Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction

Background and Objectives: Varicocele is the abnormal dilation and twisting of the veins of the pampiniform network, the spermatic cord of the testis. This event is associated with increased oxidative stress and decreased antioxidant capacity. The consequence of varicocele is a reduction in the qual...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohammadreza Sadraie, Marziyeh Tavalaee, Mohammad Hosein Nasr-Esfahani, Mohsen Forouzanfar
Formato:	article
Lenguaje:	FA
Publicado:	Qom University of Medical Sciences 2021
Materias:	sperm parameters varicocele curcumin oxidative stress male fertility Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b04a38bc762f4065b7f2cd0a70bc8d24
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b04a38bc762f4065b7f2cd0a70bc8d24
record_format	dspace
spelling	oai:doaj.org-article:b04a38bc762f4065b7f2cd0a70bc8d242021-12-05T11:40:12ZEvaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction1735-77992008-1375https://doaj.org/article/b04a38bc762f4065b7f2cd0a70bc8d242021-07-01T00:00:00Zhttp://journal.muq.ac.ir/article-1-3110-en.htmlhttps://doaj.org/toc/1735-7799https://doaj.org/toc/2008-1375Background and Objectives: Varicocele is the abnormal dilation and twisting of the veins of the pampiniform network, the spermatic cord of the testis. This event is associated with increased oxidative stress and decreased antioxidant capacity. The consequence of varicocele is a reduction in the quality of sperm parameters and defects in spermatogenesis. Curcumin has been introduced as an antioxidant with multiple and modulating potentials in biological activities. This study investigates the effect of curcumin on sperm parameters and the histological status of testicular tissue in rats with varicocele. Methods: For this study, 50 male Wistar rats were examined in 5 different groups: control, sham, varicocele, varicocele treated with curcumin 50 mg/kg, and varicocele treated with curcumin 100 mg/kg. Varicocele was induced through partial occlusion of the left renal vein. Then, sperm parameters and histological status of testicular tissue were assessed and analyzed using ANOVA test after 2 months of curcumin administration in varicocele rats. Results: This study showed that varicocele led to a significant decrease in motility percentage (P= 0.007), sperm concentration (P= 0.036), and a significant increase in abnormal sperm morphology (P≥0.05) compared to the control group. Although administration of curcumin in varicocele rats with concentrations of 50 and 100 mg/kg led to an improvement in sperm parameters, only in varicocele rats received 100 mg/kg curcumin, the concentration (P= 0.032) and total sperm motility (P= 0.04) significantly improved compared to varicocele group. In addition, curcumin improved the tissue damage caused by varicocele and increased the spermatogenesis index. Conclusion: The present study showed that curcumin improves the low quality of sperm parameters and can be a treatment strategy for future male infertility.Mohammadreza SadraieMarziyeh TavalaeeMohammad Hosein Nasr-EsfahaniMohsen ForouzanfarQom University of Medical Sciencesarticlesperm parametersvaricocelecurcuminoxidative stressmale fertilityMedicine (General)R5-920FAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 15, Iss 4, Pp 284-295 (2021)
institution	DOAJ
collection	DOAJ
language	FA
topic	sperm parameters varicocele curcumin oxidative stress male fertility Medicine (General) R5-920
spellingShingle	sperm parameters varicocele curcumin oxidative stress male fertility Medicine (General) R5-920 Mohammadreza Sadraie Marziyeh Tavalaee Mohammad Hosein Nasr-Esfahani Mohsen Forouzanfar Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction
description	Background and Objectives: Varicocele is the abnormal dilation and twisting of the veins of the pampiniform network, the spermatic cord of the testis. This event is associated with increased oxidative stress and decreased antioxidant capacity. The consequence of varicocele is a reduction in the quality of sperm parameters and defects in spermatogenesis. Curcumin has been introduced as an antioxidant with multiple and modulating potentials in biological activities. This study investigates the effect of curcumin on sperm parameters and the histological status of testicular tissue in rats with varicocele. Methods: For this study, 50 male Wistar rats were examined in 5 different groups: control, sham, varicocele, varicocele treated with curcumin 50 mg/kg, and varicocele treated with curcumin 100 mg/kg. Varicocele was induced through partial occlusion of the left renal vein. Then, sperm parameters and histological status of testicular tissue were assessed and analyzed using ANOVA test after 2 months of curcumin administration in varicocele rats. Results: This study showed that varicocele led to a significant decrease in motility percentage (P= 0.007), sperm concentration (P= 0.036), and a significant increase in abnormal sperm morphology (P≥0.05) compared to the control group. Although administration of curcumin in varicocele rats with concentrations of 50 and 100 mg/kg led to an improvement in sperm parameters, only in varicocele rats received 100 mg/kg curcumin, the concentration (P= 0.032) and total sperm motility (P= 0.04) significantly improved compared to varicocele group. In addition, curcumin improved the tissue damage caused by varicocele and increased the spermatogenesis index. Conclusion: The present study showed that curcumin improves the low quality of sperm parameters and can be a treatment strategy for future male infertility.
format	article
author	Mohammadreza Sadraie Marziyeh Tavalaee Mohammad Hosein Nasr-Esfahani Mohsen Forouzanfar
author_facet	Mohammadreza Sadraie Marziyeh Tavalaee Mohammad Hosein Nasr-Esfahani Mohsen Forouzanfar
author_sort	Mohammadreza Sadraie
title	Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction
title_short	Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction
title_full	Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction
title_fullStr	Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction
title_full_unstemmed	Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction
title_sort	evaluation of sperm and morphometric parameters of testicular tissue following curcumin administration in rats after varicocele induction
publisher	Qom University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/b04a38bc762f4065b7f2cd0a70bc8d24
work_keys_str_mv	AT mohammadrezasadraie evaluationofspermandmorphometricparametersoftesticulartissuefollowingcurcuminadministrationinratsaftervaricoceleinduction AT marziyehtavalaee evaluationofspermandmorphometricparametersoftesticulartissuefollowingcurcuminadministrationinratsaftervaricoceleinduction AT mohammadhoseinnasresfahani evaluationofspermandmorphometricparametersoftesticulartissuefollowingcurcuminadministrationinratsaftervaricoceleinduction AT mohsenforouzanfar evaluationofspermandmorphometricparametersoftesticulartissuefollowingcurcuminadministrationinratsaftervaricoceleinduction
_version_	1718372339540819968

Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction

Ejemplares similares