Structure of the intact ATM/Tel1 kinase
The ataxia-telangiectasia mutated (ATM) protein kinase is a key player in the response to DNA damage and is essential for the maintenance of cellular homeostasis. Here the authors describe the cryo-EM structure of ATM/Tel1 from fission yeast that suggests how dimerization regulates its activity.
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Nature Portfolio
2016
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oai:doaj.org-article:b05ad494b9c64dc29b590d14a6ab737e2021-12-02T17:33:20ZStructure of the intact ATM/Tel1 kinase10.1038/ncomms116552041-1723https://doaj.org/article/b05ad494b9c64dc29b590d14a6ab737e2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11655https://doaj.org/toc/2041-1723The ataxia-telangiectasia mutated (ATM) protein kinase is a key player in the response to DNA damage and is essential for the maintenance of cellular homeostasis. Here the authors describe the cryo-EM structure of ATM/Tel1 from fission yeast that suggests how dimerization regulates its activity.Xuejuan WangHuanyu ChuMengjuan LvZhihui ZhangShuwan QiuHaiyan LiuXuetong ShenWeiwu WangGang CaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xuejuan Wang Huanyu Chu Mengjuan Lv Zhihui Zhang Shuwan Qiu Haiyan Liu Xuetong Shen Weiwu Wang Gang Cai Structure of the intact ATM/Tel1 kinase |
| description |
The ataxia-telangiectasia mutated (ATM) protein kinase is a key player in the response to DNA damage and is essential for the maintenance of cellular homeostasis. Here the authors describe the cryo-EM structure of ATM/Tel1 from fission yeast that suggests how dimerization regulates its activity. |
| format |
article |
| author |
Xuejuan Wang Huanyu Chu Mengjuan Lv Zhihui Zhang Shuwan Qiu Haiyan Liu Xuetong Shen Weiwu Wang Gang Cai |
| author_facet |
Xuejuan Wang Huanyu Chu Mengjuan Lv Zhihui Zhang Shuwan Qiu Haiyan Liu Xuetong Shen Weiwu Wang Gang Cai |
| author_sort |
Xuejuan Wang |
| title |
Structure of the intact ATM/Tel1 kinase |
| title_short |
Structure of the intact ATM/Tel1 kinase |
| title_full |
Structure of the intact ATM/Tel1 kinase |
| title_fullStr |
Structure of the intact ATM/Tel1 kinase |
| title_full_unstemmed |
Structure of the intact ATM/Tel1 kinase |
| title_sort |
structure of the intact atm/tel1 kinase |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/b05ad494b9c64dc29b590d14a6ab737e |
| work_keys_str_mv |
AT xuejuanwang structureoftheintactatmtel1kinase AT huanyuchu structureoftheintactatmtel1kinase AT mengjuanlv structureoftheintactatmtel1kinase AT zhihuizhang structureoftheintactatmtel1kinase AT shuwanqiu structureoftheintactatmtel1kinase AT haiyanliu structureoftheintactatmtel1kinase AT xuetongshen structureoftheintactatmtel1kinase AT weiwuwang structureoftheintactatmtel1kinase AT gangcai structureoftheintactatmtel1kinase |
| _version_ |
1718380020140867584 |