Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases

In modern medical practice, the treatment of cancer is one of the most pressing issues. Many of the drugs used in the treatment of cancer have a toxic effect on the cardiovascular system of patients. The main clinical manifestations of cardiotoxicity are ischemic heart damage, rhythm disturbances, t...

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Autores principales:	Alina A. Aliab'eva, Galina S. Mal
Formato:	article
Lenguaje:	EN RU
Publicado:	Concilium Medicum 2021
Materias:	cardiotoxicity antimetabolites folic acid antagonists pyrimidine antagonists purine antagonists 5-fluorouracil methotrexate cardiac side effects chemotherapy treatment of cancer Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/b077d74e51aa4c57b5967011e83f3f39
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spelling	oai:doaj.org-article:b077d74e51aa4c57b5967011e83f3f392021-12-01T22:07:02ZCardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases2221-71852658-570710.17816/22217185.2021.3.201098https://doaj.org/article/b077d74e51aa4c57b5967011e83f3f392021-10-01T00:00:00Zhttps://cardiosomatics.orscience.ru/2221-7185/article/viewFile/83292/63780https://doaj.org/toc/2221-7185https://doaj.org/toc/2658-5707In modern medical practice, the treatment of cancer is one of the most pressing issues. Many of the drugs used in the treatment of cancer have a toxic effect on the cardiovascular system of patients. The main clinical manifestations of cardiotoxicity are ischemic heart damage, rhythm disturbances, thrombosis, angina, asymptomatic changes in the electrocardiogram, and others. Side effects can develop both during the treatment period and months after the end of the course of chemotherapy. This is especially important for patients with concomitant cardiac or vascular pathology, since the severity of developing side effects can lead to disability or death of cancer survivors. The article discusses the data on the frequency of detection of the negative effect of pyrimidine, purine and folic acid antagonists on the cardiovascular system of cancer patients, the mechanisms of cardiotoxic effects of drugs in such patients, the possibilities of preventing heart damage and correcting for already developed lesions. The aim of this work is to collect, compare and systematize the available disparate data on the cardiotoxic effects of antitumor drugs of the antimetabolite group. An important condition for saving and preserving the quality of life of cancer patients is the identification of cardiovascular pathologies at the stage of preparation for chemotherapy, which can be facilitated by the active cooperation of oncologists and cardiologists. The search for information was carried out on the bases of scientific medical publications (eLibrary.ru, PubMed) taking into account the clinical recommendations for the treatment of malignant neoplasms.Alina A. Aliab'evaGalina S. MalConcilium Medicumarticlecardiotoxicityantimetabolitesfolic acid antagonistspyrimidine antagonistspurine antagonists5-fluorouracilmethotrexatecardiac side effectschemotherapytreatment of cancerDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUКардиоСоматика, Vol 12, Iss 3, Pp 177-181 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	cardiotoxicity antimetabolites folic acid antagonists pyrimidine antagonists purine antagonists 5-fluorouracil methotrexate cardiac side effects chemotherapy treatment of cancer Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	cardiotoxicity antimetabolites folic acid antagonists pyrimidine antagonists purine antagonists 5-fluorouracil methotrexate cardiac side effects chemotherapy treatment of cancer Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Alina A. Aliab'eva Galina S. Mal Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases
description	In modern medical practice, the treatment of cancer is one of the most pressing issues. Many of the drugs used in the treatment of cancer have a toxic effect on the cardiovascular system of patients. The main clinical manifestations of cardiotoxicity are ischemic heart damage, rhythm disturbances, thrombosis, angina, asymptomatic changes in the electrocardiogram, and others. Side effects can develop both during the treatment period and months after the end of the course of chemotherapy. This is especially important for patients with concomitant cardiac or vascular pathology, since the severity of developing side effects can lead to disability or death of cancer survivors. The article discusses the data on the frequency of detection of the negative effect of pyrimidine, purine and folic acid antagonists on the cardiovascular system of cancer patients, the mechanisms of cardiotoxic effects of drugs in such patients, the possibilities of preventing heart damage and correcting for already developed lesions. The aim of this work is to collect, compare and systematize the available disparate data on the cardiotoxic effects of antitumor drugs of the antimetabolite group. An important condition for saving and preserving the quality of life of cancer patients is the identification of cardiovascular pathologies at the stage of preparation for chemotherapy, which can be facilitated by the active cooperation of oncologists and cardiologists. The search for information was carried out on the bases of scientific medical publications (eLibrary.ru, PubMed) taking into account the clinical recommendations for the treatment of malignant neoplasms.
format	article
author	Alina A. Aliab'eva Galina S. Mal
author_facet	Alina A. Aliab'eva Galina S. Mal
author_sort	Alina A. Aliab'eva
title	Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases
title_short	Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases
title_full	Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases
title_fullStr	Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases
title_full_unstemmed	Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases
title_sort	cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases
publisher	Concilium Medicum
publishDate	2021
url	https://doaj.org/article/b077d74e51aa4c57b5967011e83f3f39
work_keys_str_mv	AT alinaaaliabeva cardiotoxiceffectsinducedbytheuseofantimetabolitesinthechemotherapyofoncologicaldiseases AT galinasmal cardiotoxiceffectsinducedbytheuseofantimetabolitesinthechemotherapyofoncologicaldiseases
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Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases

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