Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice

Atherosclerosis and related cardiovascular diseases represent the greatest threats to human health, worldwide. Previous animal studies showed that selenium nanoparticles (SeNPs) and Na<sub>2</sub>SeO<sub>3</sub> might have anti-atherosclerotic activity, but the underlying mec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Junying Xiao, Na Li, Shengze Xiao, Yuzhou Wu, Hongmei Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sodium selenite selenium nanoparticles atherosclerosis inflammation endothelial dysfunction Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b05af31ca39b43b096f8f2e15e31b0b8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b05af31ca39b43b096f8f2e15e31b0b8
record_format	dspace
spelling	oai:doaj.org-article:b05af31ca39b43b096f8f2e15e31b0b82021-11-11T17:05:19ZComparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice10.3390/ijms2221116121422-00671661-6596https://doaj.org/article/b05af31ca39b43b096f8f2e15e31b0b82021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11612https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Atherosclerosis and related cardiovascular diseases represent the greatest threats to human health, worldwide. Previous animal studies showed that selenium nanoparticles (SeNPs) and Na<sub>2</sub>SeO<sub>3</sub> might have anti-atherosclerotic activity, but the underlying mechanisms are poorly elucidated. This study compared the anti-atherosclerotic activity of SeNPs stabilized with chitosan (CS-SeNPs) and Na<sub>2</sub>SeO<sub>3</sub> and the related mechanism in a high-fat-diet-fed apolipoprotein E-deficient mouse model of atherosclerosis. The results showed that oral administration of both CS-SeNPs and Na<sub>2</sub>SeO<sub>3</sub> (40 μg Se/kg/day) for 10 weeks significantly reduced atherosclerotic lesions in mouse aortae. Mechanistically, CS-SeNPs and Na<sub>2</sub>SeO<sub>3</sub> not only alleviated vascular endothelial dysfunction, as evidenced by the increase of serum nitric oxide level and the decrease of aortic adhesion molecule expression, but also vascular inflammation, as evidenced by the decrease of macrophage recruitment as well as the expression of proinflammatory molecules. Importantly, these results were replicated within in-vivo experiments on the cultured human endothelial cell line EA.hy926. Overall, CS-SeNPs had a comparable effect with Na<sub>2</sub>SeO<sub>3</sub> but might have more potential in atherosclerosis prevention due to its lower toxicity. Together, these results provide more insights into the mechanisms of selenium against atherosclerosis and further highlight the potential of selenium supplementation as a therapeutic strategy for atherosclerosis.Junying XiaoNa LiShengze XiaoYuzhou WuHongmei LiuMDPI AGarticlesodium seleniteselenium nanoparticlesatherosclerosisinflammationendothelial dysfunctionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11612, p 11612 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sodium selenite selenium nanoparticles atherosclerosis inflammation endothelial dysfunction Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	sodium selenite selenium nanoparticles atherosclerosis inflammation endothelial dysfunction Biology (General) QH301-705.5 Chemistry QD1-999 Junying Xiao Na Li Shengze Xiao Yuzhou Wu Hongmei Liu Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice
description	Atherosclerosis and related cardiovascular diseases represent the greatest threats to human health, worldwide. Previous animal studies showed that selenium nanoparticles (SeNPs) and Na<sub>2</sub>SeO<sub>3</sub> might have anti-atherosclerotic activity, but the underlying mechanisms are poorly elucidated. This study compared the anti-atherosclerotic activity of SeNPs stabilized with chitosan (CS-SeNPs) and Na<sub>2</sub>SeO<sub>3</sub> and the related mechanism in a high-fat-diet-fed apolipoprotein E-deficient mouse model of atherosclerosis. The results showed that oral administration of both CS-SeNPs and Na<sub>2</sub>SeO<sub>3</sub> (40 μg Se/kg/day) for 10 weeks significantly reduced atherosclerotic lesions in mouse aortae. Mechanistically, CS-SeNPs and Na<sub>2</sub>SeO<sub>3</sub> not only alleviated vascular endothelial dysfunction, as evidenced by the increase of serum nitric oxide level and the decrease of aortic adhesion molecule expression, but also vascular inflammation, as evidenced by the decrease of macrophage recruitment as well as the expression of proinflammatory molecules. Importantly, these results were replicated within in-vivo experiments on the cultured human endothelial cell line EA.hy926. Overall, CS-SeNPs had a comparable effect with Na<sub>2</sub>SeO<sub>3</sub> but might have more potential in atherosclerosis prevention due to its lower toxicity. Together, these results provide more insights into the mechanisms of selenium against atherosclerosis and further highlight the potential of selenium supplementation as a therapeutic strategy for atherosclerosis.
format	article
author	Junying Xiao Na Li Shengze Xiao Yuzhou Wu Hongmei Liu
author_facet	Junying Xiao Na Li Shengze Xiao Yuzhou Wu Hongmei Liu
author_sort	Junying Xiao
title	Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice
title_short	Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice
title_full	Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice
title_fullStr	Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice
title_full_unstemmed	Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice
title_sort	comparison of selenium nanoparticles and sodium selenite on the alleviation of early atherosclerosis by inhibiting endothelial dysfunction and inflammation in apolipoprotein e-deficient mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b05af31ca39b43b096f8f2e15e31b0b8
work_keys_str_mv	AT junyingxiao comparisonofseleniumnanoparticlesandsodiumseleniteonthealleviationofearlyatherosclerosisbyinhibitingendothelialdysfunctionandinflammationinapolipoproteinedeficientmice AT nali comparisonofseleniumnanoparticlesandsodiumseleniteonthealleviationofearlyatherosclerosisbyinhibitingendothelialdysfunctionandinflammationinapolipoproteinedeficientmice AT shengzexiao comparisonofseleniumnanoparticlesandsodiumseleniteonthealleviationofearlyatherosclerosisbyinhibitingendothelialdysfunctionandinflammationinapolipoproteinedeficientmice AT yuzhouwu comparisonofseleniumnanoparticlesandsodiumseleniteonthealleviationofearlyatherosclerosisbyinhibitingendothelialdysfunctionandinflammationinapolipoproteinedeficientmice AT hongmeiliu comparisonofseleniumnanoparticlesandsodiumseleniteonthealleviationofearlyatherosclerosisbyinhibitingendothelialdysfunctionandinflammationinapolipoproteinedeficientmice
_version_	1718432197066620928

Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice

Ejemplares similares