High prevalence of systemic autoimmune diseases in patients with Menière's disease.

<h4>Background</h4>Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD...

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Autores principales:	Irene Gazquez, Andres Soto-Varela, Ismael Aran, Sofia Santos, Angel Batuecas, Gabriel Trinidad, Herminio Perez-Garrigues, Carlos Gonzalez-Oller, Lourdes Acosta, Jose A Lopez-Escamez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b06a9a6ea68a4d56878deba16445c308
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spelling	oai:doaj.org-article:b06a9a6ea68a4d56878deba16445c3082021-11-18T07:35:25ZHigh prevalence of systemic autoimmune diseases in patients with Menière's disease.1932-620310.1371/journal.pone.0026759https://doaj.org/article/b06a9a6ea68a4d56878deba16445c3082011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22053211/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD has not been studied in individuals with uni or bilateral sensorineural hearing loss (SNHL).<h4>Methods and findings</h4>We estimated the prevalence of AD in 690 outpatients with MD with uni or bilateral SNHL from otoneurology clinics at six tertiary referral hospitals by using clinica criteria and an immune panel (lymphocyte populations, antinuclear antibodies, C3, C4 and proinflammatory cytokines TNFα, INFγ). The observed prevalence of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) was higher than expected for the general population (1.39 for RA, 0.87 for SLE and 0.70 for AS, respectively). Systemic AD were more frequently observed in patients with MD and diagnostic criteria for migraine than cases with MD and tension-type headache (p = 0.007). There were clinical differences between patients with uni or bilateral SNHL, but no differences were found in the immune profile. Multiple linear regression showed that changes in lymphocytes subpopulations were associated with hearing loss and persistence of vertigo, suggesting a role for the immune response in MD.<h4>Conclusions</h4>Despite some limitations, MD displays an elevated prevalence of systemic AD such as RA, SLE and AS. This finding, which suggests an autoimmune background in a subset of patients with MD, has important implications for the treatment of MD.Irene GazquezAndres Soto-VarelaIsmael AranSofia SantosAngel BatuecasGabriel TrinidadHerminio Perez-GarriguesCarlos Gonzalez-OllerLourdes AcostaJose A Lopez-EscamezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26759 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irene Gazquez Andres Soto-Varela Ismael Aran Sofia Santos Angel Batuecas Gabriel Trinidad Herminio Perez-Garrigues Carlos Gonzalez-Oller Lourdes Acosta Jose A Lopez-Escamez High prevalence of systemic autoimmune diseases in patients with Menière's disease.
description	<h4>Background</h4>Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD has not been studied in individuals with uni or bilateral sensorineural hearing loss (SNHL).<h4>Methods and findings</h4>We estimated the prevalence of AD in 690 outpatients with MD with uni or bilateral SNHL from otoneurology clinics at six tertiary referral hospitals by using clinica criteria and an immune panel (lymphocyte populations, antinuclear antibodies, C3, C4 and proinflammatory cytokines TNFα, INFγ). The observed prevalence of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) was higher than expected for the general population (1.39 for RA, 0.87 for SLE and 0.70 for AS, respectively). Systemic AD were more frequently observed in patients with MD and diagnostic criteria for migraine than cases with MD and tension-type headache (p = 0.007). There were clinical differences between patients with uni or bilateral SNHL, but no differences were found in the immune profile. Multiple linear regression showed that changes in lymphocytes subpopulations were associated with hearing loss and persistence of vertigo, suggesting a role for the immune response in MD.<h4>Conclusions</h4>Despite some limitations, MD displays an elevated prevalence of systemic AD such as RA, SLE and AS. This finding, which suggests an autoimmune background in a subset of patients with MD, has important implications for the treatment of MD.
format	article
author	Irene Gazquez Andres Soto-Varela Ismael Aran Sofia Santos Angel Batuecas Gabriel Trinidad Herminio Perez-Garrigues Carlos Gonzalez-Oller Lourdes Acosta Jose A Lopez-Escamez
author_facet	Irene Gazquez Andres Soto-Varela Ismael Aran Sofia Santos Angel Batuecas Gabriel Trinidad Herminio Perez-Garrigues Carlos Gonzalez-Oller Lourdes Acosta Jose A Lopez-Escamez
author_sort	Irene Gazquez
title	High prevalence of systemic autoimmune diseases in patients with Menière's disease.
title_short	High prevalence of systemic autoimmune diseases in patients with Menière's disease.
title_full	High prevalence of systemic autoimmune diseases in patients with Menière's disease.
title_fullStr	High prevalence of systemic autoimmune diseases in patients with Menière's disease.
title_full_unstemmed	High prevalence of systemic autoimmune diseases in patients with Menière's disease.
title_sort	high prevalence of systemic autoimmune diseases in patients with menière's disease.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/b06a9a6ea68a4d56878deba16445c308
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High prevalence of systemic autoimmune diseases in patients with Menière's disease.

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