Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer

The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes responsible endocrine resistance in this region are unclear. In this study, the authors demonstrate that PRR11 located at 17q23, is critical for conferring endocrine resistance through activation of PI3K s...

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Autores principales:	Kyung-min Lee, Angel L. Guerrero-Zotano, Alberto Servetto, Dhivya R. Sudhan, Chang-Ching Lin, Luigi Formisano, Valerie M. Jansen, Paula González-Ericsson, Melinda E. Sanders, Thomas P. Stricker, Ganesh Raj, Kevin M. Dean, Reto Fiolka, Lewis C. Cantley, Ariella B. Hanker, Carlos L. Arteaga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b05239cf19fd4376936d7400b75ca161
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spelling	oai:doaj.org-article:b05239cf19fd4376936d7400b75ca1612021-12-02T14:41:14ZProline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer10.1038/s41467-020-19291-x2041-1723https://doaj.org/article/b05239cf19fd4376936d7400b75ca1612020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19291-xhttps://doaj.org/toc/2041-1723The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes responsible endocrine resistance in this region are unclear. In this study, the authors demonstrate that PRR11 located at 17q23, is critical for conferring endocrine resistance through activation of PI3K signalling and therefore propose PI3K inhibition as a treatment for PRR11-amplified breast cancers.Kyung-min LeeAngel L. Guerrero-ZotanoAlberto ServettoDhivya R. SudhanChang-Ching LinLuigi FormisanoValerie M. JansenPaula González-EricssonMelinda E. SandersThomas P. StrickerGanesh RajKevin M. DeanReto FiolkaLewis C. CantleyAriella B. HankerCarlos L. ArteagaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyung-min Lee Angel L. Guerrero-Zotano Alberto Servetto Dhivya R. Sudhan Chang-Ching Lin Luigi Formisano Valerie M. Jansen Paula González-Ericsson Melinda E. Sanders Thomas P. Stricker Ganesh Raj Kevin M. Dean Reto Fiolka Lewis C. Cantley Ariella B. Hanker Carlos L. Arteaga Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
description	The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes responsible endocrine resistance in this region are unclear. In this study, the authors demonstrate that PRR11 located at 17q23, is critical for conferring endocrine resistance through activation of PI3K signalling and therefore propose PI3K inhibition as a treatment for PRR11-amplified breast cancers.
format	article
author	Kyung-min Lee Angel L. Guerrero-Zotano Alberto Servetto Dhivya R. Sudhan Chang-Ching Lin Luigi Formisano Valerie M. Jansen Paula González-Ericsson Melinda E. Sanders Thomas P. Stricker Ganesh Raj Kevin M. Dean Reto Fiolka Lewis C. Cantley Ariella B. Hanker Carlos L. Arteaga
author_facet	Kyung-min Lee Angel L. Guerrero-Zotano Alberto Servetto Dhivya R. Sudhan Chang-Ching Lin Luigi Formisano Valerie M. Jansen Paula González-Ericsson Melinda E. Sanders Thomas P. Stricker Ganesh Raj Kevin M. Dean Reto Fiolka Lewis C. Cantley Ariella B. Hanker Carlos L. Arteaga
author_sort	Kyung-min Lee
title	Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
title_short	Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
title_full	Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
title_fullStr	Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
title_full_unstemmed	Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
title_sort	proline rich 11 (prr11) overexpression amplifies pi3k signaling and promotes antiestrogen resistance in breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b05239cf19fd4376936d7400b75ca161
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Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer

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