Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)

Abstract Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised...

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Autores principales:	Sophie Reale, Rebecca R. Turner, Eileen Sutton, Liz Steed, Stephanie J. C. Taylor, Dylan Morrissey, Patrick Doherty, Diana M. Greenfield, Michelle Collinson, Jenny Hewison, Janet Brown, Saïd Ibeggazene, Malcolm Mason, Derek J. Rosario, Liam Bourke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b077e1661d32477b80e51a1f709599ec
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spelling	oai:doaj.org-article:b077e1661d32477b80e51a1f709599ec2021-12-02T16:04:18ZEmbedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)10.1038/s41598-021-91876-y2045-2322https://doaj.org/article/b077e1661d32477b80e51a1f709599ec2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91876-yhttps://doaj.org/toc/2045-2322Abstract Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training intervention into standard prostate cancer care in a single-arm, multicentre prospective cohort study. Feasibility included recruitment, retention, adherence, fidelity and safety. Acceptability of behaviourally informed healthcare and exercise professional training was assessed qualitatively. Despite the imposition of lockdown for the COVID-19 pandemic, referral rates into and adherence to, the intervention was high. Of the 45 men eligible for participation, 79% (n = 36) received the intervention and 47% (n = 21) completed the intervention before a government mandated national lockdown was enforced in the United Kingdom. Patients completed a mean of 27 min of aerobic exercise per session (SD = 3.48), at 77% heart rate maximum (92% of target dose), and 3 sets of 10 reps of 3 resistance exercises twice weekly for 12 weeks, without serious adverse event. The intervention was delivered by 26 healthcare professionals and 16 exercise trainers with moderate to high fidelity, and the intervention was deemed highly acceptable to patients. The impact of societal changes due to the pandemic on the delivery of this face-to-face intervention remain uncertain but positive impacts of embedding exercise provision into prostate cancer care warrant long-term investigation.Sophie RealeRebecca R. TurnerEileen SuttonLiz SteedStephanie J. C. TaylorDylan MorrisseyPatrick DohertyDiana M. GreenfieldMichelle CollinsonJenny HewisonJanet BrownSaïd IbeggazeneMalcolm MasonDerek J. RosarioLiam BourkeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sophie Reale Rebecca R. Turner Eileen Sutton Liz Steed Stephanie J. C. Taylor Dylan Morrissey Patrick Doherty Diana M. Greenfield Michelle Collinson Jenny Hewison Janet Brown Saïd Ibeggazene Malcolm Mason Derek J. Rosario Liam Bourke Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)
description	Abstract Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training intervention into standard prostate cancer care in a single-arm, multicentre prospective cohort study. Feasibility included recruitment, retention, adherence, fidelity and safety. Acceptability of behaviourally informed healthcare and exercise professional training was assessed qualitatively. Despite the imposition of lockdown for the COVID-19 pandemic, referral rates into and adherence to, the intervention was high. Of the 45 men eligible for participation, 79% (n = 36) received the intervention and 47% (n = 21) completed the intervention before a government mandated national lockdown was enforced in the United Kingdom. Patients completed a mean of 27 min of aerobic exercise per session (SD = 3.48), at 77% heart rate maximum (92% of target dose), and 3 sets of 10 reps of 3 resistance exercises twice weekly for 12 weeks, without serious adverse event. The intervention was delivered by 26 healthcare professionals and 16 exercise trainers with moderate to high fidelity, and the intervention was deemed highly acceptable to patients. The impact of societal changes due to the pandemic on the delivery of this face-to-face intervention remain uncertain but positive impacts of embedding exercise provision into prostate cancer care warrant long-term investigation.
format	article
author	Sophie Reale Rebecca R. Turner Eileen Sutton Liz Steed Stephanie J. C. Taylor Dylan Morrissey Patrick Doherty Diana M. Greenfield Michelle Collinson Jenny Hewison Janet Brown Saïd Ibeggazene Malcolm Mason Derek J. Rosario Liam Bourke
author_facet	Sophie Reale Rebecca R. Turner Eileen Sutton Liz Steed Stephanie J. C. Taylor Dylan Morrissey Patrick Doherty Diana M. Greenfield Michelle Collinson Jenny Hewison Janet Brown Saïd Ibeggazene Malcolm Mason Derek J. Rosario Liam Bourke
author_sort	Sophie Reale
title	Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)
title_short	Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)
title_full	Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)
title_fullStr	Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)
title_full_unstemmed	Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)
title_sort	embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the stamina trial)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b077e1661d32477b80e51a1f709599ec
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Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)

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