High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces

Abstract Almost half of dental restorations have failed in less than 10 years, and approximately 60% of practice time has been consumed to replace these dental restorations. As such, contemporary dentin adhesives should be modified to treat secondary caries and prevent the degradation of adhesive–de...

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Autores principales:	Hongye Yang, Kang Li, Huiyi Yan, Siying Liu, Yake Wang, Cui Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b067373c3d2f40659fee9f083a7dacac
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spelling	oai:doaj.org-article:b067373c3d2f40659fee9f083a7dacac2021-12-02T16:06:30ZHigh-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces10.1038/s41598-017-08633-32045-2322https://doaj.org/article/b067373c3d2f40659fee9f083a7dacac2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08633-3https://doaj.org/toc/2045-2322Abstract Almost half of dental restorations have failed in less than 10 years, and approximately 60% of practice time has been consumed to replace these dental restorations. As such, contemporary dentin adhesives should be modified to treat secondary caries and prevent the degradation of adhesive–dentin interfaces. To achieve this goal, we developed a versatile therapeutic adhesive in the present study by incorporating quercetin, which is a naturally derived plant extract, into a commercial adhesive at three concentrations (100, 500 and 1000 µg/mL). An unmodified adhesive served as a control. The antibacterial ability on Streptococcus mutans biofilm, conversion degree, microtensile bond strength, failure modes, in situ zymography, nanoleakage expression and cytotoxicity of quercetin-doped adhesive were comprehensively evaluated. Results showed that the quercetin-doped adhesive (500 µg/mL) preserved its bonding properties against collagenase ageing and inhibited the growth of S. mutans biofilm. Efficient bonding interface sealing ability, matrix metalloproteinase inhibition and acceptable biocompatibility were also achieved. Thus, a simple, safe and workable strategy was successfully developed to produce therapeutic adhesives for the extension of the service life of adhesive restorations.Hongye YangKang LiHuiyi YanSiying LiuYake WangCui HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongye Yang Kang Li Huiyi Yan Siying Liu Yake Wang Cui Huang High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces
description	Abstract Almost half of dental restorations have failed in less than 10 years, and approximately 60% of practice time has been consumed to replace these dental restorations. As such, contemporary dentin adhesives should be modified to treat secondary caries and prevent the degradation of adhesive–dentin interfaces. To achieve this goal, we developed a versatile therapeutic adhesive in the present study by incorporating quercetin, which is a naturally derived plant extract, into a commercial adhesive at three concentrations (100, 500 and 1000 µg/mL). An unmodified adhesive served as a control. The antibacterial ability on Streptococcus mutans biofilm, conversion degree, microtensile bond strength, failure modes, in situ zymography, nanoleakage expression and cytotoxicity of quercetin-doped adhesive were comprehensively evaluated. Results showed that the quercetin-doped adhesive (500 µg/mL) preserved its bonding properties against collagenase ageing and inhibited the growth of S. mutans biofilm. Efficient bonding interface sealing ability, matrix metalloproteinase inhibition and acceptable biocompatibility were also achieved. Thus, a simple, safe and workable strategy was successfully developed to produce therapeutic adhesives for the extension of the service life of adhesive restorations.
format	article
author	Hongye Yang Kang Li Huiyi Yan Siying Liu Yake Wang Cui Huang
author_facet	Hongye Yang Kang Li Huiyi Yan Siying Liu Yake Wang Cui Huang
author_sort	Hongye Yang
title	High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces
title_short	High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces
title_full	High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces
title_fullStr	High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces
title_full_unstemmed	High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces
title_sort	high-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b067373c3d2f40659fee9f083a7dacac
work_keys_str_mv	AT hongyeyang highperformancetherapeuticquercetindopedadhesiveforadhesivedentininterfaces AT kangli highperformancetherapeuticquercetindopedadhesiveforadhesivedentininterfaces AT huiyiyan highperformancetherapeuticquercetindopedadhesiveforadhesivedentininterfaces AT siyingliu highperformancetherapeuticquercetindopedadhesiveforadhesivedentininterfaces AT yakewang highperformancetherapeuticquercetindopedadhesiveforadhesivedentininterfaces AT cuihuang highperformancetherapeuticquercetindopedadhesiveforadhesivedentininterfaces
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High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces

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