The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2

There are reports on the effects of excessive recipient body weight on renal graft function. Increased CCL2 (chemokine CC-mortif ligand 2) production is observed in patients with excessive body weight. CCL2 also exacerbates the inflammatory process in the renal graft. A total of 49 renal graft recip...

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Autores principales:	Magdalena Nalewajska, Martyna Opara-Bajerowicz, Krzysztof Safranow, Andrzej Pawlik, Kazimierz Ciechanowski, Sebastian Kwiatkowski, Ewa Kwiatkowska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chemokines CCL2 kidney transplantation weight excess sex dimorphism Medicine R
Acceso en línea:	https://doaj.org/article/b06cef9368e14b4c977fa7b06f87861a
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spelling	oai:doaj.org-article:b06cef9368e14b4c977fa7b06f87861a2021-11-11T17:35:07ZThe Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL210.3390/jcm102149512077-0383https://doaj.org/article/b06cef9368e14b4c977fa7b06f87861a2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4951https://doaj.org/toc/2077-0383There are reports on the effects of excessive recipient body weight on renal graft function. Increased CCL2 (chemokine CC-mortif ligand 2) production is observed in patients with excessive body weight. CCL2 also exacerbates the inflammatory process in the renal graft. A total of 49 renal graft recipients of both sexes having undergone renal biopsy within the last 18 months were retrospectively reviewed. At their most recent appointment the patients’ plasma concentrations of CCL2 were evaluated. Renal function was assessed retrospectively. CCL2 concentrations were higher in men than women (<i>p</i> < 0.047), while higher CCL2 levels were associated with a decrease in eGFR (estimated glomerular filtration rate) during the first year post Tx (kidney transplantation). CCL2 negatively correlated with eGFR at 5 years (R = −0.45, <i>p</i> < 0.040997) and positively correlated with the degree of tubular atrophy in renal biopsy specimens (R = 0.43, <i>p</i> < 0.027293) and with systolic pressure. Men showed significantly higher BMI (body mass index) values at the time of Tx and at their last appointment than women did (<i>p</i> < 0.000403; <i>p</i> < 0.000613, respectively). Men showed poorer long-term renal graft function, with significantly lower eGFR values at 4 and 5 years into the post-transplantation period. The male sex and excessive body weight have adverse effects on short- and long-term renal graft function, which is associated with increased levels of CCL2.Magdalena NalewajskaMartyna Opara-BajerowiczKrzysztof SafranowAndrzej PawlikKazimierz CiechanowskiSebastian KwiatkowskiEwa KwiatkowskaMDPI AGarticlechemokinesCCL2kidney transplantationweight excesssex dimorphismMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4951, p 4951 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemokines CCL2 kidney transplantation weight excess sex dimorphism Medicine R
spellingShingle	chemokines CCL2 kidney transplantation weight excess sex dimorphism Medicine R Magdalena Nalewajska Martyna Opara-Bajerowicz Krzysztof Safranow Andrzej Pawlik Kazimierz Ciechanowski Sebastian Kwiatkowski Ewa Kwiatkowska The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2
description	There are reports on the effects of excessive recipient body weight on renal graft function. Increased CCL2 (chemokine CC-mortif ligand 2) production is observed in patients with excessive body weight. CCL2 also exacerbates the inflammatory process in the renal graft. A total of 49 renal graft recipients of both sexes having undergone renal biopsy within the last 18 months were retrospectively reviewed. At their most recent appointment the patients’ plasma concentrations of CCL2 were evaluated. Renal function was assessed retrospectively. CCL2 concentrations were higher in men than women (<i>p</i> < 0.047), while higher CCL2 levels were associated with a decrease in eGFR (estimated glomerular filtration rate) during the first year post Tx (kidney transplantation). CCL2 negatively correlated with eGFR at 5 years (R = −0.45, <i>p</i> < 0.040997) and positively correlated with the degree of tubular atrophy in renal biopsy specimens (R = 0.43, <i>p</i> < 0.027293) and with systolic pressure. Men showed significantly higher BMI (body mass index) values at the time of Tx and at their last appointment than women did (<i>p</i> < 0.000403; <i>p</i> < 0.000613, respectively). Men showed poorer long-term renal graft function, with significantly lower eGFR values at 4 and 5 years into the post-transplantation period. The male sex and excessive body weight have adverse effects on short- and long-term renal graft function, which is associated with increased levels of CCL2.
format	article
author	Magdalena Nalewajska Martyna Opara-Bajerowicz Krzysztof Safranow Andrzej Pawlik Kazimierz Ciechanowski Sebastian Kwiatkowski Ewa Kwiatkowska
author_facet	Magdalena Nalewajska Martyna Opara-Bajerowicz Krzysztof Safranow Andrzej Pawlik Kazimierz Ciechanowski Sebastian Kwiatkowski Ewa Kwiatkowska
author_sort	Magdalena Nalewajska
title	The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2
title_short	The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2
title_full	The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2
title_fullStr	The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2
title_full_unstemmed	The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2
title_sort	effects of sex and body weight on renal graft function—the role of ccl2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b06cef9368e14b4c977fa7b06f87861a
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The Effects of Sex and Body Weight on Renal Graft Function—The Role of CCL2

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