The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model.
The impact of exogenic testosterone (T): 1.5 and 3.0 mg/kg.bw) and 19-nortestosterone 17-decanoate (ND): 1.5 and 7.5 mg/kg.bw) in castrated male rats was evaluated based on: (a) weight increase of the androgen target tissues, respecting the Hershberger methodology; (b) the 17α and β-testosterone, 17...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b06745ef560d447db994e751f19fea63 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b06745ef560d447db994e751f19fea63 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b06745ef560d447db994e751f19fea632021-11-25T05:57:11ZThe impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model.1932-620310.1371/journal.pone.0109219https://doaj.org/article/b06745ef560d447db994e751f19fea632014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109219https://doaj.org/toc/1932-6203The impact of exogenic testosterone (T): 1.5 and 3.0 mg/kg.bw) and 19-nortestosterone 17-decanoate (ND): 1.5 and 7.5 mg/kg.bw) in castrated male rats was evaluated based on: (a) weight increase of the androgen target tissues, respecting the Hershberger methodology; (b) the 17α and β-testosterone, 17 α and β-estradiol and 17 α and β-nortestosterone levels using the GC-MS/MS technique; and (c) observation of the serum free thyroxine levels (T4). Results revealed that T and ND significantly increased the weight of androgen target tissues as follows: ND was more influential on seminal vesicles, levator ani-bulbocavernosus muscle (LABC) and Cowper's glands and T (at a dose of 3.0 mg/kg.bw) influenced the weight of the ventral prostate and glans penis. Serum samples analyzed for steroid hormone levels showed the presence of 17β-testosterone, 17β-estradiol and 17β-nor-testosterone, in castrated male rats injected with testosterone and nortestosterone, but no significant differences were found between thyroid responses and thyroid hormone levels. The results of this research proved the disrupting activity of T and ND when administered in high doses and the useful application of the Hershberger bioassay in the case of ND.Romeo Teodor CristinaFlavia HanganuEugenia DumitrescuFlorin MuselinMonica ButnariuAdriana ConstantinViorica ChiurciuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109219 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Romeo Teodor Cristina Flavia Hanganu Eugenia Dumitrescu Florin Muselin Monica Butnariu Adriana Constantin Viorica Chiurciu The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model. |
| description |
The impact of exogenic testosterone (T): 1.5 and 3.0 mg/kg.bw) and 19-nortestosterone 17-decanoate (ND): 1.5 and 7.5 mg/kg.bw) in castrated male rats was evaluated based on: (a) weight increase of the androgen target tissues, respecting the Hershberger methodology; (b) the 17α and β-testosterone, 17 α and β-estradiol and 17 α and β-nortestosterone levels using the GC-MS/MS technique; and (c) observation of the serum free thyroxine levels (T4). Results revealed that T and ND significantly increased the weight of androgen target tissues as follows: ND was more influential on seminal vesicles, levator ani-bulbocavernosus muscle (LABC) and Cowper's glands and T (at a dose of 3.0 mg/kg.bw) influenced the weight of the ventral prostate and glans penis. Serum samples analyzed for steroid hormone levels showed the presence of 17β-testosterone, 17β-estradiol and 17β-nor-testosterone, in castrated male rats injected with testosterone and nortestosterone, but no significant differences were found between thyroid responses and thyroid hormone levels. The results of this research proved the disrupting activity of T and ND when administered in high doses and the useful application of the Hershberger bioassay in the case of ND. |
| format |
article |
| author |
Romeo Teodor Cristina Flavia Hanganu Eugenia Dumitrescu Florin Muselin Monica Butnariu Adriana Constantin Viorica Chiurciu |
| author_facet |
Romeo Teodor Cristina Flavia Hanganu Eugenia Dumitrescu Florin Muselin Monica Butnariu Adriana Constantin Viorica Chiurciu |
| author_sort |
Romeo Teodor Cristina |
| title |
The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model. |
| title_short |
The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model. |
| title_full |
The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model. |
| title_fullStr |
The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model. |
| title_full_unstemmed |
The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model. |
| title_sort |
impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/b06745ef560d447db994e751f19fea63 |
| work_keys_str_mv |
AT romeoteodorcristina theimpactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT flaviahanganu theimpactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT eugeniadumitrescu theimpactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT florinmuselin theimpactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT monicabutnariu theimpactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT adrianaconstantin theimpactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT vioricachiurciu theimpactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT romeoteodorcristina impactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT flaviahanganu impactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT eugeniadumitrescu impactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT florinmuselin impactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT monicabutnariu impactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT adrianaconstantin impactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel AT vioricachiurciu impactofexogenictestosteroneandnortestosteronedecanoatetoxicologicalevaluationusingaratmodel |
| _version_ |
1718414360675614720 |