The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice

Brain glycogen metabolism is known to be involved in the learning and memory processes. Protein targeting to glycogen (PTG) is a crucial molecule for glycogenesis, and its expression level is shown to be increased in the dorsal hippocampus during fear memory acquisition and recall, suggesting that P...

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Autores principales:	Yuki Kambe, Thu Nguyen Thi, Kohei Hashiguchi, Yoshimune Sameshima, Akira Yamashita, Takashi Kurihara, Atsuro Miyata
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Protein targeting to glycogen Working memory Short-term memory Astrocytes Ionotropic glutamate receptors Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b068303aa6024d33b50dc507fec86d08
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spelling	oai:doaj.org-article:b068303aa6024d33b50dc507fec86d082021-11-14T04:31:17ZThe dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice1347-861310.1016/j.jphs.2021.10.008https://doaj.org/article/b068303aa6024d33b50dc507fec86d082022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1347861321001031https://doaj.org/toc/1347-8613Brain glycogen metabolism is known to be involved in the learning and memory processes. Protein targeting to glycogen (PTG) is a crucial molecule for glycogenesis, and its expression level is shown to be increased in the dorsal hippocampus during fear memory acquisition and recall, suggesting that PTG may contribute to the memory process. However, its detailed role in the dorsal hippocampus remains unclear. Therefore, we knocked down the expression of PTG in the dorsal hippocampus and attempted to analyze its function behaviorally. PTG expression was found to be enriched in astrocytes. Furthermore, short hairpin RNA against PTG suppressed the expression of PTG in astrocytes. Mice with knockdown of PTG in the dorsal hippocampus showed suppressed alternation behavior in the Y-maze test and reduced memory recall at the first hour after acquisition in the passive avoidance test. Knockdown of mouse dorsal hippocampal astrocyte-specific PTG also impaired working memory in the Y-maze test. GluR1, GluR2, and NR2a subunits expressions were significantly down-regulated in the dorsal hippocampus of mice in which PTG was knocked down. These results indicate that PTG in the dorsal hippocampal astrocytes may contribute to working and short-term memories by maintaining the expression of glutamate receptor subunits.Yuki KambeThu Nguyen ThiKohei HashiguchiYoshimune SameshimaAkira YamashitaTakashi KuriharaAtsuro MiyataElsevierarticleProtein targeting to glycogenWorking memoryShort-term memoryAstrocytesIonotropic glutamate receptorsTherapeutics. PharmacologyRM1-950ENJournal of Pharmacological Sciences, Vol 148, Iss 1, Pp 108-115 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Protein targeting to glycogen Working memory Short-term memory Astrocytes Ionotropic glutamate receptors Therapeutics. Pharmacology RM1-950
spellingShingle	Protein targeting to glycogen Working memory Short-term memory Astrocytes Ionotropic glutamate receptors Therapeutics. Pharmacology RM1-950 Yuki Kambe Thu Nguyen Thi Kohei Hashiguchi Yoshimune Sameshima Akira Yamashita Takashi Kurihara Atsuro Miyata The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice
description	Brain glycogen metabolism is known to be involved in the learning and memory processes. Protein targeting to glycogen (PTG) is a crucial molecule for glycogenesis, and its expression level is shown to be increased in the dorsal hippocampus during fear memory acquisition and recall, suggesting that PTG may contribute to the memory process. However, its detailed role in the dorsal hippocampus remains unclear. Therefore, we knocked down the expression of PTG in the dorsal hippocampus and attempted to analyze its function behaviorally. PTG expression was found to be enriched in astrocytes. Furthermore, short hairpin RNA against PTG suppressed the expression of PTG in astrocytes. Mice with knockdown of PTG in the dorsal hippocampus showed suppressed alternation behavior in the Y-maze test and reduced memory recall at the first hour after acquisition in the passive avoidance test. Knockdown of mouse dorsal hippocampal astrocyte-specific PTG also impaired working memory in the Y-maze test. GluR1, GluR2, and NR2a subunits expressions were significantly down-regulated in the dorsal hippocampus of mice in which PTG was knocked down. These results indicate that PTG in the dorsal hippocampal astrocytes may contribute to working and short-term memories by maintaining the expression of glutamate receptor subunits.
format	article
author	Yuki Kambe Thu Nguyen Thi Kohei Hashiguchi Yoshimune Sameshima Akira Yamashita Takashi Kurihara Atsuro Miyata
author_facet	Yuki Kambe Thu Nguyen Thi Kohei Hashiguchi Yoshimune Sameshima Akira Yamashita Takashi Kurihara Atsuro Miyata
author_sort	Yuki Kambe
title	The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice
title_short	The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice
title_full	The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice
title_fullStr	The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice
title_full_unstemmed	The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice
title_sort	dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/b068303aa6024d33b50dc507fec86d08
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The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice

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