Brain fMRI during orientation selective epidural spinal cord stimulation

Abstract Epidural spinal cord stimulation (ESCS) is widely used for chronic pain treatment, and is also a promising tool for restoring motor function after spinal cord injury. Despite significant positive impact of ESCS, currently available protocols provide limited specificity and efficiency partia...

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Autores principales:	Antonietta Canna, Lauri J. Lehto, Lin Wu, Sheng Sang, Hanne Laakso, Jun Ma, Pavel Filip, Yuan Zhang, Olli Gröhn, Fabrizio Esposito, Clark C. Chen, Igor Lavrov, Shalom Michaeli, Silvia Mangia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b04de9cae18847f2a2d23a54939206e5
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spelling	oai:doaj.org-article:b04de9cae18847f2a2d23a54939206e52021-12-02T13:34:31ZBrain fMRI during orientation selective epidural spinal cord stimulation10.1038/s41598-021-84873-82045-2322https://doaj.org/article/b04de9cae18847f2a2d23a54939206e52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84873-8https://doaj.org/toc/2045-2322Abstract Epidural spinal cord stimulation (ESCS) is widely used for chronic pain treatment, and is also a promising tool for restoring motor function after spinal cord injury. Despite significant positive impact of ESCS, currently available protocols provide limited specificity and efficiency partially due to the limited number of contacts of the leads and to the limited flexibility to vary the spatial distribution of the stimulation field in respect to the spinal cord. Recently, we introduced Orientation Selective (OS) stimulation strategies for deep brain stimulation, and demonstrated their selectivity in rats using functional MRI (fMRI). The method achieves orientation selectivity by controlling the main direction of the electric field gradients using individually driven channels. Here, we introduced a similar OS approach for ESCS, and demonstrated orientation dependent brain activations as detected by brain fMRI. The fMRI activation patterns during spinal cord stimulation demonstrated the complexity of brain networks stimulated by OS-ESCS paradigms, involving brain areas responsible for the transmission of the motor and sensory information. The OS approach may allow targeting ESCS to spinal fibers of different orientations, ultimately making stimulation less dependent on the precision of the electrode implantation.Antonietta CannaLauri J. LehtoLin WuSheng SangHanne LaaksoJun MaPavel FilipYuan ZhangOlli GröhnFabrizio EspositoClark C. ChenIgor LavrovShalom MichaeliSilvia MangiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonietta Canna Lauri J. Lehto Lin Wu Sheng Sang Hanne Laakso Jun Ma Pavel Filip Yuan Zhang Olli Gröhn Fabrizio Esposito Clark C. Chen Igor Lavrov Shalom Michaeli Silvia Mangia Brain fMRI during orientation selective epidural spinal cord stimulation
description	Abstract Epidural spinal cord stimulation (ESCS) is widely used for chronic pain treatment, and is also a promising tool for restoring motor function after spinal cord injury. Despite significant positive impact of ESCS, currently available protocols provide limited specificity and efficiency partially due to the limited number of contacts of the leads and to the limited flexibility to vary the spatial distribution of the stimulation field in respect to the spinal cord. Recently, we introduced Orientation Selective (OS) stimulation strategies for deep brain stimulation, and demonstrated their selectivity in rats using functional MRI (fMRI). The method achieves orientation selectivity by controlling the main direction of the electric field gradients using individually driven channels. Here, we introduced a similar OS approach for ESCS, and demonstrated orientation dependent brain activations as detected by brain fMRI. The fMRI activation patterns during spinal cord stimulation demonstrated the complexity of brain networks stimulated by OS-ESCS paradigms, involving brain areas responsible for the transmission of the motor and sensory information. The OS approach may allow targeting ESCS to spinal fibers of different orientations, ultimately making stimulation less dependent on the precision of the electrode implantation.
format	article
author	Antonietta Canna Lauri J. Lehto Lin Wu Sheng Sang Hanne Laakso Jun Ma Pavel Filip Yuan Zhang Olli Gröhn Fabrizio Esposito Clark C. Chen Igor Lavrov Shalom Michaeli Silvia Mangia
author_facet	Antonietta Canna Lauri J. Lehto Lin Wu Sheng Sang Hanne Laakso Jun Ma Pavel Filip Yuan Zhang Olli Gröhn Fabrizio Esposito Clark C. Chen Igor Lavrov Shalom Michaeli Silvia Mangia
author_sort	Antonietta Canna
title	Brain fMRI during orientation selective epidural spinal cord stimulation
title_short	Brain fMRI during orientation selective epidural spinal cord stimulation
title_full	Brain fMRI during orientation selective epidural spinal cord stimulation
title_fullStr	Brain fMRI during orientation selective epidural spinal cord stimulation
title_full_unstemmed	Brain fMRI during orientation selective epidural spinal cord stimulation
title_sort	brain fmri during orientation selective epidural spinal cord stimulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b04de9cae18847f2a2d23a54939206e5
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Brain fMRI during orientation selective epidural spinal cord stimulation

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