E. Panov
Margarita A. Plechanova
Victoria I. Ulyatovskaya
Natalia A. Zubkova
Anatoliy N. Tyulpakov
author_sort Sergey N. Lysenko
title Ultrasonic predictors of macrosomia in gestational diabetes mellitus
title_short Ultrasonic predictors of macrosomia in gestational diabetes mellitus
title_full Ultrasonic predictors of macrosomia in gestational diabetes mellitus
title_fullStr Ultrasonic predictors of macrosomia in gestational diabetes mellitus
title_full_unstemmed Ultrasonic predictors of macrosomia in gestational diabetes mellitus
title_sort ultrasonic predictors of macrosomia in gestational diabetes mellitus
publisher Endocrinology Research Centre
publishDate 2019
url https://doaj.org/article/b0478a24092941008369ed5de1b04b8f
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