Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.

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Autores principales: Qiao Fan, Virginie J. M. Verhoeven, Robert Wojciechowski, Veluchamy A. Barathi, Pirro G. Hysi, Jeremy A. Guggenheim, René Höhn, Veronique Vitart, Anthony P. Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimäki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini, Masahiro Miyake, Alex W. Hewitt, Xiaobo Guo, Johanna Mazur, Jenifer E. Huffman, Katie M. Williams, Ozren Polasek, Harry Campbell, Igor Rudan, Zoran Vatavuk, James F. Wilson, Peter K. Joshi, George McMahon, Beate St Pourcain, David M. Evans, Claire L. Simpson, Tae-Hwi Schwantes-An, Robert P. Igo, Alireza Mirshahi, Audrey Cougnard-Gregoire, Céline Bellenguez, Maria Blettner, Olli Raitakari, Mika Kähönen, Ilkka Seppälä, Tanja Zeller, Thomas Meitinger, Janina S. Ried, Christian Gieger, Laura Portas, Elisabeth M. van Leeuwen, Najaf Amin, André G. Uitterlinden, Fernando Rivadeneira, Albert Hofman, Johannes R. Vingerling, Ya Xing Wang, Xu Wang, Eileen Tai-Hui Boh, M. Kamran Ikram, Charumathi Sabanayagam, Preeti Gupta, Vincent Tan, Lei Zhou, Candice E. H. Ho, Wan’e Lim, Roger W. Beuerman, Rosalynn Siantar, E-Shyong Tai, Eranga Vithana, Evelin Mihailov, Chiea-Chuen Khor, Caroline Hayward, Robert N. Luben, Paul J. Foster, Barbara E. K. Klein, Ronald Klein, Hoi-Suen Wong, Paul Mitchell, Andres Metspalu, Tin Aung, Terri L. Young, Mingguang He, Olavi Pärssinen, Cornelia M. van Duijn, Jie Jin Wang, Cathy Williams, Jost B. Jonas, Yik-Ying Teo, David A. Mackey, Konrad Oexle, Nagahisa Yoshimura, Andrew D. Paterson, Norbert Pfeiffer, Tien-Yin Wong, Paul N. Baird, Dwight Stambolian, Joan E. Bailey Wilson, Ching-Yu Cheng, Christopher J. Hammond, Caroline C. W. Klaver, Seang-Mei Saw, Consortium for Refractive Error and Myopia (CREAM)
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spelling oai:doaj.org-article:b0563139c510416e9a4da61510e1f5d42021-12-02T16:49:24ZMeta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error10.1038/ncomms110082041-1723https://doaj.org/article/b0563139c510416e9a4da61510e1f5d42016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11008https://doaj.org/toc/2041-1723This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.Qiao FanVirginie J. M. VerhoevenRobert WojciechowskiVeluchamy A. BarathiPirro G. HysiJeremy A. GuggenheimRené HöhnVeronique VitartAnthony P. KhawajaKenji YamashiroS Mohsen HosseiniTerho LehtimäkiYi LuToomas HallerJing XieCécile DelcourtMario PirastuJuho WedenojaPuya GharahkhaniCristina VenturiniMasahiro MiyakeAlex W. HewittXiaobo GuoJohanna MazurJenifer E. HuffmanKatie M. WilliamsOzren PolasekHarry CampbellIgor RudanZoran VatavukJames F. WilsonPeter K. JoshiGeorge McMahonBeate St PourcainDavid M. EvansClaire L. SimpsonTae-Hwi Schwantes-AnRobert P. IgoAlireza MirshahiAudrey Cougnard-GregoireCéline BellenguezMaria BlettnerOlli RaitakariMika KähönenIlkka SeppäläTanja ZellerThomas MeitingerJanina S. RiedChristian GiegerLaura PortasElisabeth M. van LeeuwenNajaf AminAndré G. UitterlindenFernando RivadeneiraAlbert HofmanJohannes R. VingerlingYa Xing WangXu WangEileen Tai-Hui BohM. Kamran IkramCharumathi SabanayagamPreeti GuptaVincent TanLei ZhouCandice E. H. HoWan’e LimRoger W. BeuermanRosalynn SiantarE-Shyong TaiEranga VithanaEvelin MihailovChiea-Chuen KhorCaroline HaywardRobert N. LubenPaul J. FosterBarbara E. K. KleinRonald KleinHoi-Suen WongPaul MitchellAndres MetspaluTin AungTerri L. YoungMingguang HeOlavi PärssinenCornelia M. van DuijnJie Jin WangCathy WilliamsJost B. JonasYik-Ying TeoDavid A. MackeyKonrad OexleNagahisa YoshimuraAndrew D. PatersonNorbert PfeifferTien-Yin WongPaul N. BairdDwight StambolianJoan E. Bailey WilsonChing-Yu ChengChristopher J. HammondCaroline C. W. KlaverSeang-Mei SawConsortium for Refractive Error and Myopia (CREAM)Nature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qiao Fan
Virginie J. M. Verhoeven
Robert Wojciechowski
Veluchamy A. Barathi
Pirro G. Hysi
Jeremy A. Guggenheim
René Höhn
Veronique Vitart
Anthony P. Khawaja
Kenji Yamashiro
S Mohsen Hosseini
Terho Lehtimäki
Yi Lu
Toomas Haller
Jing Xie
Cécile Delcourt
Mario Pirastu
Juho Wedenoja
Puya Gharahkhani
Cristina Venturini
Masahiro Miyake
Alex W. Hewitt
Xiaobo Guo
Johanna Mazur
Jenifer E. Huffman
Katie M. Williams
Ozren Polasek
Harry Campbell
Igor Rudan
Zoran Vatavuk
James F. Wilson
Peter K. Joshi
George McMahon
Beate St Pourcain
David M. Evans
Claire L. Simpson
Tae-Hwi Schwantes-An
Robert P. Igo
Alireza Mirshahi
Audrey Cougnard-Gregoire
Céline Bellenguez
Maria Blettner
Olli Raitakari
Mika Kähönen
Ilkka Seppälä
Tanja Zeller
Thomas Meitinger
Janina S. Ried
Christian Gieger
Laura Portas
Elisabeth M. van Leeuwen
Najaf Amin
André G. Uitterlinden
Fernando Rivadeneira
Albert Hofman
Johannes R. Vingerling
Ya Xing Wang
Xu Wang
Eileen Tai-Hui Boh
M. Kamran Ikram
Charumathi Sabanayagam
Preeti Gupta
Vincent Tan
Lei Zhou
Candice E. H. Ho
Wan’e Lim
Roger W. Beuerman
Rosalynn Siantar
E-Shyong Tai
Eranga Vithana
Evelin Mihailov
Chiea-Chuen Khor
Caroline Hayward
Robert N. Luben
Paul J. Foster
Barbara E. K. Klein
Ronald Klein
Hoi-Suen Wong
Paul Mitchell
Andres Metspalu
Tin Aung
Terri L. Young
Mingguang He
Olavi Pärssinen
Cornelia M. van Duijn
Jie Jin Wang
Cathy Williams
Jost B. Jonas
Yik-Ying Teo
David A. Mackey
Konrad Oexle
Nagahisa Yoshimura
Andrew D. Paterson
Norbert Pfeiffer
Tien-Yin Wong
Paul N. Baird
Dwight Stambolian
Joan E. Bailey Wilson
Ching-Yu Cheng
Christopher J. Hammond
Caroline C. W. Klaver
Seang-Mei Saw
Consortium for Refractive Error and Myopia (CREAM)
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
description This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.
format article
author Qiao Fan
Virginie J. M. Verhoeven
Robert Wojciechowski
Veluchamy A. Barathi
Pirro G. Hysi
Jeremy A. Guggenheim
René Höhn
Veronique Vitart
Anthony P. Khawaja
Kenji Yamashiro
S Mohsen Hosseini
Terho Lehtimäki
Yi Lu
Toomas Haller
Jing Xie
Cécile Delcourt
Mario Pirastu
Juho Wedenoja
Puya Gharahkhani
Cristina Venturini
Masahiro Miyake
Alex W. Hewitt
Xiaobo Guo
Johanna Mazur
Jenifer E. Huffman
Katie M. Williams
Ozren Polasek
Harry Campbell
Igor Rudan
Zoran Vatavuk
James F. Wilson
Peter K. Joshi
George McMahon
Beate St Pourcain
David M. Evans
Claire L. Simpson
Tae-Hwi Schwantes-An
Robert P. Igo
Alireza Mirshahi
Audrey Cougnard-Gregoire
Céline Bellenguez
Maria Blettner
Olli Raitakari
Mika Kähönen
Ilkka Seppälä
Tanja Zeller
Thomas Meitinger
Janina S. Ried
Christian Gieger
Laura Portas
Elisabeth M. van Leeuwen
Najaf Amin
André G. Uitterlinden
Fernando Rivadeneira
Albert Hofman
Johannes R. Vingerling
Ya Xing Wang
Xu Wang
Eileen Tai-Hui Boh
M. Kamran Ikram
Charumathi Sabanayagam
Preeti Gupta
Vincent Tan
Lei Zhou
Candice E. H. Ho
Wan’e Lim
Roger W. Beuerman
Rosalynn Siantar
E-Shyong Tai
Eranga Vithana
Evelin Mihailov
Chiea-Chuen Khor
Caroline Hayward
Robert N. Luben
Paul J. Foster
Barbara E. K. Klein
Ronald Klein
Hoi-Suen Wong
Paul Mitchell
Andres Metspalu
Tin Aung
Terri L. Young
Mingguang He
Olavi Pärssinen
Cornelia M. van Duijn
Jie Jin Wang
Cathy Williams
Jost B. Jonas
Yik-Ying Teo
David A. Mackey
Konrad Oexle
Nagahisa Yoshimura
Andrew D. Paterson
Norbert Pfeiffer
Tien-Yin Wong
Paul N. Baird
Dwight Stambolian
Joan E. Bailey Wilson
Ching-Yu Cheng
Christopher J. Hammond
Caroline C. W. Klaver
Seang-Mei Saw
Consortium for Refractive Error and Myopia (CREAM)
author_facet Qiao Fan
Virginie J. M. Verhoeven
Robert Wojciechowski
Veluchamy A. Barathi
Pirro G. Hysi
Jeremy A. Guggenheim
René Höhn
Veronique Vitart
Anthony P. Khawaja
Kenji Yamashiro
S Mohsen Hosseini
Terho Lehtimäki
Yi Lu
Toomas Haller
Jing Xie
Cécile Delcourt
Mario Pirastu
Juho Wedenoja
Puya Gharahkhani
Cristina Venturini
Masahiro Miyake
Alex W. Hewitt
Xiaobo Guo
Johanna Mazur
Jenifer E. Huffman
Katie M. Williams
Ozren Polasek
Harry Campbell
Igor Rudan
Zoran Vatavuk
James F. Wilson
Peter K. Joshi
George McMahon
Beate St Pourcain
David M. Evans
Claire L. Simpson
Tae-Hwi Schwantes-An
Robert P. Igo
Alireza Mirshahi
Audrey Cougnard-Gregoire
Céline Bellenguez
Maria Blettner
Olli Raitakari
Mika Kähönen
Ilkka Seppälä
Tanja Zeller
Thomas Meitinger
Janina S. Ried
Christian Gieger
Laura Portas
Elisabeth M. van Leeuwen
Najaf Amin
André G. Uitterlinden
Fernando Rivadeneira
Albert Hofman
Johannes R. Vingerling
Ya Xing Wang
Xu Wang
Eileen Tai-Hui Boh
M. Kamran Ikram
Charumathi Sabanayagam
Preeti Gupta
Vincent Tan
Lei Zhou
Candice E. H. Ho
Wan’e Lim
Roger W. Beuerman
Rosalynn Siantar
E-Shyong Tai
Eranga Vithana
Evelin Mihailov
Chiea-Chuen Khor
Caroline Hayward
Robert N. Luben
Paul J. Foster
Barbara E. K. Klein
Ronald Klein
Hoi-Suen Wong
Paul Mitchell
Andres Metspalu
Tin Aung
Terri L. Young
Mingguang He
Olavi Pärssinen
Cornelia M. van Duijn
Jie Jin Wang
Cathy Williams
Jost B. Jonas
Yik-Ying Teo
David A. Mackey
Konrad Oexle
Nagahisa Yoshimura
Andrew D. Paterson
Norbert Pfeiffer
Tien-Yin Wong
Paul N. Baird
Dwight Stambolian
Joan E. Bailey Wilson
Ching-Yu Cheng
Christopher J. Hammond
Caroline C. W. Klaver
Seang-Mei Saw
Consortium for Refractive Error and Myopia (CREAM)
author_sort Qiao Fan
title Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
title_short Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
title_full Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
title_fullStr Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
title_full_unstemmed Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
title_sort meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/b0563139c510416e9a4da61510e1f5d4
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