Targeting TBK1 Attenuates LPS-Induced NLRP3 Inflammasome Activation by Regulating of mTORC1 Pathways in Trophoblasts

Pathological maternal inflammation and abnormal placentation contribute to several pregnancy-related disorders, including preterm birth, intrauterine growth restriction, and preeclampsia. TANK-binding kinase 1 (TBK1), a serine/threonine kinase, has been implicated in the regulation of various physio...

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Bibliographic Details
Main Authors: Sohee Lee, Jiha Shin, Jong-Seok Kim, Jongdae Shin, Sung Ki Lee, Hwan-Woo Park
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
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Online Access:https://doaj.org/article/b05804b2a6a74dd6a1c36fa320f25701
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