Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness

Abstract Critical care needs have been rising in recent decades as populations age and comorbidities increase. Sepsis-related admissions to critical care contribute up to 50% of volume and septic shock carries a 35–54% fatality rate. Improvements in sepsis-related care and mortality would have a sig...

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Autores principales:	P. Guillaume Poliquin, Mia Biondi, Charlene Ranadheera, Mable Hagan, Alexander Bello, Trina Racine, Mark Allan, Duane Funk, Gregory Hansen, BJ Hancock, Murray Kesselman, Todd Mortimer, Anand Kumar, Shane Jones, Anders Leung, Allen Grolla, Kaylie N. Tran, Kevin Tierney, Xiangguo Qiu, Darwyn Kobasa, James E. Strong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b07496af4298487aa6560c75edfdb595
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spelling	oai:doaj.org-article:b07496af4298487aa6560c75edfdb5952021-12-02T15:05:55ZDelivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness10.1038/s41598-017-01107-62045-2322https://doaj.org/article/b07496af4298487aa6560c75edfdb5952017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01107-6https://doaj.org/toc/2045-2322Abstract Critical care needs have been rising in recent decades as populations age and comorbidities increase. Sepsis-related admissions to critical care contribute up to 50% of volume and septic shock carries a 35–54% fatality rate. Improvements in sepsis-related care and mortality would have a significant impact of a resource-intensive area of health care delivery. Unfortunately, research has been hampered by the lack of an animal model that replicates the complex care provided to humans in an intensive care unit (ICU). We developed a protocol to provide full ICU type supportive care to Rhesus macaques. This included mechanical ventilation, continuous sedation, fluid and electrolyte management and vasopressor support in response to Ebolavirus-induced septic shock. The animals accurately recapitulated human responses to a full range of ICU interventions (e.g. fluid resuscitation). This model can overcome current animal model limitations by accurately emulating the complexity of ICU care and thereby provide a platform for testing new interventions in critical care and sepsis without placing patients at risk.P. Guillaume PoliquinMia BiondiCharlene RanadheeraMable HaganAlexander BelloTrina RacineMark AllanDuane FunkGregory HansenBJ HancockMurray KesselmanTodd MortimerAnand KumarShane JonesAnders LeungAllen GrollaKaylie N. TranKevin TierneyXiangguo QiuDarwyn KobasaJames E. StrongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q P. Guillaume Poliquin Mia Biondi Charlene Ranadheera Mable Hagan Alexander Bello Trina Racine Mark Allan Duane Funk Gregory Hansen BJ Hancock Murray Kesselman Todd Mortimer Anand Kumar Shane Jones Anders Leung Allen Grolla Kaylie N. Tran Kevin Tierney Xiangguo Qiu Darwyn Kobasa James E. Strong Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness
description	Abstract Critical care needs have been rising in recent decades as populations age and comorbidities increase. Sepsis-related admissions to critical care contribute up to 50% of volume and septic shock carries a 35–54% fatality rate. Improvements in sepsis-related care and mortality would have a significant impact of a resource-intensive area of health care delivery. Unfortunately, research has been hampered by the lack of an animal model that replicates the complex care provided to humans in an intensive care unit (ICU). We developed a protocol to provide full ICU type supportive care to Rhesus macaques. This included mechanical ventilation, continuous sedation, fluid and electrolyte management and vasopressor support in response to Ebolavirus-induced septic shock. The animals accurately recapitulated human responses to a full range of ICU interventions (e.g. fluid resuscitation). This model can overcome current animal model limitations by accurately emulating the complexity of ICU care and thereby provide a platform for testing new interventions in critical care and sepsis without placing patients at risk.
format	article
author	P. Guillaume Poliquin Mia Biondi Charlene Ranadheera Mable Hagan Alexander Bello Trina Racine Mark Allan Duane Funk Gregory Hansen BJ Hancock Murray Kesselman Todd Mortimer Anand Kumar Shane Jones Anders Leung Allen Grolla Kaylie N. Tran Kevin Tierney Xiangguo Qiu Darwyn Kobasa James E. Strong
author_facet	P. Guillaume Poliquin Mia Biondi Charlene Ranadheera Mable Hagan Alexander Bello Trina Racine Mark Allan Duane Funk Gregory Hansen BJ Hancock Murray Kesselman Todd Mortimer Anand Kumar Shane Jones Anders Leung Allen Grolla Kaylie N. Tran Kevin Tierney Xiangguo Qiu Darwyn Kobasa James E. Strong
author_sort	P. Guillaume Poliquin
title	Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness
title_short	Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness
title_full	Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness
title_fullStr	Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness
title_full_unstemmed	Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness
title_sort	delivering prolonged intensive care to a non-human primate: a high fidelity animal model of critical illness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b07496af4298487aa6560c75edfdb595
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Delivering Prolonged Intensive Care to a Non-human Primate: A High Fidelity Animal Model of Critical Illness

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