Structure of the intact ATM/Tel1 kinase

Structure of the intact ATM/Tel1 kinase

The ataxia-telangiectasia mutated (ATM) protein kinase is a key player in the response to DNA damage and is essential for the maintenance of cellular homeostasis. Here the authors describe the cryo-EM structure of ATM/Tel1 from fission yeast that suggests how dimerization regulates its activity.

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Autores principales: Xuejuan Wang, Huanyu Chu, Mengjuan Lv, Zhihui Zhang, Shuwan Qiu, Haiyan Liu, Xuetong Shen, Weiwu Wang, Gang Cai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/b05ad494b9c64dc29b590d14a6ab737e
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