Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion

Ran, a nucleus-cytoplasm shuttle protein, is implicated in cancer development and survival. Here, the authors show that Ran binds RhoA to impair its degradation and allow its localisation to the plasma membrane of ovarian cancer cells for tumour invasion.

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Autores principales:	Kossay Zaoui, Zied Boudhraa, Paul Khalifé, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0719b6765a344b9be1d3cda2cef7538
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spelling	oai:doaj.org-article:b0719b6765a344b9be1d3cda2cef75382021-12-02T15:35:31ZRan promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion10.1038/s41467-019-10570-w2041-1723https://doaj.org/article/b0719b6765a344b9be1d3cda2cef75382019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10570-whttps://doaj.org/toc/2041-1723Ran, a nucleus-cytoplasm shuttle protein, is implicated in cancer development and survival. Here, the authors show that Ran binds RhoA to impair its degradation and allow its localisation to the plasma membrane of ovarian cancer cells for tumour invasion.Kossay ZaouiZied BoudhraaPaul KhaliféEuridice CarmonaDiane ProvencherAnne-Marie Mes-MassonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kossay Zaoui Zied Boudhraa Paul Khalifé Euridice Carmona Diane Provencher Anne-Marie Mes-Masson Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
description	Ran, a nucleus-cytoplasm shuttle protein, is implicated in cancer development and survival. Here, the authors show that Ran binds RhoA to impair its degradation and allow its localisation to the plasma membrane of ovarian cancer cells for tumour invasion.
format	article
author	Kossay Zaoui Zied Boudhraa Paul Khalifé Euridice Carmona Diane Provencher Anne-Marie Mes-Masson
author_facet	Kossay Zaoui Zied Boudhraa Paul Khalifé Euridice Carmona Diane Provencher Anne-Marie Mes-Masson
author_sort	Kossay Zaoui
title	Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
title_short	Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
title_full	Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
title_fullStr	Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
title_full_unstemmed	Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
title_sort	ran promotes membrane targeting and stabilization of rhoa to orchestrate ovarian cancer cell invasion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b0719b6765a344b9be1d3cda2cef7538
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Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion

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