Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy

Kinya Tsubota, Yoshihiko Usui, Yoshihiro Wakabayashi, Jun Suzuki, Shunichiro Ueda, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanPurpose: This study aimed to elucidate the effects of intravitreal bevacizumab (IVB) injections for the prevention of post-vitrec...

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Autores principales:	Tsubota K, Usui Y, Wakabayashi Y, Suzuki J, Ueda S, Goto H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Diabetic retinopathy VEGF vitreous hemorrhage intravitreal bevacizumab injection Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b05092cfe2164f4ca72a9bf47a968033
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spelling	oai:doaj.org-article:b05092cfe2164f4ca72a9bf47a9680332021-12-02T08:22:58ZEffectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy1177-5483https://doaj.org/article/b05092cfe2164f4ca72a9bf47a9680332019-06-01T00:00:00Zhttps://www.dovepress.com/effectiveness-of-prophylactic-intravitreal-bevacizumab-injection-to-pr-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kinya Tsubota, Yoshihiko Usui, Yoshihiro Wakabayashi, Jun Suzuki, Shunichiro Ueda, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanPurpose: This study aimed to elucidate the effects of intravitreal bevacizumab (IVB) injections for the prevention of post-vitrectomy complications in proliferative diabetic retinopathy (PDR) patients with elevated vitreous vascular endothelial growth factor (VEGF) concentration. Design: Prospective case series. Methods: Thirty-three patients (42 eyes) with PDR who underwent primary vitrectomy in the Department of Ophthalmology, Tokyo Medical University Hospital were studied. We measured VEGF concentrations in vitreous humor collected at the time of vitrectomy using ELISA. IVB injections were performed after vitrectomy in patients with vitreous VEGF levels exceeding 1,000 pg/mL. New bleeding occurring within 1 month of vitrectomy was defined as early vitreous hemorrhage (VH). Main outcome measure: The incidence of complications after vitrectomy including postoperative early VH. Results: IVB injections were administered to 11 eyes (26%) with vitreous VEGF concentrations exceeding 1,000 pg/mL. None of the 11 eyes that received an IVB injection developed early VH. Among 31 eyes (74%) with vitreous VEGF concentrations lower than 1,000 pg/mL, two eyes (6%) developed early VH after vitrectomy. Conclusions: Prophylactic IVB injections administered to patients with elevated preoperative intraocular VEGF concentrations were effective in preventing post-vitrectomy early VH.Keywords: diabetic retinopathy, VEGF, vitreous hemorrhage, intravitreal bevacizumab injectionTsubota KUsui YWakabayashi YSuzuki JUeda SGoto HDove Medical PressarticleDiabetic retinopathyVEGFvitreous hemorrhageintravitreal bevacizumab injection OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1063-1070 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetic retinopathy VEGF vitreous hemorrhage intravitreal bevacizumab injection Ophthalmology RE1-994
spellingShingle	Diabetic retinopathy VEGF vitreous hemorrhage intravitreal bevacizumab injection Ophthalmology RE1-994 Tsubota K Usui Y Wakabayashi Y Suzuki J Ueda S Goto H Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy
description	Kinya Tsubota, Yoshihiko Usui, Yoshihiro Wakabayashi, Jun Suzuki, Shunichiro Ueda, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanPurpose: This study aimed to elucidate the effects of intravitreal bevacizumab (IVB) injections for the prevention of post-vitrectomy complications in proliferative diabetic retinopathy (PDR) patients with elevated vitreous vascular endothelial growth factor (VEGF) concentration. Design: Prospective case series. Methods: Thirty-three patients (42 eyes) with PDR who underwent primary vitrectomy in the Department of Ophthalmology, Tokyo Medical University Hospital were studied. We measured VEGF concentrations in vitreous humor collected at the time of vitrectomy using ELISA. IVB injections were performed after vitrectomy in patients with vitreous VEGF levels exceeding 1,000 pg/mL. New bleeding occurring within 1 month of vitrectomy was defined as early vitreous hemorrhage (VH). Main outcome measure: The incidence of complications after vitrectomy including postoperative early VH. Results: IVB injections were administered to 11 eyes (26%) with vitreous VEGF concentrations exceeding 1,000 pg/mL. None of the 11 eyes that received an IVB injection developed early VH. Among 31 eyes (74%) with vitreous VEGF concentrations lower than 1,000 pg/mL, two eyes (6%) developed early VH after vitrectomy. Conclusions: Prophylactic IVB injections administered to patients with elevated preoperative intraocular VEGF concentrations were effective in preventing post-vitrectomy early VH.Keywords: diabetic retinopathy, VEGF, vitreous hemorrhage, intravitreal bevacizumab injection
format	article
author	Tsubota K Usui Y Wakabayashi Y Suzuki J Ueda S Goto H
author_facet	Tsubota K Usui Y Wakabayashi Y Suzuki J Ueda S Goto H
author_sort	Tsubota K
title	Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy
title_short	Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy
title_full	Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy
title_fullStr	Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy
title_full_unstemmed	Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy
title_sort	effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular vegf in preventing complications after vitrectomy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b05092cfe2164f4ca72a9bf47a968033
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Effectiveness of prophylactic intravitreal bevacizumab injection to proliferative diabetic retinopathy patients with elevated preoperative intraocular VEGF in preventing complications after vitrectomy

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