GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

Levels of sodium and potassium in urine are associated with cardiovascular traits. Here, Pazoki et al. perform genome-wide association studies for urinary sodium and potassium secretion and identify 50 and 13 novel loci, respectively, some of which show a potential causal relationship with blood pre...

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Autores principales: Raha Pazoki, Evangelos Evangelou, David Mosen-Ansorena, Rui Climaco Pinto, Ibrahim Karaman, Paul Blakeley, Dipender Gill, Verena Zuber, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b0491cd806ba41cd9e56d38859fd1475
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Sumario:Levels of sodium and potassium in urine are associated with cardiovascular traits. Here, Pazoki et al. perform genome-wide association studies for urinary sodium and potassium secretion and identify 50 and 13 novel loci, respectively, some of which show a potential causal relationship with blood pressure based on MR analysis.