Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management

Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving...

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Autores principales:	Hanna Zając, Anna Turno-Kręcicka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Behçet’s disease ocular Behçet uveitis management of Behçet’s disease Medicine R
Acceso en línea:	https://doaj.org/article/b0798c040b5b45b29cafcb5f28bb8518
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spelling	oai:doaj.org-article:b0798c040b5b45b29cafcb5f28bb85182021-11-11T17:47:11ZOcular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management10.3390/jcm102151742077-0383https://doaj.org/article/b0798c040b5b45b29cafcb5f28bb85182021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5174https://doaj.org/toc/2077-0383Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving due to the clinical phenotypes recently described in the literature and increasing focus on the detection of subclinical inflammation to enable correct therapeutic decisions. The first line treatment is azathioprine, followed by various immunosuppressive and biological agents as alternatives in severe or refractory cases. This review summarizes scientific articles about the etiology of, diagnostic tools for and treatment of the ocular manifestations of Behçet’s disease available in the PubMed database from 1 January 2016 to 1 May 2021. A multidisciplinary approach is necessary to effectively prevent permanent damage and thus improve the life quality of the patients. Therefore, it is crucial to raise awareness of the common clusters of symptoms, use of modern imaging methods, such as ocular computed tomography and fluorescein angiography, and novelty treatment algorithms to enable early diagnosis and appropriate management.Hanna ZającAnna Turno-KręcickaMDPI AGarticleBehçet’s diseaseocular Behçetuveitismanagement of Behçet’s diseaseMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5174, p 5174 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Behçet’s disease ocular Behçet uveitis management of Behçet’s disease Medicine R
spellingShingle	Behçet’s disease ocular Behçet uveitis management of Behçet’s disease Medicine R Hanna Zając Anna Turno-Kręcicka Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
description	Behçet’s disease is a systemic vasculitis that affects multiple organs. The most common manifestations are oral and genital ulcerations and recurrent uveitis. Uveitis can be an initial symptom in 10–20% of cases and leads to blindness in 16–25% of patients. The management of this disease is evolving due to the clinical phenotypes recently described in the literature and increasing focus on the detection of subclinical inflammation to enable correct therapeutic decisions. The first line treatment is azathioprine, followed by various immunosuppressive and biological agents as alternatives in severe or refractory cases. This review summarizes scientific articles about the etiology of, diagnostic tools for and treatment of the ocular manifestations of Behçet’s disease available in the PubMed database from 1 January 2016 to 1 May 2021. A multidisciplinary approach is necessary to effectively prevent permanent damage and thus improve the life quality of the patients. Therefore, it is crucial to raise awareness of the common clusters of symptoms, use of modern imaging methods, such as ocular computed tomography and fluorescein angiography, and novelty treatment algorithms to enable early diagnosis and appropriate management.
format	article
author	Hanna Zając Anna Turno-Kręcicka
author_facet	Hanna Zając Anna Turno-Kręcicka
author_sort	Hanna Zając
title	Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_short	Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_full	Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_fullStr	Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_full_unstemmed	Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management
title_sort	ocular manifestations of behçet’s disease: an update on diagnostic challenges and disease management
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b0798c040b5b45b29cafcb5f28bb8518
work_keys_str_mv	AT hannazajac ocularmanifestationsofbehcetsdiseaseanupdateondiagnosticchallengesanddiseasemanagement AT annaturnokrecicka ocularmanifestationsofbehcetsdiseaseanupdateondiagnosticchallengesanddiseasemanagement
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Ocular Manifestations of Behçet’s Disease: An Update on Diagnostic Challenges and Disease Management

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