FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model

FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model

Abstract Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer’s disease. Molecular chaperones with peptidyl-prolyl cis/trans isomerase (PPIase) activity are known to regulate these processes. Previously, in vitro studies have shown that...

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Autores principales: Marangelie Criado-Marrero, Niat T. Gebru, Lauren A. Gould, Danielle M. Blazier, Yamile Vidal-Aguiar, Taylor M. Smith, Salma S. Abdelmaboud, Lindsey B. Shelton, Xinming Wang, Jan Dahrendorff, David Beaulieu-Abdelahad, Chad A. Dickey, Laura J. Blair
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/b06d2c045077424ca482d80168b5726e
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