Current status and perspectives in atomic force microscopy-based identification of cellular transformation

Chenbo Dong, Xiao Hu, Cerasela Zoica Dinu Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV, USA Abstract: Understanding the complex interplay between cells and their biomechanics and how the interplay is influenced by the extracellular microenvironment, a...

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Autores principales:	Dong C, Hu X, Dinu CZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Atomic Force Microscopy (AFM) nanoindentation malignant transformation cancerous phenotype “bio-nano-mechanical signature” Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b0721efc025f4c77900dc0adb3035ffc
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id	oai:doaj.org-article:b0721efc025f4c77900dc0adb3035ffc
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spelling	oai:doaj.org-article:b0721efc025f4c77900dc0adb3035ffc2021-12-02T02:31:35ZCurrent status and perspectives in atomic force microscopy-based identification of cellular transformation1178-2013https://doaj.org/article/b0721efc025f4c77900dc0adb3035ffc2016-05-01T00:00:00Zhttps://www.dovepress.com/current-status-and-perspectives-in-atomic-force-microscopy-based-ident-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chenbo Dong, Xiao Hu, Cerasela Zoica Dinu Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV, USA Abstract: Understanding the complex interplay between cells and their biomechanics and how the interplay is influenced by the extracellular microenvironment, as well as how the transforming potential of a tissue from a benign to a cancerous one is related to the dynamics of both the cell and its surroundings, holds promise for the development of targeted translational therapies. This review provides a comprehensive overview of atomic force microscopy-based technology and its applications for identification of cellular progression to a cancerous phenotype. The review also offers insights into the advancements that are required for the next user-controlled tool to allow for the identification of early cell transformation and thus potentially lead to improved therapeutic outcomes. Keywords: atomic force microscopy (AFM), nanoindentation, malignant transformation, cancerous phenotype, bio-nano-mechanical signatureDong CHu XDinu CZDove Medical PressarticleAtomic Force Microscopy (AFM)nanoindentationmalignant transformationcancerous phenotype“bio-nano-mechanical signature”Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2107-2118 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Atomic Force Microscopy (AFM) nanoindentation malignant transformation cancerous phenotype “bio-nano-mechanical signature” Medicine (General) R5-920
spellingShingle	Atomic Force Microscopy (AFM) nanoindentation malignant transformation cancerous phenotype “bio-nano-mechanical signature” Medicine (General) R5-920 Dong C Hu X Dinu CZ Current status and perspectives in atomic force microscopy-based identification of cellular transformation
description	Chenbo Dong, Xiao Hu, Cerasela Zoica Dinu Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV, USA Abstract: Understanding the complex interplay between cells and their biomechanics and how the interplay is influenced by the extracellular microenvironment, as well as how the transforming potential of a tissue from a benign to a cancerous one is related to the dynamics of both the cell and its surroundings, holds promise for the development of targeted translational therapies. This review provides a comprehensive overview of atomic force microscopy-based technology and its applications for identification of cellular progression to a cancerous phenotype. The review also offers insights into the advancements that are required for the next user-controlled tool to allow for the identification of early cell transformation and thus potentially lead to improved therapeutic outcomes. Keywords: atomic force microscopy (AFM), nanoindentation, malignant transformation, cancerous phenotype, bio-nano-mechanical signature
format	article
author	Dong C Hu X Dinu CZ
author_facet	Dong C Hu X Dinu CZ
author_sort	Dong C
title	Current status and perspectives in atomic force microscopy-based identification of cellular transformation
title_short	Current status and perspectives in atomic force microscopy-based identification of cellular transformation
title_full	Current status and perspectives in atomic force microscopy-based identification of cellular transformation
title_fullStr	Current status and perspectives in atomic force microscopy-based identification of cellular transformation
title_full_unstemmed	Current status and perspectives in atomic force microscopy-based identification of cellular transformation
title_sort	current status and perspectives in atomic force microscopy-based identification of cellular transformation
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b0721efc025f4c77900dc0adb3035ffc
work_keys_str_mv	AT dongc currentstatusandperspectivesinatomicforcemicroscopybasedidentificationofcellulartransformation AT hux currentstatusandperspectivesinatomicforcemicroscopybasedidentificationofcellulartransformation AT dinucz currentstatusandperspectivesinatomicforcemicroscopybasedidentificationofcellulartransformation
_version_	1718402432278462464

Current status and perspectives in atomic force microscopy-based identification of cellular transformation

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