Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-...

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Autores principales:	Kunihiko Nishino, Seiji Yamasaki, Ryosuke Nakashima, Martijn Zwama, Mitsuko Hayashi-Nishino
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	inhibitor regulation drug resistance Gram-negative bacteria multidrug efflux pumps Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b064dc085bba46ee95485b4c980c6ccb
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spelling	oai:doaj.org-article:b064dc085bba46ee95485b4c980c6ccb2021-12-03T07:17:17ZFunction and Inhibitory Mechanisms of Multidrug Efflux Pumps1664-302X10.3389/fmicb.2021.737288https://doaj.org/article/b064dc085bba46ee95485b4c980c6ccb2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.737288/fullhttps://doaj.org/toc/1664-302XMultidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-crystal structural analysis of multidrug efflux pumps revealed the drug recognition and export mechanisms, and the inhibitory mechanisms of the pumps. A single multidrug efflux pump can export multiple antibiotics; hence, developing efflux pump inhibitors is crucial in overcoming infectious diseases caused by multidrug-resistant bacteria. This review article describes the role of multidrug efflux pumps in MDR, and their physiological functions and inhibitory mechanisms.Kunihiko NishinoSeiji YamasakiRyosuke NakashimaMartijn ZwamaMitsuko Hayashi-NishinoFrontiers Media S.A.articleinhibitorregulationdrug resistanceGram-negative bacteriamultidrug efflux pumpsMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inhibitor regulation drug resistance Gram-negative bacteria multidrug efflux pumps Microbiology QR1-502
spellingShingle	inhibitor regulation drug resistance Gram-negative bacteria multidrug efflux pumps Microbiology QR1-502 Kunihiko Nishino Seiji Yamasaki Ryosuke Nakashima Martijn Zwama Mitsuko Hayashi-Nishino Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
description	Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-crystal structural analysis of multidrug efflux pumps revealed the drug recognition and export mechanisms, and the inhibitory mechanisms of the pumps. A single multidrug efflux pump can export multiple antibiotics; hence, developing efflux pump inhibitors is crucial in overcoming infectious diseases caused by multidrug-resistant bacteria. This review article describes the role of multidrug efflux pumps in MDR, and their physiological functions and inhibitory mechanisms.
format	article
author	Kunihiko Nishino Seiji Yamasaki Ryosuke Nakashima Martijn Zwama Mitsuko Hayashi-Nishino
author_facet	Kunihiko Nishino Seiji Yamasaki Ryosuke Nakashima Martijn Zwama Mitsuko Hayashi-Nishino
author_sort	Kunihiko Nishino
title	Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_short	Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_full	Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_fullStr	Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_full_unstemmed	Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_sort	function and inhibitory mechanisms of multidrug efflux pumps
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b064dc085bba46ee95485b4c980c6ccb
work_keys_str_mv	AT kunihikonishino functionandinhibitorymechanismsofmultidrugeffluxpumps AT seijiyamasaki functionandinhibitorymechanismsofmultidrugeffluxpumps AT ryosukenakashima functionandinhibitorymechanismsofmultidrugeffluxpumps AT martijnzwama functionandinhibitorymechanismsofmultidrugeffluxpumps AT mitsukohayashinishino functionandinhibitorymechanismsofmultidrugeffluxpumps
_version_	1718373831819657216

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

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