Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

The activity of immune cells can be regulated by the microbiome. Here, the authors show that the fatty acids pentanoate and butyrate—normally released by the microbiome—increase the anti-tumour activity of cytotoxic T lymphocytes and chimeric antigen receptor T cells through metabolic and epigenetic...

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Autores principales:	Maik Luu, Zeno Riester, Adrian Baldrich, Nicole Reichardt, Samantha Yuille, Alessandro Busetti, Matthias Klein, Anne Wempe, Hanna Leister, Hartmann Raifer, Felix Picard, Khalid Muhammad, Kim Ohl, Rossana Romero, Florence Fischer, Christian A. Bauer, Magdalena Huber, Thomas M. Gress, Matthias Lauth, Sophia Danhof, Tobias Bopp, Thomas Nerreter, Imke E. Mulder, Ulrich Steinhoff, Michael Hudecek, Alexander Visekruna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b049d4b46e18405fa995dd666bce268c
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spelling	oai:doaj.org-article:b049d4b46e18405fa995dd666bce268c2021-12-02T16:31:43ZMicrobial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer10.1038/s41467-021-24331-12041-1723https://doaj.org/article/b049d4b46e18405fa995dd666bce268c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24331-1https://doaj.org/toc/2041-1723The activity of immune cells can be regulated by the microbiome. Here, the authors show that the fatty acids pentanoate and butyrate—normally released by the microbiome—increase the anti-tumour activity of cytotoxic T lymphocytes and chimeric antigen receptor T cells through metabolic and epigenetic reprogramming.Maik LuuZeno RiesterAdrian BaldrichNicole ReichardtSamantha YuilleAlessandro BusettiMatthias KleinAnne WempeHanna LeisterHartmann RaiferFelix PicardKhalid MuhammadKim OhlRossana RomeroFlorence FischerChristian A. BauerMagdalena HuberThomas M. GressMatthias LauthSophia DanhofTobias BoppThomas NerreterImke E. MulderUlrich SteinhoffMichael HudecekAlexander VisekrunaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maik Luu Zeno Riester Adrian Baldrich Nicole Reichardt Samantha Yuille Alessandro Busetti Matthias Klein Anne Wempe Hanna Leister Hartmann Raifer Felix Picard Khalid Muhammad Kim Ohl Rossana Romero Florence Fischer Christian A. Bauer Magdalena Huber Thomas M. Gress Matthias Lauth Sophia Danhof Tobias Bopp Thomas Nerreter Imke E. Mulder Ulrich Steinhoff Michael Hudecek Alexander Visekruna Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
description	The activity of immune cells can be regulated by the microbiome. Here, the authors show that the fatty acids pentanoate and butyrate—normally released by the microbiome—increase the anti-tumour activity of cytotoxic T lymphocytes and chimeric antigen receptor T cells through metabolic and epigenetic reprogramming.
format	article
author	Maik Luu Zeno Riester Adrian Baldrich Nicole Reichardt Samantha Yuille Alessandro Busetti Matthias Klein Anne Wempe Hanna Leister Hartmann Raifer Felix Picard Khalid Muhammad Kim Ohl Rossana Romero Florence Fischer Christian A. Bauer Magdalena Huber Thomas M. Gress Matthias Lauth Sophia Danhof Tobias Bopp Thomas Nerreter Imke E. Mulder Ulrich Steinhoff Michael Hudecek Alexander Visekruna
author_facet	Maik Luu Zeno Riester Adrian Baldrich Nicole Reichardt Samantha Yuille Alessandro Busetti Matthias Klein Anne Wempe Hanna Leister Hartmann Raifer Felix Picard Khalid Muhammad Kim Ohl Rossana Romero Florence Fischer Christian A. Bauer Magdalena Huber Thomas M. Gress Matthias Lauth Sophia Danhof Tobias Bopp Thomas Nerreter Imke E. Mulder Ulrich Steinhoff Michael Hudecek Alexander Visekruna
author_sort	Maik Luu
title	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
title_short	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
title_full	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
title_fullStr	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
title_full_unstemmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
title_sort	microbial short-chain fatty acids modulate cd8+ t cell responses and improve adoptive immunotherapy for cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b049d4b46e18405fa995dd666bce268c
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Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

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