Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease
Background. The prevalence of obesity in patients with stable coronary artery disease (CAD) and arterial hypertension (AH) is increasing each year. As the number of percutaneous coronary interventions requiring contrast media administration is rising in this group of patients, the risk of contrast-i...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
IP Morozov P.V.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b06e0fed01fa4ef6bbdcbfed80098a72 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b06e0fed01fa4ef6bbdcbfed80098a72 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b06e0fed01fa4ef6bbdcbfed80098a722021-11-30T16:09:16ZObesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease2075-082X2542-218910.26442/2075082X.2020.4.200546https://doaj.org/article/b06e0fed01fa4ef6bbdcbfed80098a722021-02-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/60287/43457https://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189Background. The prevalence of obesity in patients with stable coronary artery disease (CAD) and arterial hypertension (AH) is increasing each year. As the number of percutaneous coronary interventions requiring contrast media administration is rising in this group of patients, the risk of contrast-induced acute kidney injury (CI-AKI) remains high. The most important risk factors of CI-AKI in this group of patients remain to be determined as well as their prognostic significance. Aim. The aim of the study was to assess the role of obesity as a risk factor of CI-AKI in patients with stable CAD and AH. Materials and methods. 863 patients with stable CAD and AH were included in the prospective open observational cohort study (ClinicalTrials.gov ID NCT04014153). 398 patients were obese and 465 had body mass index (BMI) below 30 kg/m2. CI-AKI was defined as the 25% rise (or 0.5 mg/dl) of serum creatinine from baseline assessed 48 hours after administration of contrast media. The primary endpoint was the development of CI-AKI. Results. The rate of CI-AKI in patients with obesity was 12.6%, without obesity 12.7%, but the difference between groups was not statistically significant (p=0.935, 95% CI -0.0430.046). The rate of CI-AKI in male patients with obesity was higher than in female ones. The logistic regression model of CI-AKI development in patients with stable CAD, AH and obesity was build (AUC 0.9928, р0,0001, 95% CI 0.98191) and included age, weight, body mass index, female gender, heart failure, diabetes mellitus, proteinuria, anemia, baseline creatinine, contrast volume and the difference between baseline serum creatinine and creatinine level after the contrast media exposure. The baseline level of creatinine and the difference between the levels of creatinine before and after contrast media administration were statistically significant risk factors in the model. Conclusion. The rate of CI-AKI in patients with stable CAD, AH and obesity was 12.6%. The main risk factors of CI-AKI development in multiple logistic regression model were the baseline level of creatinine and the difference between levels of serum creatinine before and after contrast media administration.Olga Iu. MironovaOlga A. SivakovaViktor V. FominIP Morozov P.V.articlecontrast-induced nephropathycontrast-associated acute kidney injurycontrast-induced acute kidney injurycoronary artery diseasepercutaneous coronary interventionarterial hypertensionstable coronary artery diseaseobesityDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 17, Iss 4, Pp 63-67 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
contrast-induced nephropathy contrast-associated acute kidney injury contrast-induced acute kidney injury coronary artery disease percutaneous coronary intervention arterial hypertension stable coronary artery disease obesity Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
contrast-induced nephropathy contrast-associated acute kidney injury contrast-induced acute kidney injury coronary artery disease percutaneous coronary intervention arterial hypertension stable coronary artery disease obesity Diseases of the circulatory (Cardiovascular) system RC666-701 Olga Iu. Mironova Olga A. Sivakova Viktor V. Fomin Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease |
| description |
Background. The prevalence of obesity in patients with stable coronary artery disease (CAD) and arterial hypertension (AH) is increasing each year. As the number of percutaneous coronary interventions requiring contrast media administration is rising in this group of patients, the risk of contrast-induced acute kidney injury (CI-AKI) remains high. The most important risk factors of CI-AKI in this group of patients remain to be determined as well as their prognostic significance.
Aim. The aim of the study was to assess the role of obesity as a risk factor of CI-AKI in patients with stable CAD and AH.
Materials and methods. 863 patients with stable CAD and AH were included in the prospective open observational cohort study (ClinicalTrials.gov ID NCT04014153). 398 patients were obese and 465 had body mass index (BMI) below 30 kg/m2. CI-AKI was defined as the 25% rise (or 0.5 mg/dl) of serum creatinine from baseline assessed 48 hours after administration of contrast media. The primary endpoint was the development of CI-AKI.
Results. The rate of CI-AKI in patients with obesity was 12.6%, without obesity 12.7%, but the difference between groups was not statistically significant (p=0.935, 95% CI -0.0430.046). The rate of CI-AKI in male patients with obesity was higher than in female ones. The logistic regression model of CI-AKI development in patients with stable CAD, AH and obesity was build (AUC 0.9928, р0,0001, 95% CI 0.98191) and included age, weight, body mass index, female gender, heart failure, diabetes mellitus, proteinuria, anemia, baseline creatinine, contrast volume and the difference between baseline serum creatinine and creatinine level after the contrast media exposure. The baseline level of creatinine and the difference between the levels of creatinine before and after contrast media administration were statistically significant risk factors in the model.
Conclusion. The rate of CI-AKI in patients with stable CAD, AH and obesity was 12.6%. The main risk factors of CI-AKI development in multiple logistic regression model were the baseline level of creatinine and the difference between levels of serum creatinine before and after contrast media administration. |
| format |
article |
| author |
Olga Iu. Mironova Olga A. Sivakova Viktor V. Fomin |
| author_facet |
Olga Iu. Mironova Olga A. Sivakova Viktor V. Fomin |
| author_sort |
Olga Iu. Mironova |
| title |
Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease |
| title_short |
Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease |
| title_full |
Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease |
| title_fullStr |
Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease |
| title_full_unstemmed |
Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease |
| title_sort |
obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease |
| publisher |
IP Morozov P.V. |
| publishDate |
2021 |
| url |
https://doaj.org/article/b06e0fed01fa4ef6bbdcbfed80098a72 |
| work_keys_str_mv |
AT olgaiumironova obesityasariskfactorofcontrastinducedacutekidneyinjuryinpatientswitharterialhypertensionandstablecoronaryarterydisease AT olgaasivakova obesityasariskfactorofcontrastinducedacutekidneyinjuryinpatientswitharterialhypertensionandstablecoronaryarterydisease AT viktorvfomin obesityasariskfactorofcontrastinducedacutekidneyinjuryinpatientswitharterialhypertensionandstablecoronaryarterydisease |
| _version_ |
1718406466189131776 |